ID:CA2D1_HUMAN DESCRIPTION: RecName: Full=Voltage-dependent calcium channel subunit alpha-2/delta-1; AltName: Full=Voltage-gated calcium channel subunit alpha-2/delta-1; Contains: RecName: Full=Voltage-dependent calcium channel subunit alpha-2-1; Contains: RecName: Full=Voltage-dependent calcium channel subunit delta-1; Flags: Precursor; FUNCTION: The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling (By similarity). SUBUNIT: Dimer formed of alpha-2-1 and delta-1 chains; disulfide- linked. Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1 (CACNA1), alpha-2 (CACNA2D), beta (CACNB) and delta (CACNA2D) subunits in a 1:1:1:1 ratio (By similarity). SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential). TISSUE SPECIFICITY: Isoform 1 is expressed in skeletal muscle. Isoform 2 is expressed in the central nervous system. Isoform 2, isoform 4 and isoform 5 are expressed in neuroblastoma cells. Isoform 3, isoform 4 and isoform 5 are expressed in the aorta. DOMAIN: The MIDAS-like motif in the VWFA domain binds divalent metal cations and is required to promote trafficking of the alpha- 1 (CACNA1) subunit to the plasma membrane by an integrin-like switch (By similarity). PTM: Proteolytically processed into subunits alpha-2-1 and delta-1 that are disulfide-linked (By similarity). MISCELLANEOUS: Binds gabapentin, an antiepileptic drug. SIMILARITY: Belongs to the calcium channel subunit alpha-2/delta family. SIMILARITY: Contains 1 cache domain. SIMILARITY: Contains 1 VWFA domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00092 - von Willebrand factor type A domain PF08399 - VWA N-terminal PF08473 - Neuronal voltage-dependent calcium channel alpha 2acd PF13519 - von Willebrand factor type A domain PF13768 - von Willebrand factor type A domain
ModBase Predicted Comparative 3D Structure on P54289
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005244 voltage-gated ion channel activity GO:0005245 voltage-gated calcium channel activity GO:0005262 calcium channel activity GO:0046872 metal ion binding GO:0086007 voltage-gated calcium channel activity involved in cardiac muscle cell action potential GO:0086057 voltage-gated calcium channel activity involved in bundle of His cell action potential
Biological Process: GO:0006811 ion transport GO:0006816 calcium ion transport GO:0034765 regulation of ion transmembrane transport GO:0051924 regulation of calcium ion transport GO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization GO:0060402 calcium ion transport into cytosol GO:0061577 calcium ion transmembrane transport via high voltage-gated calcium channel GO:0070588 calcium ion transmembrane transport GO:0086002 cardiac muscle cell action potential involved in contraction GO:0086048 membrane depolarization during bundle of His cell action potential GO:0086091 regulation of heart rate by cardiac conduction GO:0098703 calcium ion import across plasma membrane GO:0098903 regulation of membrane repolarization during action potential GO:1901843 positive regulation of high voltage-gated calcium channel activity GO:1902514 regulation of calcium ion transmembrane transport via high voltage-gated calcium channel GO:1904646 cellular response to beta-amyloid
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
