Human Gene CAMK2A (ENST00000671881.1_13) from GENCODE V47lift37
  Description: calcium/calmodulin dependent protein kinase II alpha, transcript variant 1 (from RefSeq NM_015981.4)
Gencode Transcript: ENST00000671881.1_13
Gencode Gene: ENSG00000070808.17_18
Transcript (Including UTRs)
   Position: hg19 chr5:149,599,054-149,669,336 Size: 70,283 Total Exon Count: 19 Strand: -
Coding Region
   Position: hg19 chr5:149,602,273-149,669,188 Size: 66,916 Coding Exon Count: 19 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr5:149,599,054-149,669,336)mRNA (may differ from genome)Protein (489 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: KCC2A_HUMAN
DESCRIPTION: RecName: Full=Calcium/calmodulin-dependent protein kinase type II subunit alpha; Short=CaM kinase II subunit alpha; Short=CaMK-II subunit alpha; EC=2.7.11.17;
FUNCTION: CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity).
CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
ENZYME REGULATION: Autophosphorylation of Thr-286 allows the kinase to switch from a calmodulin-dependent to a calmodulin- independent state (By similarity).
SUBUNIT: CAMK2 is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. Interacts with BAALC, MPDZ, SYN1, CAMK2N2 and SYNGAP1 (By similarity).
SUBCELLULAR LOCATION: Cell junction, synapse, presynaptic cell membrane (By similarity). Cell junction, synapse (By similarity). Note=Postsynaptic lipid rafts (By similarity).
SIMILARITY: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
SIMILARITY: Contains 1 protein kinase domain.
SEQUENCE CAUTION: Sequence=BAA76812.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: CAMK2A
Diseases sorted by gene-association score: conduct disorder (7)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • D003024 Clozapine
  • D003042 Cocaine
  • D000431 Ethanol
  • C006253 pirinixic acid
  • C070379 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester
  • C060229 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione
  • C109986 2-aminoethoxydiphenyl borate
  • C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid
  • C057013 7-chlorokynurenic acid
  • D000082 Acetaminophen
          more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -54.30148-0.367 Picture PostScript Text
3' UTR -1221.603219-0.379 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR020636 - Ca/CaM-dep_Ca-dep_prot_Kinase
IPR013543 - Ca/CaM-dep_prot_kinase-assoc
IPR011009 - Kinase-like_dom
IPR000719 - Prot_kinase_cat_dom
IPR017441 - Protein_kinase_ATP_BS
IPR002290 - Ser/Thr_dual-sp_kinase_dom
IPR008271 - Ser/Thr_kinase_AS

Pfam Domains:
PF00069 - Protein kinase domain
PF07714 - Protein tyrosine and serine/threonine kinase
PF08332 - Calcium/calmodulin dependent protein kinase II association domain
PF13474 - SnoaL-like domain
PF14534 - Domain of unknown function (DUF4440)

SCOP Domains:
56112 - Protein kinase-like (PK-like)
54427 - NTF2-like

Protein Data Bank (PDB) 3-D Structure
MuPIT help
2VZ6 - X-ray MuPIT 3SOA - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on Q9UQM7
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004683 calmodulin-dependent protein kinase activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0009931 calcium-dependent protein serine/threonine kinase activity
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0035254 glutamate receptor binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding

Biological Process:
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000165 MAPK cascade
GO:0002931 response to ischemia
GO:0006468 protein phosphorylation
GO:0006816 calcium ion transport
GO:0007223 Wnt signaling pathway, calcium modulating pathway
GO:0007399 nervous system development
GO:0010666 positive regulation of cardiac muscle cell apoptotic process
GO:0016310 phosphorylation
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0030154 cell differentiation
GO:0035556 intracellular signal transduction
GO:0038166 angiotensin-activated signaling pathway
GO:0046777 protein autophosphorylation
GO:0046928 regulation of neurotransmitter secretion
GO:0048168 regulation of neuronal synaptic plasticity
GO:0048813 dendrite morphogenesis
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051928 positive regulation of calcium ion transport
GO:0060333 interferon-gamma-mediated signaling pathway
GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0030054 cell junction
GO:0030666 endocytic vesicle membrane
GO:0042734 presynaptic membrane
GO:0043005 neuron projection
GO:0045202 synapse


-  Descriptions from all associated GenBank mRNAs
  AF145710 - Homo sapiens calcium/calmodulin-dependent protein kinase II alpha subunit mRNA, complete cds.
AF145711 - Homo sapiens calcium/calmodulin-dependent protein kinase II alpha-B subunit mRNA, complete cds.
BC040457 - Homo sapiens calcium/calmodulin-dependent protein kinase II alpha, mRNA (cDNA clone MGC:26106 IMAGE:4811948), complete cds.
JA482049 - Sequence 32 from Patent WO2011072091.
JA482050 - Sequence 33 from Patent WO2011072091.
JE980341 - Sequence 32 from Patent EP2862929.
JE980342 - Sequence 33 from Patent EP2862929.
AB023185 - Homo sapiens KIAA0968 mRNA for KIAA0968 protein.
JD217832 - Sequence 198856 from Patent EP1572962.
JD042058 - Sequence 23082 from Patent EP1572962.
JD264287 - Sequence 245311 from Patent EP1572962.
JD527904 - Sequence 508928 from Patent EP1572962.
JD512926 - Sequence 493950 from Patent EP1572962.
JD183117 - Sequence 164141 from Patent EP1572962.
JD251118 - Sequence 232142 from Patent EP1572962.
JD327089 - Sequence 308113 from Patent EP1572962.
JD357939 - Sequence 338963 from Patent EP1572962.
JD565771 - Sequence 546795 from Patent EP1572962.
JD496553 - Sequence 477577 from Patent EP1572962.
JD235290 - Sequence 216314 from Patent EP1572962.
JD542479 - Sequence 523503 from Patent EP1572962.
JD263016 - Sequence 244040 from Patent EP1572962.
JD348222 - Sequence 329246 from Patent EP1572962.
JD455803 - Sequence 436827 from Patent EP1572962.
JD493875 - Sequence 474899 from Patent EP1572962.
JD270486 - Sequence 251510 from Patent EP1572962.
JD524361 - Sequence 505385 from Patent EP1572962.
JD501068 - Sequence 482092 from Patent EP1572962.
JD047155 - Sequence 28179 from Patent EP1572962.
JD123125 - Sequence 104149 from Patent EP1572962.
JD290614 - Sequence 271638 from Patent EP1572962.
JD138484 - Sequence 119508 from Patent EP1572962.
JD127753 - Sequence 108777 from Patent EP1572962.
JD488767 - Sequence 469791 from Patent EP1572962.
JD478909 - Sequence 459933 from Patent EP1572962.
JD550454 - Sequence 531478 from Patent EP1572962.
JD090938 - Sequence 71962 from Patent EP1572962.
JD039757 - Sequence 20781 from Patent EP1572962.
JD166516 - Sequence 147540 from Patent EP1572962.
JD116762 - Sequence 97786 from Patent EP1572962.
JD133538 - Sequence 114562 from Patent EP1572962.
JD220992 - Sequence 202016 from Patent EP1572962.
JD241066 - Sequence 222090 from Patent EP1572962.
JD298171 - Sequence 279195 from Patent EP1572962.
JD193300 - Sequence 174324 from Patent EP1572962.
JD288650 - Sequence 269674 from Patent EP1572962.
JD261506 - Sequence 242530 from Patent EP1572962.
JD343577 - Sequence 324601 from Patent EP1572962.
JD079214 - Sequence 60238 from Patent EP1572962.
JD168749 - Sequence 149773 from Patent EP1572962.
JD369502 - Sequence 350526 from Patent EP1572962.
JD433406 - Sequence 414430 from Patent EP1572962.
JD409787 - Sequence 390811 from Patent EP1572962.
JD220690 - Sequence 201714 from Patent EP1572962.
JD515601 - Sequence 496625 from Patent EP1572962.
JD191394 - Sequence 172418 from Patent EP1572962.
JD402341 - Sequence 383365 from Patent EP1572962.
JD231772 - Sequence 212796 from Patent EP1572962.
JD164003 - Sequence 145027 from Patent EP1572962.
JD130147 - Sequence 111171 from Patent EP1572962.
JD470677 - Sequence 451701 from Patent EP1572962.
JD064915 - Sequence 45939 from Patent EP1572962.
JD340611 - Sequence 321635 from Patent EP1572962.
AK289776 - Homo sapiens cDNA FLJ75193 complete cds, highly similar to Homo sapiens calcium/calmodulin-dependent protein kinase II alpha-B subunit mRNA.
JD161345 - Sequence 142369 from Patent EP1572962.
JD132661 - Sequence 113685 from Patent EP1572962.
JD067906 - Sequence 48930 from Patent EP1572962.
JD163933 - Sequence 144957 from Patent EP1572962.
JD524446 - Sequence 505470 from Patent EP1572962.
JD132550 - Sequence 113574 from Patent EP1572962.
LF383490 - JP 2014500723-A/190993: Polycomb-Associated Non-Coding RNAs.
LF211062 - JP 2014500723-A/18565: Polycomb-Associated Non-Coding RNAs.
JD350741 - Sequence 331765 from Patent EP1572962.
JD134827 - Sequence 115851 from Patent EP1572962.
JD160325 - Sequence 141349 from Patent EP1572962.
LF343661 - JP 2014500723-A/151164: Polycomb-Associated Non-Coding RNAs.
JD172297 - Sequence 153321 from Patent EP1572962.
JD427378 - Sequence 408402 from Patent EP1572962.
JD206301 - Sequence 187325 from Patent EP1572962.
JD516623 - Sequence 497647 from Patent EP1572962.
JD215046 - Sequence 196070 from Patent EP1572962.
AF091486 - Homo sapiens calmodulin-dependent protein kinase II alpha mRNA, complete cds.
AB385410 - Synthetic construct DNA, clone: pF1KA0968, Homo sapiens CAMK2A gene for calcium/calmodulin-dependent protein kinase type II alpha chain, complete cds, without stop codon, in Flexi system.
EU832105 - Synthetic construct Homo sapiens clone HAIB:100067134; DKFZo008B0725 calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha protein (CAMK2A) gene, encodes complete protein.
EU832199 - Synthetic construct Homo sapiens clone HAIB:100067228; DKFZo004B0726 calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha protein (CAMK2A) gene, encodes complete protein.
AK308853 - Homo sapiens cDNA, FLJ98894.
AY429524 - Homo sapiens CAMK2Av_1 mRNA sequence; alternatively spliced.
MA619067 - JP 2018138019-A/190993: Polycomb-Associated Non-Coding RNAs.
MA579238 - JP 2018138019-A/151164: Polycomb-Associated Non-Coding RNAs.
MA446639 - JP 2018138019-A/18565: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9UQM7 (Reactome details) participates in the following event(s):

R-HSA-4332359 Active calmodulin binds CAMK2
R-HSA-4332356 CAMK2 binds MAP3K7
R-HSA-4332358 Dissociation of CaM and CAMK2 autophosphorylation
R-HSA-442725 Activation of CaMKII
R-HSA-445367 CaMKII enters cytoplasm
R-HSA-444792 CaMKII enters nucleus
R-HSA-4332363 Autophosphorylation and activation of CAMK2
R-HSA-416320 Trafficking of GluR1-containing AMPA receptors
R-HSA-5082387 Phosphorylation of HSF1 at Ser230 induces transactivation
R-HSA-443475 Phosphorylation of CREB by CaMKII
R-HSA-442726 Raf activation
R-HSA-432172 Activation of NMDA receptor
R-HSA-432162 Unblocking of NMDA receptor
R-HSA-909552 Phosphorylation of STAT1 at Ser727
R-HSA-442760 Activation of RasGRF
R-HSA-432164 Ca2+ influx into the post-synaptic cell
R-HSA-442732 Ras activation
R-HSA-5672965 RAS GEFs promote RAS nucleotide exchange
R-HSA-4086398 Ca2+ pathway
R-HSA-442729 CREB phosphorylation through the activation of CaMKII
R-HSA-3858494 Beta-catenin independent WNT signaling
R-HSA-399719 Trafficking of AMPA receptors
R-HSA-438064 Post NMDA receptor activation events
R-HSA-3371571 HSF1-dependent transactivation
R-HSA-442742 CREB phosphorylation through the activation of Ras
R-HSA-195721 Signaling by WNT
R-HSA-399721 Glutamate binding, activation of AMPA receptors and synaptic plasticity
R-HSA-438066 Unblocking of NMDA receptor, glutamate binding and activation
R-HSA-442755 Activation of NMDA receptor and postsynaptic events
R-HSA-3371556 Cellular response to heat stress
R-HSA-877300 Interferon gamma signaling
R-HSA-162582 Signal Transduction
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
R-HSA-442982 Ras activation upon Ca2+ influx through NMDA receptor
R-HSA-2262752 Cellular responses to stress
R-HSA-913531 Interferon Signaling
R-HSA-112315 Transmission across Chemical Synapses
R-HSA-8953897 Cellular responses to external stimuli
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-112316 Neuronal System
R-HSA-168256 Immune System
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-5684996 MAPK1/MAPK3 signaling
R-HSA-5683057 MAPK family signaling cascades

-  Other Names for This Gene
  Alternate Gene Symbols: CAMKA, KCC2A_HUMAN, KIAA0968, NM_015981, Q9UL21, Q9UQM7, Q9Y2H4, Q9Y352, uc329whm.1, uc329whm.2
UCSC ID: ENST00000671881.1_13
RefSeq Accession: NM_015981.4
Protein: Q9UQM7 (aka KCC2A_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.