ID:CAN8_HUMAN DESCRIPTION: RecName: Full=Calpain-8; EC=3.4.22.53; AltName: Full=New calpain 2; Short=nCL-2; AltName: Full=Stomach-specific M-type calpain; FUNCTION: Calcium-regulated non-lysosomal thiol-protease. Involved in membrane trafficking in the gastric surface mucus cells (pit cells) and may involve the membrane trafficking of mucus cells via interactions with coat protein. Proteolytically cleaves the beta- subunit of coatomer complex (By similarity). CATALYTIC ACTIVITY: Broad endopeptidase specificity. COFACTOR: Binds 2 calcium ions (Potential). SUBUNIT: Monomer and homooligomer. Interacts with COPS1/GPS1, COPB1, EYA2, NME2, NME4 and TOMM70A (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). Golgi apparatus (By similarity). TISSUE SPECIFICITY: Stomach. DOMAIN: The domain III mediates oligomerization (By similarity). PTM: Undergoes autolytic cleavage between Ala-5 and Ala-6 which gives rise to fragments extending from Ala-6 to the C-terminus, Ala-6 to the EF-hand 2 domain and from Ala-6 to the beginning of domain III (By similarity). SIMILARITY: Belongs to the peptidase C2 family. SIMILARITY: Contains 1 calpain catalytic domain. SIMILARITY: Contains 3 EF-hand domains.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on A6NHC0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
