Human Gene CAMSAP3 (ENST00000160298.9_10) from GENCODE V47lift37
  Description: calmodulin regulated spectrin associated protein family member 3, transcript variant 2 (from RefSeq NM_020902.2)
Gencode Transcript: ENST00000160298.9_10
Gencode Gene: ENSG00000076826.10_12
Transcript (Including UTRs)
   Position: hg19 chr19:7,660,749-7,683,190 Size: 22,442 Total Exon Count: 17 Strand: +
Coding Region
   Position: hg19 chr19:7,660,889-7,682,943 Size: 22,055 Coding Exon Count: 17 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:7,660,749-7,683,190)mRNA (may differ from genome)Protein (1249 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MGIOMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CAMP3_HUMAN
DESCRIPTION: RecName: Full=Calmodulin-regulated spectrin-associated protein 3; AltName: Full=Protein Nezha;
FUNCTION: Microtubule minus-end binding protein that acts as a regulator of microtubule dynamics. Specifically required for zonula adherens biogenesis and maintenance by anchoring microtubules at their minus-ends to zonula adherens, leading to recruit KIFC3 kinesin to junctional site.
SUBUNIT: Interacts with PLEKHA7.
SUBCELLULAR LOCATION: Cell junction, adherens junction. Cytoplasm. Cytoplasm, cytoskeleton (Potential). Note=Scattered in the cytoplasm. Localizes along zonula adherens only at mature cell- cell contacts.
DOMAIN: The CKK domain binds microtubules (By similarity).
MISCELLANEOUS: 'Nezha' is a deity in Chinese mythology.
SIMILARITY: Belongs to the CAMSAP1 family.
SIMILARITY: Contains 1 CH (calponin-homology) domain.
SIMILARITY: Contains 1 CKK domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 47.12 RPKM in Skin - Not Sun Exposed (Suprapubic)
Total median expression: 380.57 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -88.50140-0.632 Picture PostScript Text
3' UTR -104.90247-0.425 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001715 - CH-domain
IPR014797 - CKK_domain
IPR011033 - PRC_barrell-like

Pfam Domains:
PF08683 - Microtubule-binding calmodulin-regulated spectrin-associated
PF11971 - CAMSAP CH domain
PF17095 - Spectrin-binding region of Ca2+-Calmodulin

SCOP Domains:
47576 - Calponin-homology domain, CH-domain
50346 - PRC-barrel domain

ModBase Predicted Comparative 3D Structure on Q9P1Y5
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0008017 microtubule binding
GO:0030507 spectrin binding
GO:0051011 microtubule minus-end binding
GO:0051015 actin filament binding

Biological Process:
GO:0000226 microtubule cytoskeleton organization
GO:0009792 embryo development ending in birth or egg hatching
GO:0010923 negative regulation of phosphatase activity
GO:0030334 regulation of cell migration
GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity
GO:0031113 regulation of microtubule polymerization
GO:0031175 neuron projection development
GO:0033043 regulation of organelle organization
GO:0034453 microtubule anchoring
GO:0045198 establishment of epithelial cell apical/basal polarity
GO:0045218 zonula adherens maintenance
GO:0051893 regulation of focal adhesion assembly
GO:0070507 regulation of microtubule cytoskeleton organization
GO:0090136 epithelial cell-cell adhesion
GO:0098840 protein transport along microtubule
GO:1903358 regulation of Golgi organization

Cellular Component:
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0005912 adherens junction
GO:0005915 zonula adherens
GO:0030054 cell junction
GO:0036449 microtubule minus-end
GO:0005813 centrosome


-  Descriptions from all associated GenBank mRNAs
  LF208006 - JP 2014500723-A/15509: Polycomb-Associated Non-Coding RNAs.
JD186849 - Sequence 167873 from Patent EP1572962.
JC506674 - Sequence 42 from Patent EP2733220.
JC737786 - Sequence 42 from Patent WO2014075939.
JC506688 - Sequence 56 from Patent EP2733220.
JC737800 - Sequence 56 from Patent WO2014075939.
BC035808 - Homo sapiens KIAA1543, mRNA (cDNA clone IMAGE:5745021), with apparent retained intron.
LF370932 - JP 2014500723-A/178435: Polycomb-Associated Non-Coding RNAs.
JD460762 - Sequence 441786 from Patent EP1572962.
BC020431 - Homo sapiens KIAA1543, mRNA (cDNA clone IMAGE:3868695).
LF370933 - JP 2014500723-A/178436: Polycomb-Associated Non-Coding RNAs.
LF370940 - JP 2014500723-A/178443: Polycomb-Associated Non-Coding RNAs.
LF370941 - JP 2014500723-A/178444: Polycomb-Associated Non-Coding RNAs.
LF370942 - JP 2014500723-A/178445: Polycomb-Associated Non-Coding RNAs.
AB040976 - Homo sapiens mRNA for KIAA1543 protein, partial cds.
JD527306 - Sequence 508330 from Patent EP1572962.
AL833927 - Homo sapiens mRNA; cDNA DKFZp434H0412 (from clone DKFZp434H0412).
AF289580 - Homo sapiens clone pp7106 unknown mRNA.
LF370944 - JP 2014500723-A/178447: Polycomb-Associated Non-Coding RNAs.
LF370945 - JP 2014500723-A/178448: Polycomb-Associated Non-Coding RNAs.
BC064490 - Homo sapiens KIAA1543, mRNA (cDNA clone IMAGE:4578704), partial cds.
BC036935 - Homo sapiens KIAA1543, mRNA (cDNA clone IMAGE:5242408), with apparent retained intron.
LF370947 - JP 2014500723-A/178450: Polycomb-Associated Non-Coding RNAs.
LF370951 - JP 2014500723-A/178454: Polycomb-Associated Non-Coding RNAs.
BC128201 - Homo sapiens KIAA1543, mRNA (cDNA clone IMAGE:40114009), partial cds.
BC128202 - Homo sapiens KIAA1543, mRNA (cDNA clone IMAGE:40114010), partial cds.
LF208008 - JP 2014500723-A/15511: Polycomb-Associated Non-Coding RNAs.
LF370953 - JP 2014500723-A/178456: Polycomb-Associated Non-Coding RNAs.
JD486818 - Sequence 467842 from Patent EP1572962.
JD494141 - Sequence 475165 from Patent EP1572962.
JD167316 - Sequence 148340 from Patent EP1572962.
JD147708 - Sequence 128732 from Patent EP1572962.
JD217975 - Sequence 198999 from Patent EP1572962.
MA606509 - JP 2018138019-A/178435: Polycomb-Associated Non-Coding RNAs.
MA606510 - JP 2018138019-A/178436: Polycomb-Associated Non-Coding RNAs.
MA606517 - JP 2018138019-A/178443: Polycomb-Associated Non-Coding RNAs.
MA606518 - JP 2018138019-A/178444: Polycomb-Associated Non-Coding RNAs.
MA606519 - JP 2018138019-A/178445: Polycomb-Associated Non-Coding RNAs.
MA606521 - JP 2018138019-A/178447: Polycomb-Associated Non-Coding RNAs.
MA606522 - JP 2018138019-A/178448: Polycomb-Associated Non-Coding RNAs.
MA606524 - JP 2018138019-A/178450: Polycomb-Associated Non-Coding RNAs.
MA606528 - JP 2018138019-A/178454: Polycomb-Associated Non-Coding RNAs.
MA606530 - JP 2018138019-A/178456: Polycomb-Associated Non-Coding RNAs.
MA443583 - JP 2018138019-A/15509: Polycomb-Associated Non-Coding RNAs.
MA443585 - JP 2018138019-A/15511: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: CAMP3_HUMAN, CAMSAP3 , ENST00000160298.1, ENST00000160298.2, ENST00000160298.3, ENST00000160298.4, ENST00000160298.5, ENST00000160298.6, ENST00000160298.7, ENST00000160298.8, KIAA1543 , NM_020902, Q8NDF1, Q9P1Y5, uc317cch.1, uc317cch.2
UCSC ID: ENST00000160298.9_10
RefSeq Accession: NM_020902.2
Protein: Q9P1Y5 (aka CAMP3_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.