Human Gene BDKRB2 (ENST00000554311.2_7) from GENCODE V47lift37
  Description: bradykinin receptor B2, transcript variant 1 (from RefSeq NM_001379692.1)
Gencode Transcript: ENST00000554311.2_7
Gencode Gene: ENSG00000168398.7_8
Transcript (Including UTRs)
   Position: hg19 chr14:96,671,176-96,710,501 Size: 39,326 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg19 chr14:96,703,445-96,707,841 Size: 4,397 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr14:96,671,176-96,710,501)mRNA (may differ from genome)Protein (391 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: BKRB2_HUMAN
DESCRIPTION: RecName: Full=B2 bradykinin receptor; Short=B2R; Short=BK-2 receptor;
FUNCTION: Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.
SUBUNIT: Forms a complex with PECAM1 and GNAQ. Interacts with PECAM1.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Ubiquitous. Widespread in normal smooth muscle tissue and neurons.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB2 sub-subfamily.
WEB RESOURCE: Name=Wikipedia; Note=Bradykinin receptor entry; URL="http://en.wikipedia.org/wiki/Bradykinin_receptor";
WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/bdkrb2/";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: BDKRB2
Diseases sorted by gene-association score: brain edema (23), hereditary angioedema (14), retinitis pigmentosa 68 (11), c1 inhibitor deficiency (10), angioedema (10), acute mountain sickness (5), hypertension, essential (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -66.60160-0.416 Picture PostScript Text
3' UTR -883.202660-0.332 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR001504 - B2_bradkn_rcpt
IPR000496 - Brdyknn_rcpt
IPR017452 - GPCR_Rhodpsn_supfam

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)

SCOP Domains:
81321 - Family A G protein-coupled receptor-like

ModBase Predicted Comparative 3D Structure on P30411
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0002020 protease binding
GO:0004435 phosphatidylinositol phospholipase C activity
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0004947 bradykinin receptor activity
GO:0005515 protein binding
GO:0031702 type 1 angiotensin receptor binding
GO:0046982 protein heterodimerization activity

Biological Process:
GO:0006939 smooth muscle contraction
GO:0006950 response to stress
GO:0006954 inflammatory response
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0008015 blood circulation
GO:0009651 response to salt stress
GO:0019229 regulation of vasoconstriction
GO:0033137 negative regulation of peptidyl-serine phosphorylation
GO:0042310 vasoconstriction
GO:0042311 vasodilation
GO:0043114 regulation of vascular permeability
GO:0050482 arachidonic acid secretion
GO:1902219 negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress
GO:1902239 negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator

Cellular Component:
GO:0005768 endosome
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  CR749338 - Homo sapiens mRNA; cDNA DKFZp686O088 (from clone DKFZp686O088).
U35875 - Homo sapiens B2 bradykinin receptor mRNA, 5' sequence.
AK311049 - Homo sapiens cDNA, FLJ18091.
AK299316 - Homo sapiens cDNA FLJ55307 complete cds, highly similar to B2 bradykinin receptor.
KJ950627 - Homo sapiens bradykinin receptor B1 (BDKRB1) mRNA, complete cds.
KJ950628 - Homo sapiens bradykinin receptor B2 (BDKRB2) mRNA, complete cds.
M88714 - Human bradykinin receptor (BK-2) mRNA, complete cds.
LF209640 - JP 2014500723-A/17143: Polycomb-Associated Non-Coding RNAs.
X69680 - H.sapiens mRNA for bradykinin receptor.
JD363652 - Sequence 344676 from Patent EP1572962.
BC074894 - Homo sapiens bradykinin receptor B2, mRNA (cDNA clone MGC:104033 IMAGE:30915477), complete cds.
BC074895 - Homo sapiens bradykinin receptor B2, mRNA (cDNA clone MGC:103866 IMAGE:30915248), complete cds.
AB464469 - Synthetic construct DNA, clone: pF1KB8990, Homo sapiens BDKRB2 gene for bradykinin receptor B2, without stop codon, in Flexi system.
AY275465 - Homo sapiens bradykinin receptor B2 (BDKRB2) mRNA, complete cds.
X86164 - H.sapiens mRNA for B2-bradykinin receptor, C14 allele.
X86165 - H.sapiens mRNA for B2-bradykinin receptor, R14 allele.
X86163 - H.sapiens mRNA for B2-bradykinin receptor, 3'.
JD328786 - Sequence 309810 from Patent EP1572962.
JD173239 - Sequence 154263 from Patent EP1572962.
JD358096 - Sequence 339120 from Patent EP1572962.
JD157545 - Sequence 138569 from Patent EP1572962.
JD300738 - Sequence 281762 from Patent EP1572962.
JD056967 - Sequence 37991 from Patent EP1572962.
JD565252 - Sequence 546276 from Patent EP1572962.
JD559411 - Sequence 540435 from Patent EP1572962.
JD400073 - Sequence 381097 from Patent EP1572962.
JD151363 - Sequence 132387 from Patent EP1572962.
JD472054 - Sequence 453078 from Patent EP1572962.
JD076124 - Sequence 57148 from Patent EP1572962.
JD495635 - Sequence 476659 from Patent EP1572962.
JD435638 - Sequence 416662 from Patent EP1572962.
JD059993 - Sequence 41017 from Patent EP1572962.
LF330350 - JP 2014500723-A/137853: Polycomb-Associated Non-Coding RNAs.
JD160562 - Sequence 141586 from Patent EP1572962.
JD531972 - Sequence 512996 from Patent EP1572962.
JD062595 - Sequence 43619 from Patent EP1572962.
JD044422 - Sequence 25446 from Patent EP1572962.
JD334971 - Sequence 315995 from Patent EP1572962.
JD347097 - Sequence 328121 from Patent EP1572962.
LF330351 - JP 2014500723-A/137854: Polycomb-Associated Non-Coding RNAs.
JD231366 - Sequence 212390 from Patent EP1572962.
JD362924 - Sequence 343948 from Patent EP1572962.
JD494038 - Sequence 475062 from Patent EP1572962.
JD271549 - Sequence 252573 from Patent EP1572962.
JD561031 - Sequence 542055 from Patent EP1572962.
JD464530 - Sequence 445554 from Patent EP1572962.
JD468630 - Sequence 449654 from Patent EP1572962.
JD409536 - Sequence 390560 from Patent EP1572962.
JD396218 - Sequence 377242 from Patent EP1572962.
JD194028 - Sequence 175052 from Patent EP1572962.
JD351903 - Sequence 332927 from Patent EP1572962.
JD093604 - Sequence 74628 from Patent EP1572962.
JD197181 - Sequence 178205 from Patent EP1572962.
JD437042 - Sequence 418066 from Patent EP1572962.
JD322462 - Sequence 303486 from Patent EP1572962.
JD212033 - Sequence 193057 from Patent EP1572962.
JD540358 - Sequence 521382 from Patent EP1572962.
JD400774 - Sequence 381798 from Patent EP1572962.
JD400632 - Sequence 381656 from Patent EP1572962.
JD400644 - Sequence 381668 from Patent EP1572962.
JD121504 - Sequence 102528 from Patent EP1572962.
JD374776 - Sequence 355800 from Patent EP1572962.
JD491100 - Sequence 472124 from Patent EP1572962.
LF330352 - JP 2014500723-A/137855: Polycomb-Associated Non-Coding RNAs.
JD427109 - Sequence 408133 from Patent EP1572962.
JD266785 - Sequence 247809 from Patent EP1572962.
MA565927 - JP 2018138019-A/137853: Polycomb-Associated Non-Coding RNAs.
MA565928 - JP 2018138019-A/137854: Polycomb-Associated Non-Coding RNAs.
MA565929 - JP 2018138019-A/137855: Polycomb-Associated Non-Coding RNAs.
MA445217 - JP 2018138019-A/17143: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_no1Pathway - Actions of Nitric Oxide in the Heart

Reactome (by CSHL, EBI, and GO)

Protein P30411 (Reactome details) participates in the following event(s):

R-HSA-374331 Bradykinin receptors B1 and B2 bind to bradykinin
R-HSA-749454 The Ligand:GPCR:Gi complex dissociates
R-HSA-749452 The Ligand:GPCR:Gq complex dissociates
R-HSA-749456 Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi
R-HSA-749448 Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq
R-HSA-380073 Liganded Gi-activating GPCR acts as a GEF for Gi
R-HSA-379048 Liganded Gq/11-activating GPCRs act as GEFs for Gq/11
R-HSA-375276 Peptide ligand-binding receptors
R-HSA-418594 G alpha (i) signalling events
R-HSA-416476 G alpha (q) signalling events
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-388396 GPCR downstream signalling
R-HSA-500792 GPCR ligand binding
R-HSA-372790 Signaling by GPCR
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: BKR2, BKRB2_HUMAN, ENST00000554311.1, NM_001379692, P30411, uc325fsi.1, uc325fsi.2
UCSC ID: ENST00000554311.2_7
RefSeq Accession: NM_001379692.1
Protein: P30411 (aka BKRB2_HUMAN or BRB2_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.