ID:BOK_HUMAN DESCRIPTION: RecName: Full=Bcl-2-related ovarian killer protein; Short=hBOK; AltName: Full=Bcl-2-like protein 9; Short=Bcl2-L-9; FUNCTION: May play a role in apoptosis. TISSUE SPECIFICITY: Expressed in brain, liver, appendix and lymphoid tissues. SIMILARITY: Belongs to the Bcl-2 family. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/BOKID824ch2q37.html";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00452 - Apoptosis regulator proteins, Bcl-2 family
SCOP Domains: 56854 - Bcl-2 inhibitors of programmed cell death
ModBase Predicted Comparative 3D Structure on Q9UMX3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005102 receptor binding GO:0005515 protein binding GO:0031625 ubiquitin protein ligase binding GO:0042803 protein homodimerization activity GO:0046982 protein heterodimerization activity GO:0046983 protein dimerization activity GO:0051400 BH domain binding
Biological Process: GO:0001836 release of cytochrome c from mitochondria GO:0006915 apoptotic process GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006921 cellular component disassembly involved in execution phase of apoptosis GO:0007420 brain development GO:0008283 cell proliferation GO:0008584 male gonad development GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c GO:0010506 regulation of autophagy GO:0042981 regulation of apoptotic process GO:0043065 positive regulation of apoptotic process GO:0043524 negative regulation of neuron apoptotic process GO:0048709 oligodendrocyte differentiation GO:0051259 protein oligomerization GO:0051402 neuron apoptotic process GO:0051480 regulation of cytosolic calcium ion concentration GO:0051902 negative regulation of mitochondrial depolarization GO:0060546 negative regulation of necroptotic process GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand GO:1900119 positive regulation of execution phase of apoptosis GO:1901029 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway GO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway GO:1901382 regulation of chorionic trophoblast cell proliferation GO:1902237 positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway GO:1903899 positive regulation of PERK-mediated unfolded protein response GO:1904708 regulation of granulosa cell apoptotic process GO:2001244 positive regulation of intrinsic apoptotic signaling pathway
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
