ID:CALCR_HUMAN DESCRIPTION: RecName: Full=Calcitonin receptor; Short=CT-R; Flags: Precursor; FUNCTION: This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin. SUBUNIT: Interacts with GPRASP2. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. POLYMORPHISM: Genetic variations in CALCR may be correlated with bone mineral density (BMD). Low BMD is a risk factor for osteoporotic fracture. Osteoporosis is characterized by reduced bone mineral density, disrutption of bone microarchitecture, and the alteration of the amount and variety of non-collagenous proteins in bone. Osteoporotic bones are more at risk of fracture. SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 81321 - Family A G protein-coupled receptor-like 111418 - Hormone receptor domain
ModBase Predicted Comparative 3D Structure on P30988
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0007165 signal transduction GO:0007166 cell surface receptor signaling pathway GO:0007186 G-protein coupled receptor signaling pathway GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007204 positive regulation of cytosolic calcium ion concentration GO:0010628 positive regulation of gene expression GO:0010739 positive regulation of protein kinase A signaling GO:0010942 positive regulation of cell death GO:0030816 positive regulation of cAMP metabolic process GO:0033138 positive regulation of peptidyl-serine phosphorylation GO:0038041 cross-receptor inhibition within G-protein coupled receptor heterodimer GO:0045762 positive regulation of adenylate cyclase activity GO:0051384 response to glucocorticoid GO:0051897 positive regulation of protein kinase B signaling GO:0070374 positive regulation of ERK1 and ERK2 cascade GO:0097647 amylin receptor signaling pathway GO:1905665 positive regulation of calcium ion import across plasma membrane GO:0007190 activation of adenylate cyclase activity GO:0007202 activation of phospholipase C activity
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
