Human Gene CALM2 (ENST00000272298.12_7) from GENCODE V47lift37

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Description: calmodulin 2, transcript variant 2 (from RefSeq NM_001743.6)
Gencode Transcript: ENST00000272298.12_7
Gencode Gene: ENSG00000143933.20_13
Transcript (Including UTRs)
Position: hg19 chr2:47,387,223-47,403,650 Size: 16,428 Total Exon Count: 6 Strand: -
Coding Region
Position: hg19 chr2:47,387,915-47,403,582 Size: 15,668 Coding Exon Count: 6

Page Index	Sequence and Links	Primers	MalaCards	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Other Species	mRNA Descriptions	Pathways
Other Names	GeneReviews	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr2:47,387,223-47,403,650)			mRNA (may differ from genome)		Protein (149 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	OMIM	PubMed	UniProtKB
Wikipedia	BioGrid CRISPR DB

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: CALM2 Diseases sorted by gene-association score: long qt syndrome 15* (1335), long qt syndrome 1* (101), brugada syndrome* (101), phencyclidine abuse (22), catecholaminergic polymorphic ventricular tachycardia* (21), long qt syndrome (18), otomycosis (9), external ear disease (9), cardiomyopathy, dilated, 1p (8), otitis externa (8), leber congenital amaurosis 2 (8), acute dacryocystitis (7), primary cutaneous amyloidosis (7), primary systemic mycosis (7), deafness, autosomal recessive 44 (7), sporotrichosis (6), hemolytic anemia due to triosephosphate isomerase deficiency (6), dystonia 24 (6), spontaneous ocular nystagmus (6), cardiomyopathy, dilated, 1a (5), proliferative fasciitis (4), clear cell acanthoma (4), low compliance bladder (4), deafness, autosomal dominant 2a (4), cardiac arrest (3) * = Manually curated disease association

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D013749 Tetrachlorodibenzodioxin D014635 Valproic Acid C023514 2,6-dinitrotoluene D000661 Amphetamine D001564 Benzo(a)pyrene D002101 Cacodylic Acid D002186 Cannabinoids D002995 Clofibric Acid D003024 Clozapine D003042 Cocaine more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 872.33 RPKM in Brain - Frontal Cortex (BA9) Total median expression: 19203.30 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-17.60	68	-0.259	Picture	PostScript	Text
3' UTR	-140.50	692	-0.203	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	Genome Browser	Genome Browser
			Gene Details	Gene Details	Gene Details
			Gene Sorter	Gene Sorter	Gene Sorter
		Ensembl		WormBase	SGD
				Protein Sequence	Protein Sequence
				Alignment	Alignment

Descriptions from all associated GenBank mRNAs


	AK309369 - Homo sapiens cDNA, FLJ99410. JC051454 - Sequence 6 from Patent WO2013153214. BC047553 - Homo sapiens calmodulin 2 (phosphorylase kinase, delta), mRNA (cDNA clone IMAGE:5302800), with apparent retained intron. BC003354 - Homo sapiens calmodulin 2 (phosphorylase kinase, delta), mRNA (cDNA clone MGC:5226 IMAGE:2899899), complete cds. BC008437 - Homo sapiens calmodulin 2 (phosphorylase kinase, delta), mRNA (cDNA clone MGC:14639 IMAGE:4092978), complete cds. BC017385 - Homo sapiens calmodulin 2 (phosphorylase kinase, delta), mRNA (cDNA clone MGC:22803 IMAGE:3681165), complete cds. D45887 - Homo sapiens mRNA for calmodulin, complete cds. BC006464 - Homo sapiens calmodulin 2 (phosphorylase kinase, delta), mRNA (cDNA clone MGC:2168 IMAGE:3542044), complete cds. AK055130 - Homo sapiens cDNA FLJ30568 fis, clone BRAWH2005517, highly similar to CALMODULIN. M19311 - Human calmodulin mRNA, complete cds. BC026065 - Homo sapiens calmodulin 2 (phosphorylase kinase, delta), mRNA (cDNA clone MGC:22809 IMAGE:3683323), complete cds. BC018677 - Homo sapiens calmodulin 2 (phosphorylase kinase, delta), mRNA (cDNA clone MGC:27282 IMAGE:4656551), complete cds. JD040667 - Sequence 21691 from Patent EP1572962. JD452511 - Sequence 433535 from Patent EP1572962. JD188168 - Sequence 169192 from Patent EP1572962. JD161065 - Sequence 142089 from Patent EP1572962. JD449717 - Sequence 430741 from Patent EP1572962. DL491520 - Novel nucleic acids. JD506379 - Sequence 487403 from Patent EP1572962. DL490129 - Novel nucleic acids. CR541990 - Homo sapiens full open reading frame cDNA clone RZPDo834B0735D for gene CALM2, calmodulin 2 (phosphorylase kinase, delta); complete cds, incl. stopcodon. E09262 - cDNA encoding human calmodulin. AK315694 - Homo sapiens cDNA, FLJ96792, highly similar to Homo sapiens calmodulin 2 (phosphorylase kinase, delta) (CALM2), mRNA. CU678438 - Synthetic construct Homo sapiens gateway clone IMAGE:100017931 5' read CALM2 mRNA. KJ890813 - Synthetic construct Homo sapiens clone ccsbBroadEn_00207 CALM2 gene, encodes complete protein. KJ896534 - Synthetic construct Homo sapiens clone ccsbBroadEn_05928 CALM2 gene, encodes complete protein. KJ905154 - Synthetic construct Homo sapiens clone ccsbBroadEn_14559 CALM2 gene, encodes complete protein. KJ905702 - Synthetic construct Homo sapiens clone ccsbBroadEn_15372 CALM2 gene, encodes complete protein. BT009916 - Homo sapiens calmodulin 2 (phosphorylase kinase, delta) mRNA, complete cds. AB529204 - Synthetic construct DNA, clone: pF1KE1002, Homo sapiens CALM2 gene for calmodulin 2, without stop codon, in Flexi system. CR542021 - Homo sapiens full open reading frame cDNA clone RZPDo834F0635D for gene CALM2, calmodulin 2 (phosphorylase kinase, delta); complete cds, without stopcodon. LF379980 - JP 2014500723-A/187483: Polycomb-Associated Non-Coding RNAs. JD079784 - Sequence 60808 from Patent EP1572962. MA615557 - JP 2018138019-A/187483: Polycomb-Associated Non-Coding RNAs.

Biochemical and Signaling Pathways


	BioCarta from NCI Cancer Genome Anatomy Project h_nfatPathway - NFAT and Hypertrophy of the heart (Transcription in the broken heart) h_pgc1aPathway - Regulation of PGC-1a h_tcrPathway - T Cell Receptor Signaling Pathway h_bcrPathway - BCR Signaling Pathway h_gcrPathway - Corticosteroids and cardioprotection h_gpcrPathway - Signaling Pathway from G-Protein Families h_pyk2Pathway - Links between Pyk2 and Map Kinases h_calcineurinPathway - Effects of calcineurin in Keratinocyte Differentiation h_hdacPathway - Control of skeletal myogenesis by HDAC & calcium/calmodulin-dependent kinase (CaMK) h_fMLPpathway - fMLP induced chemokine gene expression in HMC-1 cells h_mef2dPathway - Role of MEF2D in T-cell Apoptosis h_At1rPathway - Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling h_CaCaMPathway - Ca++/ Calmodulin-dependent Protein Kinase Activation h_biopeptidesPathway - Bioactive Peptide Induced Signaling Pathway h_fcer1Pathway - Fc Epsilon Receptor I Signaling in Mast Cells h_nos1Pathway - Nitric Oxide Signaling Pathway h_vipPathway - Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cells h_ndkDynaminPathway - Endocytotic role of NDK, Phosphins and Dynamin h_Ccr5Pathway - Pertussis toxin-insensitive CCR5 Signaling in Macrophage h_no1Pathway - Actions of Nitric Oxide in the Heart

Other Names for This Gene


	Alternate Gene Symbols: CALM2 , CALM2_HUMAN, CAM2, CAMB, ENST00000272298.1, ENST00000272298.10, ENST00000272298.11, ENST00000272298.2, ENST00000272298.3, ENST00000272298.4, ENST00000272298.5, ENST00000272298.6, ENST00000272298.7, ENST00000272298.8, ENST00000272298.9, NM_001743, P02593, P0DP24, P62158, P70667, P99014, Q13942, Q53S29, Q61379, Q61380, Q96HK3, uc317iyg.1, uc317iyg.2 UCSC ID: ENST00000272298.12_7 RefSeq Accession: NM_001743.6

GeneReviews for This Gene


	GeneReviews article(s) related to gene CALM2: cvt (Catecholaminergic Polymorphic Ventricular Tachycardia) rws (Long QT Syndrome Overview)

Gene Model Information


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Methods, Credits, and Use Restrictions


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