Human Gene CALCA (ENST00000331587.9_8) from GENCODE V47lift37
  Description: calcitonin related polypeptide alpha, transcript variant 1 (from RefSeq NM_001741.3)
Gencode Transcript: ENST00000331587.9_8
Gencode Gene: ENSG00000110680.14_10
Transcript (Including UTRs)
   Position: hg19 chr11:14,990,047-14,993,897 Size: 3,851 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg19 chr11:14,990,345-14,992,738 Size: 2,394 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:14,990,047-14,993,897)mRNA (may differ from genome)Protein (141 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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HGNCMalacardsMGIOMIMPubMedReactome
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-  Comments and Description Text from UniProtKB
  ID: CALC_HUMAN
DESCRIPTION: RecName: Full=Calcitonin; Contains: RecName: Full=Calcitonin; Contains: RecName: Full=Katacalcin; AltName: Full=Calcitonin carboxyl-terminal peptide; Short=CCP; AltName: Full=PDN-21; Flags: Precursor;
FUNCTION: Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones.
FUNCTION: Katacalcin is a potent plasma calcium-lowering peptide.
INTERACTION: P79222-1:CALCR (xeno); NbExp=1; IntAct=EBI-1018474, EBI-1188415;
SUBCELLULAR LOCATION: Secreted.
SIMILARITY: Belongs to the calcitonin family.
WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/calca/";
WEB RESOURCE: Name=Wikipedia; Note=Calcitonin entry; URL="http://en.wikipedia.org/wiki/Calcitonin";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: CALCA
Diseases sorted by gene-association score: reflex sympathetic dystrophy (43), complex regional pain syndrome (34), spinal stenosis (29), medullary thyroid carcinoma, familial (25), giant cell reparative granuloma (23), idiopathic juvenile osteoporosis (21), multiple endocrine neoplasia iia (20), osteoporosis (20), thyroid cancer (19), neuroendocrine tumor (19), cluster headache (18), paroxysmal hemicrania (18), glucocorticoid-induced osteoporosis (18), sepsis in premature infants (18), discitis (18), cerebral arteriosclerosis (18), pancreatic somatostatinoma (15), mucoepidermoid thyroid carcinoma (15), paget's disease of bone (15), multiple endocrine neoplasia (15), papillary carcinoma (14), somatostatinoma (14), hashimoto thyroiditis (14), osteitis fibrosa (14), islet cell tumor (13), burn scar (12), multiple endocrine neoplasia iib (12), craniometaphyseal dysplasia (12), engraftment syndrome (12), thyroiditis (12), multinodular goiter (12), bone giant cell tumor (12), renal osteodystrophy (11), hyperparathyroidism (11), causalgia (11), osteomalacia (11), acute thyroiditis (11), follicular adenoma (10), algoneurodystrophy (10), pancreatic islet cell tumors (10), epispadias (10), hypercalcemia, infantile, 1 (10), gastric neuroendocrine tumor (10), bone remodeling disease (10), hyperparathyroidism, familial primary (10), bone resorption disease (10), goiter (10), parathyroid carcinoma (10), urticaria pigmentosa (9), nervous system cancer (9), thyroid cancer, nonmedullary, 2 (9), giant cell tumor (9), diabetic foot ulcers (9), root resorption (9), tympanosclerosis (9), impetigo (9), nodular goiter (9), vipoma (9), carcinoid syndrome (9), wdha syndrome (8), mucoepidermoid carcinoma (8), mineral metabolism disease (8), basilar artery insufficiency (8), fibrogenesis imperfecta ossium (8), bullous impetigo (8), small cell carcinoma (8), paraganglioma (8), fibrous dysplasia (8), suppurative thyroiditis (8), secondary hyperparathyroidism of renal origin (8), paget disease of bone 5, juvenile-onset (8), small cell cancer of the lung, somatic (7), hemiplegic migraine (7), chronic pyelonephritis (7), vasomotor rhinitis (7), parathyroid adenoma (7), parathyroid gland disease (7), mammary paget's disease (7), hemiplegia (7), erysipelas (7), hypocalcemia, autosomal dominant (7), hypoadrenalism (7), familial hemiplegic migraine (6), pheochromocytoma (6), thyroid sarcoma (6), calcinosis (6), duodenal somatostatinoma (6), alternating hemiplegia of childhood (6), postpartum depression (6), autonomic nervous system disease (6), nontoxic goiter (6), bacteremia (6), secondary hypertrophic osteoarthropathy (6), atypical follicular adenoma (6), migraine with or without aura 1 (6), endocrine gland cancer (6), pancreatic cholera (6), glycogen storage disease iiia (5), chief cell adenoma (5), cowden disease (5), prolactin producing pituitary tumor (5), tumoral calcinosis, familial, normophosphatemic (5), degenerative disc disease (5), neuroma (5), craniodiaphyseal dysplasia (5), headache (5), pancreatic cystadenocarcinoma (5), hypophosphatasia, adult (5), aneurysmal bone cysts (5), peroneal nerve paralysis (4), thyroid gland disease (4), metaphyseal chondrodysplasia, murk jansen type (4), amyloid tumor (4), extragonadal seminoma (4), ovarian cystic teratoma (4), diffuse pulmonary fibrosis (4), cloacogenic carcinoma (3), brachial plexus lesion (3), chronic kidney failure (2), pulmonary hypertension (2), tetralogy of fallot (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 1.40 RPKM in Kidney - Cortex
Total median expression: 6.75 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -38.40116-0.331 Picture PostScript Text
3' UTR -82.20298-0.276 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR018360 - Calcitonin_CS
IPR001693 - Calcitonin_peptide-like
IPR021117 - Procalcitonin-like
IPR021116 - Procalcitonin/adrenomedullin
IPR021118 - Procalcitonin_A-typ

Pfam Domains:
PF00214 - Calcitonin / CGRP / IAPP family

Protein Data Bank (PDB) 3-D Structure
MuPIT help
2JXZ - NMR


ModBase Predicted Comparative 3D Structure on P01258
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005102 receptor binding
GO:0005179 hormone activity
GO:0005515 protein binding
GO:0031716 calcitonin receptor binding
GO:0042802 identical protein binding

Biological Process:
GO:0001984 vasodilation of artery involved in baroreceptor response to increased systemic arterial blood pressure
GO:0002027 regulation of heart rate
GO:0002548 monocyte chemotaxis
GO:0006874 cellular calcium ion homeostasis
GO:0006954 inflammatory response
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007190 activation of adenylate cyclase activity
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007218 neuropeptide signaling pathway
GO:0007566 embryo implantation
GO:0007568 aging
GO:0007631 feeding behavior
GO:0008016 regulation of heart contraction
GO:0009408 response to heat
GO:0010469 regulation of receptor activity
GO:0030279 negative regulation of ossification
GO:0031645 negative regulation of neurological system process
GO:0032147 activation of protein kinase activity
GO:0042311 vasodilation
GO:0044267 cellular protein metabolic process
GO:0045776 negative regulation of blood pressure
GO:0045778 positive regulation of ossification
GO:0045779 negative regulation of bone resorption
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045986 negative regulation of smooth muscle contraction
GO:0048265 response to pain
GO:0050965 detection of temperature stimulus involved in sensory perception of pain
GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
GO:0071356 cellular response to tumor necrosis factor
GO:1990090 cellular response to nerve growth factor stimulus

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0030424 axon
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0043195 terminal bouton


-  Descriptions from all associated GenBank mRNAs
  LF207863 - JP 2014500723-A/15366: Polycomb-Associated Non-Coding RNAs.
X02330 - Homo sapiens mRNA for calcitonin and calcitonin gene related peptide (CGRP).
M64486 - Human calcitonin (CALCA) mRNA, complete cds.
K03512 - Human calcitonin gene related peptide mRNA, partial cds.
X00356 - Human calcitonin precursor mRNA Calcitonin (CT) is a hypocalcemic hypophosphatemic hormone.
JD161428 - Sequence 142452 from Patent EP1572962.
M26095 - Human calcitonin mRNA, complete cds.
X03662 - Human BEN lung carcinoma cell line mRNA for high-M(r) calcitonin.
BC069684 - Homo sapiens calcitonin-related polypeptide alpha, mRNA (cDNA clone MGC:97315 IMAGE:7262564), complete cds.
BC069704 - Homo sapiens calcitonin-related polypeptide alpha, mRNA (cDNA clone MGC:97232 IMAGE:7262481), complete cds.
BC069760 - Homo sapiens calcitonin-related polypeptide alpha, mRNA (cDNA clone MGC:97244 IMAGE:7262493), complete cds.
BC069778 - Homo sapiens calcitonin-related polypeptide alpha, mRNA (cDNA clone MGC:97256 IMAGE:7262505), complete cds.
LF369585 - JP 2014500723-A/177088: Polycomb-Associated Non-Coding RNAs.
JD064883 - Sequence 45907 from Patent EP1572962.
JD449912 - Sequence 430936 from Patent EP1572962.
BC093753 - Homo sapiens calcitonin-related polypeptide alpha, mRNA (cDNA clone MGC:120788 IMAGE:7939598), complete cds.
BC101599 - Homo sapiens calcitonin-related polypeptide alpha, mRNA (cDNA clone MGC:126648 IMAGE:8069105), complete cds.
BC143562 - Homo sapiens calcitonin-related polypeptide alpha, mRNA (cDNA clone MGC:177090 IMAGE:9052073), complete cds.
JD130201 - Sequence 111225 from Patent EP1572962.
JD325147 - Sequence 306171 from Patent EP1572962.
KJ890810 - Synthetic construct Homo sapiens clone ccsbBroadEn_00204 CALCA gene, encodes complete protein.
HQ448410 - Synthetic construct Homo sapiens clone IMAGE:100071837; CCSB014006_01 calcitonin/calcitonin-related polypeptide, alpha (CALCA) gene, encodes complete protein.
K03513 - Human calcitonin mRNA, partial.
LF212147 - JP 2014500723-A/19650: Polycomb-Associated Non-Coding RNAs.
LF369589 - JP 2014500723-A/177092: Polycomb-Associated Non-Coding RNAs.
LF213101 - JP 2014500723-A/20604: Polycomb-Associated Non-Coding RNAs.
MA605162 - JP 2018138019-A/177088: Polycomb-Associated Non-Coding RNAs.
MA605166 - JP 2018138019-A/177092: Polycomb-Associated Non-Coding RNAs.
MA443440 - JP 2018138019-A/15366: Polycomb-Associated Non-Coding RNAs.
MA447724 - JP 2018138019-A/19650: Polycomb-Associated Non-Coding RNAs.
MA448678 - JP 2018138019-A/20604: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P01258 (Reactome details) participates in the following event(s):

R-HSA-419843 Calcitonin receptor binds calcitonin
R-HSA-744886 The Ligand:GPCR:Gs complex dissociates
R-HSA-744887 Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs
R-HSA-379044 Liganded Gs-activating GPCR acts as a GEF for Gs
R-HSA-419812 Calcitonin-like ligand receptors
R-HSA-418555 G alpha (s) signalling events
R-HSA-373080 Class B/2 (Secretin family receptors)
R-HSA-388396 GPCR downstream signalling
R-HSA-977225 Amyloid fiber formation
R-HSA-500792 GPCR ligand binding
R-HSA-372790 Signaling by GPCR
R-HSA-392499 Metabolism of proteins
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: B7ZL39, CALC1, CALC_HUMAN, ENST00000331587.1, ENST00000331587.2, ENST00000331587.3, ENST00000331587.4, ENST00000331587.5, ENST00000331587.6, ENST00000331587.7, ENST00000331587.8, NM_001741, P01258, Q13935, Q13937, Q52LX7, uc317tgi.1, uc317tgi.2
UCSC ID: ENST00000331587.9_8
RefSeq Accession: NM_001741.3
Protein: P01258 (aka CALC_HUMAN or CAL0_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.