Human Gene BBX (ENST00000325805.13_7) from GENCODE V47lift37

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Description: BBX high mobility group box domain containing, transcript variant 1 (from RefSeq NM_001142568.3)
Gencode Transcript: ENST00000325805.13_7
Gencode Gene: ENSG00000114439.19_18
Transcript (Including UTRs)
Position: hg19 chr3:107,241,809-107,530,186 Size: 288,378 Total Exon Count: 18 Strand: +
Coding Region
Position: hg19 chr3:107,429,308-107,524,304 Size: 94,997 Coding Exon Count: 15

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species
GO Annotations	mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr3:107,241,809-107,530,186)			mRNA (may differ from genome)		Protein (941 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	PubMed	UniProtKB	Wikipedia
BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: BBX_HUMAN DESCRIPTION: RecName: Full=HMG box transcription factor BBX; AltName: Full=Bobby sox homolog; AltName: Full=HMG box-containing protein 2; FUNCTION: Transcription factor that is necessary for cell cycle progression from G1 to S phase. SUBCELLULAR LOCATION: Nucleus (Probable). SIMILARITY: Contains 1 HMG box DNA-binding domain. SEQUENCE CAUTION: Sequence=AAI10904.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: BBX Diseases sorted by gene-association score: diabetes mellitus, insulin-dependent, 3 (3), diabetes mellitus, insulin-dependent, 5 (1)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D001564 Benzo(a)pyrene D008767 Methylmercury Compounds C016403 2,4-dinitrotoluene C009505 4,4'-diaminodiphenylmethane C035207 4-amino-2,6-dinitrotoluene C027576 4-hydroxy-2-nonenal D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide D000082 Acetaminophen D019256 Cadmium Chloride D002737 Chloroprene more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 19.90 RPKM in Testis Total median expression: 284.70 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-92.20	301	-0.306	Picture	PostScript	Text
3' UTR	-1460.30	5882	-0.248	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR009071 - HMG_superfamily
IPR019102 - TF_HMG_box_BBX_DUF2028

Pfam Domains:
PF00505 - HMG (high mobility group) box
PF09011 - HMG-box domain
PF09667 - Domain of unknown function (DUF2028)

SCOP Domains:
47095 - HMG-box

ModBase Predicted Comparative 3D Structure on Q8WY36


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0003677 DNA binding Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0060348 bone development Cellular Component: GO:0005634 nucleus GO:0005654 nucleoplasm GO:0005829 cytosol

Descriptions from all associated GenBank mRNAs


	AF283775 - Homo sapiens clone TCBAP1028 mRNA sequence. AF454941 - Homo sapiens HMG-box transcription factor BBX (BBX) mRNA, complete cds, alternatively spliced. AF161457 - Homo sapiens HSPC339 mRNA, partial cds. AK314434 - Homo sapiens cDNA, FLJ95231. AK057010 - Homo sapiens cDNA FLJ32448 fis, clone SKMUS2001634, weakly similar to HIGH MOBILITY GROUP PROTEIN HMG2. AK291757 - Homo sapiens cDNA FLJ78675 complete cds, highly similar to Homo sapiens stroma HMG-box containing protein (HBP2) mRNA. AF276949 - Homo sapiens melanocyte HMG-box containing protein (HBP2) mRNA, partial cds. BC131718 - Homo sapiens bobby sox homolog (Drosophila), mRNA (cDNA clone MGC:150613 IMAGE:40123389), complete cds. AL136769 - Homo sapiens mRNA; cDNA DKFZp434I1116 (from clone DKFZp434I1116). AF454942 - Homo sapiens HMG-box transcription factor BBXa (BBX) mRNA, complete cds, alternatively spliced. AK307668 - Homo sapiens cDNA, FLJ97616. BC110903 - Homo sapiens bobby sox homolog (Drosophila), mRNA (cDNA clone IMAGE:6151073), partial cds. AF276948 - Homo sapiens stroma HMG-box containing protein (HBP2) mRNA, complete cds. EU832360 - Synthetic construct Homo sapiens clone HAIB:100067389; DKFZo004A0228 bobby sox homolog (Drosophila) protein (BBX) gene, encodes complete protein. EU832275 - Synthetic construct Homo sapiens clone HAIB:100067304; DKFZo008A0227 bobby sox homolog (Drosophila) protein (BBX) gene, encodes complete protein. KJ902927 - Synthetic construct Homo sapiens clone ccsbBroadEn_12321 BBX gene, encodes complete protein. JD068946 - Sequence 49970 from Patent EP1572962. JD104035 - Sequence 85059 from Patent EP1572962. JD554652 - Sequence 535676 from Patent EP1572962. JD197274 - Sequence 178298 from Patent EP1572962. JD469481 - Sequence 450505 from Patent EP1572962. BC012837 - Homo sapiens bobby sox homolog (Drosophila), mRNA (cDNA clone IMAGE:3857955), partial cds. AK026082 - Homo sapiens cDNA: FLJ22429 fis, clone HRC09084. AK130627 - Homo sapiens cDNA FLJ27117 fis, clone SPL06311. AL834307 - Homo sapiens mRNA; cDNA DKFZp434B1713 (from clone DKFZp434B1713). AK025944 - Homo sapiens cDNA: FLJ22291 fis, clone HRC04410. AF168718 - Homo sapiens x 001 protein mRNA, complete cds. JD455825 - Sequence 436849 from Patent EP1572962. JD109836 - Sequence 90860 from Patent EP1572962. JD247969 - Sequence 228993 from Patent EP1572962. JD071173 - Sequence 52197 from Patent EP1572962. JD356865 - Sequence 337889 from Patent EP1572962. JD092666 - Sequence 73690 from Patent EP1572962. JD340420 - Sequence 321444 from Patent EP1572962. JD362642 - Sequence 343666 from Patent EP1572962. JD259791 - Sequence 240815 from Patent EP1572962. JD265485 - Sequence 246509 from Patent EP1572962. JD235252 - Sequence 216276 from Patent EP1572962. AY527413 - Homo sapiens ARTC1 mRNA, complete sequence. JD353874 - Sequence 334898 from Patent EP1572962. JD207276 - Sequence 188300 from Patent EP1572962. JD119998 - Sequence 101022 from Patent EP1572962. JD565023 - Sequence 546047 from Patent EP1572962. JD078198 - Sequence 59222 from Patent EP1572962. JD046892 - Sequence 27916 from Patent EP1572962. JD449503 - Sequence 430527 from Patent EP1572962. JD553675 - Sequence 534699 from Patent EP1572962. JD557743 - Sequence 538767 from Patent EP1572962. JD530378 - Sequence 511402 from Patent EP1572962. JD562411 - Sequence 543435 from Patent EP1572962. JD551131 - Sequence 532155 from Patent EP1572962. JD314269 - Sequence 295293 from Patent EP1572962. JD539081 - Sequence 520105 from Patent EP1572962. AF052174 - Homo sapiens clone 24630 mRNA sequence. JD307760 - Sequence 288784 from Patent EP1572962. JD351951 - Sequence 332975 from Patent EP1572962. JD471593 - Sequence 452617 from Patent EP1572962. JD377017 - Sequence 358041 from Patent EP1572962. JD324078 - Sequence 305102 from Patent EP1572962. JD314035 - Sequence 295059 from Patent EP1572962. JD174560 - Sequence 155584 from Patent EP1572962. JD313697 - Sequence 294721 from Patent EP1572962. JD504088 - Sequence 485112 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: A2RRM7, BBX_HUMAN, ENST00000325805.1, ENST00000325805.10, ENST00000325805.11, ENST00000325805.12, ENST00000325805.2, ENST00000325805.3, ENST00000325805.4, ENST00000325805.5, ENST00000325805.6, ENST00000325805.7, ENST00000325805.8, ENST00000325805.9, HBP2, NM_001142568, Q2TAJ1, Q7L3J8, Q7LBY8, Q8NDB0, Q8WY35, Q8WY36, Q9H0J6, uc317rxw.1, uc317rxw.2 UCSC ID: ENST00000325805.13_7 RefSeq Accession: NM_001142568.3 Protein: Q8WY36 (aka BBX_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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