ID:CAMP3_HUMAN DESCRIPTION: RecName: Full=Calmodulin-regulated spectrin-associated protein 3; AltName: Full=Protein Nezha; FUNCTION: Microtubule minus-end binding protein that acts as a regulator of microtubule dynamics. Specifically required for zonula adherens biogenesis and maintenance by anchoring microtubules at their minus-ends to zonula adherens, leading to recruit KIFC3 kinesin to junctional site. SUBUNIT: Interacts with PLEKHA7. SUBCELLULAR LOCATION: Cell junction, adherens junction. Cytoplasm. Cytoplasm, cytoskeleton (Potential). Note=Scattered in the cytoplasm. Localizes along zonula adherens only at mature cell- cell contacts. DOMAIN: The CKK domain binds microtubules (By similarity). MISCELLANEOUS: 'Nezha' is a deity in Chinese mythology. SIMILARITY: Belongs to the CAMSAP1 family. SIMILARITY: Contains 1 CH (calponin-homology) domain. SIMILARITY: Contains 1 CKK domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9P1Y5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.