Human Gene BIN3 (ENST00000276416.11_7) from GENCODE V47lift37
  Description: bridging integrator 3, transcript variant 3 (from RefSeq NR_156436.2)
Gencode Transcript: ENST00000276416.11_7
Gencode Gene: ENSG00000147439.14_16
Transcript (Including UTRs)
   Position: hg19 chr8:22,477,931-22,526,634 Size: 48,704 Total Exon Count: 9 Strand: -
Coding Region
   Position: hg19 chr8:22,478,935-22,526,564 Size: 47,630 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr8:22,477,931-22,526,634)mRNA (may differ from genome)Protein (253 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: BIN3_HUMAN
DESCRIPTION: RecName: Full=Bridging integrator 3;
FUNCTION: Involved in cytokinesis and septation where it has a role in the localization of F-actin.
INTERACTION: Q6XZF7:DNMBP; NbExp=2; IntAct=EBI-2653038, EBI-2483419;
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
TISSUE SPECIFICITY: Ubiquitously expressed except in brain.
SIMILARITY: Contains 1 BAR domain.
SEQUENCE CAUTION: Sequence=AAH01223.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 14.28 RPKM in Adrenal Gland
Total median expression: 353.52 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -15.3070-0.219 Picture PostScript Text
3' UTR -401.401004-0.400 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR004148 - BAR_dom

Pfam Domains:
PF03114 - BAR domain
PF09325 - Vps5 C terminal like

SCOP Domains:
103657 - BAR/IMD domain-like
116742 - eIF2alpha middle domain-like

ModBase Predicted Comparative 3D Structure on Q9NQY0
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologGenome Browser
Gene DetailsGene Details   Gene Details
Gene SorterGene Sorter   Gene Sorter
 RGDEnsembl  SGD
     Protein Sequence
     Alignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0008093 cytoskeletal adaptor activity

Biological Process:
GO:0000917 barrier septum assembly
GO:0007015 actin filament organization
GO:0007049 cell cycle
GO:0008104 protein localization
GO:0009826 unidimensional cell growth
GO:0010591 regulation of lamellipodium assembly
GO:0014839 myoblast migration involved in skeletal muscle regeneration
GO:0043403 skeletal muscle tissue regeneration
GO:0048741 skeletal muscle fiber development
GO:0051301 cell division
GO:0061640 cytoskeleton-dependent cytokinesis

Cellular Component:
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005884 actin filament


-  Descriptions from all associated GenBank mRNAs
  AK090446 - Homo sapiens mRNA for FLJ00367 protein.
BC009824 - Homo sapiens bridging integrator 3, mRNA (cDNA clone MGC:14978 IMAGE:3953604), complete cds.
AK124486 - Homo sapiens cDNA FLJ42495 fis, clone BRACE2034870, highly similar to Homo sapiens bridging integrator 3 (BIN3).
JD468535 - Sequence 449559 from Patent EP1572962.
JD146076 - Sequence 127100 from Patent EP1572962.
JD481712 - Sequence 462736 from Patent EP1572962.
JD231726 - Sequence 212750 from Patent EP1572962.
AK001289 - Homo sapiens cDNA FLJ10427 fis, clone NT2RP1000348, weakly similar to REDUCED VIABILITY UPON STARVATION PROTEIN 161.
BC050314 - Homo sapiens bridging integrator 3, mRNA (cDNA clone IMAGE:4812253), with apparent retained intron.
BC001223 - Homo sapiens bridging integrator 3, mRNA (cDNA clone MGC:967 IMAGE:3534031), complete cds.
AF271732 - Homo sapiens bridging integrator-3 mRNA, complete cds.
AK023980 - Homo sapiens cDNA FLJ13918 fis, clone Y79AA1000368, weakly similar to REDUCED VIABILITY UPON STARVATION PROTEIN 161.
JD513092 - Sequence 494116 from Patent EP1572962.
JD391716 - Sequence 372740 from Patent EP1572962.
JD394340 - Sequence 375364 from Patent EP1572962.
JD063577 - Sequence 44601 from Patent EP1572962.
JD192295 - Sequence 173319 from Patent EP1572962.
JD475076 - Sequence 456100 from Patent EP1572962.
JD132317 - Sequence 113341 from Patent EP1572962.
JD205029 - Sequence 186053 from Patent EP1572962.
JD443282 - Sequence 424306 from Patent EP1572962.
JD132105 - Sequence 113129 from Patent EP1572962.
JD156174 - Sequence 137198 from Patent EP1572962.
JD174359 - Sequence 155383 from Patent EP1572962.
JD247835 - Sequence 228859 from Patent EP1572962.
JD513080 - Sequence 494104 from Patent EP1572962.
AK222470 - Homo sapiens mRNA for bridging integrator 3 variant, clone: adKA02467.
JD289920 - Sequence 270944 from Patent EP1572962.
DQ591423 - Homo sapiens piRNA piR-58535, complete sequence.
KJ902895 - Synthetic construct Homo sapiens clone ccsbBroadEn_12289 BIN3 gene, encodes complete protein.
CU674616 - Synthetic construct Homo sapiens gateway clone IMAGE:100020642 5' read BIN3 mRNA.
HQ447205 - Synthetic construct Homo sapiens clone IMAGE:100070502; CCSB006626_01 bridging integrator 3 (BIN3) gene, encodes complete protein.
KJ899215 - Synthetic construct Homo sapiens clone ccsbBroadEn_08609 BIN3 gene, encodes complete protein.
JD054780 - Sequence 35804 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: BIN3_HUMAN, ENST00000276416.1, ENST00000276416.10, ENST00000276416.2, ENST00000276416.3, ENST00000276416.4, ENST00000276416.5, ENST00000276416.6, ENST00000276416.7, ENST00000276416.8, ENST00000276416.9, NR_156436, Q9BVG2, Q9NQY0, Q9NVY9, uc317jkj.1, uc317jkj.2
UCSC ID: ENST00000276416.11_7
RefSeq Accession: NM_018688.6
Protein: Q9NQY0 (aka BIN3_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.