Human Gene CAMSAP1 (ENST00000389532.9_9) from GENCODE V47lift37
  Description: calmodulin regulated spectrin associated protein 1 (from RefSeq NM_015447.4)
Gencode Transcript: ENST00000389532.9_9
Gencode Gene: ENSG00000130559.19_12
Transcript (Including UTRs)
   Position: hg19 chr9:138,700,333-138,799,392 Size: 99,060 Total Exon Count: 17 Strand: -
Coding Region
   Position: hg19 chr9:138,703,155-138,799,005 Size: 95,851 Coding Exon Count: 17 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr9:138,700,333-138,799,392)mRNA (may differ from genome)Protein (1602 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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HGNCMGIOMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CAMP1_HUMAN
DESCRIPTION: RecName: Full=Calmodulin-regulated spectrin-associated protein 1;
FUNCTION: Plays a role in the regulation of cell morphology and cytoskeletal organization.
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton (Potential).
DOMAIN: The CKK domain binds microtubules.
SIMILARITY: Belongs to the CAMSAP1 family.
SIMILARITY: Contains 1 CH (calponin-homology) domain.
SIMILARITY: Contains 1 CKK domain.
SEQUENCE CAUTION: Sequence=AAI30581.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 18.68 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 327.87 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -235.80387-0.609 Picture PostScript Text
3' UTR -842.702822-0.299 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR022613 - CAMSAP_CH
IPR001715 - CH-domain
IPR014797 - CKK_domain
IPR011033 - PRC_barrell-like

Pfam Domains:
PF08683 - Microtubule-binding calmodulin-regulated spectrin-associated
PF11971 - CAMSAP CH domain
PF17095 - Spectrin-binding region of Ca2+-Calmodulin

SCOP Domains:
47576 - Calponin-homology domain, CH-domain
50346 - PRC-barrel domain

ModBase Predicted Comparative 3D Structure on Q5T5Y3
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserNo ortholog
Gene DetailsGene Details  Gene Details 
Gene SorterGene Sorter  Gene Sorter 
 RGD  WormBase 
    Protein Sequence 
    Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005516 calmodulin binding
GO:0008017 microtubule binding
GO:0030507 spectrin binding
GO:0051011 microtubule minus-end binding

Biological Process:
GO:0000226 microtubule cytoskeleton organization
GO:0007010 cytoskeleton organization
GO:0022604 regulation of cell morphogenesis
GO:0031113 regulation of microtubule polymerization
GO:0031175 neuron projection development

Cellular Component:
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0036449 microtubule minus-end


-  Descriptions from all associated GenBank mRNAs
  AK025533 - Homo sapiens cDNA: FLJ21880 fis, clone HEP02743.
AL834528 - Homo sapiens mRNA; cDNA DKFZp434G2311 (from clone DKFZp434G2311).
LF383682 - JP 2014500723-A/191185: Polycomb-Associated Non-Coding RNAs.
AK055790 - Homo sapiens cDNA FLJ31228 fis, clone KIDNE2004475.
BC010646 - Homo sapiens calmodulin regulated spectrin-associated protein 1, mRNA (cDNA clone IMAGE:3865907), partial cds.
BC012778 - Homo sapiens calmodulin regulated spectrin-associated protein 1, mRNA (cDNA clone IMAGE:3939659), partial cds.
AJ519841 - Homo sapiens mRNA for calmodulin regulated spectrin-associated protein 1 (CAMSAP1 gene).
AJ420438 - Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 1580818.
JD079878 - Sequence 60902 from Patent EP1572962.
BC040549 - Homo sapiens calmodulin regulated spectrin-associated protein 1, mRNA (cDNA clone IMAGE:5295469), with apparent retained intron.
BC130580 - Homo sapiens calmodulin regulated spectrin-associated protein 1, mRNA (cDNA clone MGC:163452 IMAGE:40146611), complete cds.
BC144082 - Homo sapiens calmodulin regulated spectrin-associated protein 1, mRNA (cDNA clone MGC:177619 IMAGE:9052602), complete cds.
JD162019 - Sequence 143043 from Patent EP1572962.
LF346368 - JP 2014500723-A/153871: Polycomb-Associated Non-Coding RNAs.
JD249245 - Sequence 230269 from Patent EP1572962.
JD292243 - Sequence 273267 from Patent EP1572962.
JD137535 - Sequence 118559 from Patent EP1572962.
JD551244 - Sequence 532268 from Patent EP1572962.
GQ891365 - Homo sapiens clone HEL-S-153l epididymis secretory sperm binding protein mRNA, complete cds.
LF346372 - JP 2014500723-A/153875: Polycomb-Associated Non-Coding RNAs.
LF346373 - JP 2014500723-A/153876: Polycomb-Associated Non-Coding RNAs.
AL117634 - Homo sapiens mRNA; cDNA DKFZp434F195 (from clone DKFZp434F195).
LF346374 - JP 2014500723-A/153877: Polycomb-Associated Non-Coding RNAs.
JD522648 - Sequence 503672 from Patent EP1572962.
JD097964 - Sequence 78988 from Patent EP1572962.
JD346927 - Sequence 327951 from Patent EP1572962.
LF346375 - JP 2014500723-A/153878: Polycomb-Associated Non-Coding RNAs.
JD553580 - Sequence 534604 from Patent EP1572962.
LF346376 - JP 2014500723-A/153879: Polycomb-Associated Non-Coding RNAs.
AF116701 - Homo sapiens PRO2405 mRNA, complete cds.
JD272624 - Sequence 253648 from Patent EP1572962.
JD458466 - Sequence 439490 from Patent EP1572962.
JD467129 - Sequence 448153 from Patent EP1572962.
MA619259 - JP 2018138019-A/191185: Polycomb-Associated Non-Coding RNAs.
MA581945 - JP 2018138019-A/153871: Polycomb-Associated Non-Coding RNAs.
MA581949 - JP 2018138019-A/153875: Polycomb-Associated Non-Coding RNAs.
MA581950 - JP 2018138019-A/153876: Polycomb-Associated Non-Coding RNAs.
MA581951 - JP 2018138019-A/153877: Polycomb-Associated Non-Coding RNAs.
MA581952 - JP 2018138019-A/153878: Polycomb-Associated Non-Coding RNAs.
MA581953 - JP 2018138019-A/153879: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: A1L4L2, B2REB2, B2REB3, CAMP1_HUMAN, ENST00000389532.1, ENST00000389532.2, ENST00000389532.3, ENST00000389532.4, ENST00000389532.5, ENST00000389532.6, ENST00000389532.7, ENST00000389532.8, NM_015447, Q5T5Y3, Q70W33, Q8NCY0, Q96E80, Q96FM3, Q9UFJ5, uc318tfp.1, uc318tfp.2
UCSC ID: ENST00000389532.9_9
RefSeq Accession: NM_015447.4
Protein: Q5T5Y3 (aka CAMP1_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.