Human Gene BZW1 (ENST00000409600.6_7) from GENCODE V47lift37

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Description: basic leucine zipper and W2 domains 1, transcript variant 4 (from RefSeq NM_014670.4)
Gencode Transcript: ENST00000409600.6_7
Gencode Gene: ENSG00000082153.18_15
Transcript (Including UTRs)
Position: hg19 chr2:201,676,633-201,692,061 Size: 15,429 Total Exon Count: 12 Strand: +
Coding Region
Position: hg19 chr2:201,677,941-201,686,901 Size: 8,961 Coding Exon Count: 11

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species
GO Annotations	mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr2:201,676,633-201,692,061)			mRNA (may differ from genome)		Protein (419 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	PubMed	UniProtKB	Wikipedia
BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: BZW1_HUMAN DESCRIPTION: RecName: Full=Basic leucine zipper and W2 domain-containing protein 1; AltName: Full=Protein Orf; FUNCTION: Enhances histone H4 gene transcription but does not seem to bind DNA directly. INTERACTION: O43586:PSTPIP1; NbExp=2; IntAct=EBI-1046727, EBI-1050964; DEVELOPMENTAL STAGE: Expressed in day 3 embryo. SIMILARITY: Belongs to the BZW family. SIMILARITY: Contains 1 W2 domain. SEQUENCE CAUTION: Sequence=BAA02795.2; Type=Erroneous initiation;

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: BZW1 Diseases sorted by gene-association score: phlebotomus fever (1)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D013749 Tetrachlorodibenzodioxin C028474 1,4-bis(2-(3,5-dichloropyridyloxy))benzene C023514 2,6-dinitrotoluene D015073 2-Acetylaminofluorene C009505 4,4'-diaminodiphenylmethane C027576 4-hydroxy-2-nonenal D000082 Acetaminophen D016604 Aflatoxin B1 D001241 Aspirin D001564 Benzo(a)pyrene D002794 Choline D019327 Copper Sulfate D003993 Dibutyl Phthalate D004041 Dietary Fats D004237 Diuron D004958 Estradiol D004997 Ethinyl Estradiol D005492 Folic Acid D005839 Gentamicins D006997 Hypochlorous Acid D008627 Mercuric Chloride D008715 Methionine D010126 Ozone D012999 Soman D013629 Tamoxifen D014212 Tretinoin C006632 arsenic trioxide C039281 furan C014707 nitrosobenzylmethylamine C060836 pioglitazone C089032 rimonabant C089730 rosiglitazone C009277 sodium arsenate D020122 tert-Butylhydroperoxide C014215 tetrahydropalmatine C015559 trimellitic anhydride C057693 troglitazone

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 30.04 RPKM in Testis Total median expression: 718.84 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-26.70	91	-0.293	Picture	PostScript	Text
3' UTR	-1321.30	5160	-0.256	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR016024 - ARM-type_fold
IPR016021 - MIF4-like_typ_1/2/3
IPR003307 - W2_domain

Pfam Domains:
PF02020 - eIF4-gamma/eIF5/eIF2-epsilon

SCOP Domains:
48371 - ARM repeat

ModBase Predicted Comparative 3D Structure on Q7L1Q6


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0003723 RNA binding GO:0045296 cadherin binding Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated Cellular Component: GO:0005737 cytoplasm GO:0016020 membrane

Descriptions from all associated GenBank mRNAs


	AL833518 - Homo sapiens mRNA; cDNA DKFZp686G1237 (from clone DKFZp686G1237). Z70221 - H.sapiens mRNA for orf (clone ICRFp507F0480). AK096489 - Homo sapiens cDNA FLJ39170 fis, clone OCBBF2003028, highly similar to Rattus norvegicus basic leucine zipper and W2 domains 1 (Bzw1), mRNA. D13630 - Homo sapiens KIAA0005 mRNA. BC001804 - Homo sapiens basic leucine zipper and W2 domains 1, mRNA (cDNA clone MGC:769 IMAGE:3354883), complete cds. BC026303 - Homo sapiens basic leucine zipper and W2 domains 1, mRNA (cDNA clone MGC:24775 IMAGE:4284614), complete cds. AK223245 - Homo sapiens mRNA for BZW1 protein variant, clone: STM04373. JD261414 - Sequence 242438 from Patent EP1572962. AK301511 - Homo sapiens cDNA FLJ55501 complete cds, highly similar to Rattus norvegicus basic leucine zipper and W2 domains 1 (Bzw1), mRNA. AK297227 - Homo sapiens cDNA FLJ55789 complete cds, highly similar to Rattus norvegicus basic leucine zipper and W2 domains 1 (Bzw1), mRNA. AB590046 - Synthetic construct DNA, clone: pFN21AA0005, Homo sapiens BZW1 gene for basic leucine zipper and W2 domains 1, without stop codon, in Flexi system. CU693202 - Synthetic construct Homo sapiens gateway clone IMAGE:100022315 5' read BZW1 mRNA. DQ893228 - Synthetic construct clone IMAGE:100005858; FLH195422.01X; RZPDo839C03152D basic leucine zipper and W2 domains 1 (BZW1) gene, encodes complete protein. DQ896557 - Synthetic construct Homo sapiens clone IMAGE:100011017; FLH195418.01L; RZPDo839C03151D basic leucine zipper and W2 domains 1 (BZW1) gene, encodes complete protein. KJ902010 - Synthetic construct Homo sapiens clone ccsbBroadEn_11404 BZW1 gene, encodes complete protein. AB074176 - Homo sapiens primary neuroblastoma cDNA, clone:Nbla10236, full insert sequence. JD243463 - Sequence 224487 from Patent EP1572962. JD280202 - Sequence 261226 from Patent EP1572962. JD094475 - Sequence 75499 from Patent EP1572962. JD424644 - Sequence 405668 from Patent EP1572962. JD315413 - Sequence 296437 from Patent EP1572962. JD330613 - Sequence 311637 from Patent EP1572962. JD081700 - Sequence 62724 from Patent EP1572962. JD516165 - Sequence 497189 from Patent EP1572962. JD324133 - Sequence 305157 from Patent EP1572962. JD423048 - Sequence 404072 from Patent EP1572962. JD250705 - Sequence 231729 from Patent EP1572962. JD196986 - Sequence 178010 from Patent EP1572962. JD546100 - Sequence 527124 from Patent EP1572962. JD222010 - Sequence 203034 from Patent EP1572962. JD022747 - Sequence 3771 from Patent EP1572962. JD032160 - Sequence 13184 from Patent EP1572962. JD213284 - Sequence 194308 from Patent EP1572962. JD152329 - Sequence 133353 from Patent EP1572962. JD256833 - Sequence 237857 from Patent EP1572962. JD407653 - Sequence 388677 from Patent EP1572962. JD213285 - Sequence 194309 from Patent EP1572962. JD059656 - Sequence 40680 from Patent EP1572962. JD405604 - Sequence 386628 from Patent EP1572962. JD405605 - Sequence 386629 from Patent EP1572962. JD405606 - Sequence 386630 from Patent EP1572962. JD457299 - Sequence 438323 from Patent EP1572962. JD457300 - Sequence 438324 from Patent EP1572962. JD457301 - Sequence 438325 from Patent EP1572962. AF086164 - Homo sapiens full length insert cDNA clone ZB81B12.

Other Names for This Gene


	Alternate Gene Symbols: 5MP2 , 5MP2_HUMAN, B4DLZ8, B4DWF7, BZAP45, ENST00000409600.1, ENST00000409600.2, ENST00000409600.3, ENST00000409600.4, ENST00000409600.5, KIAA0005, NM_014670, Q14281, Q15394, Q7L1Q6, Q9BUY0, uc319fyb.1, uc319fyb.2 UCSC ID: ENST00000409600.6_7 RefSeq Accession: NM_001207067.2 Protein: Q7L1Q6 (aka BZW1_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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