ID:BAG5_HUMAN DESCRIPTION: RecName: Full=BAG family molecular chaperone regulator 5; Short=BAG-5; AltName: Full=Bcl-2-associated athanogene 5; FUNCTION: Inhibits both auto-ubiquitination of PARK2 and ubiquitination of target proteins by PARK2 (By similarity). May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding. SUBUNIT: Binds to the ATPase domain of HSP/HSC70 chaperones. Binds PARK2 (By similarity). DOMAIN: The fifth BAG domain is responsible for the interaction with HSP70 nucleotide-binding domain. SIMILARITY: Contains 5 BAG domains. SEQUENCE CAUTION: Sequence=BAA74896.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9UL15
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000774 adenyl-nucleotide exchange factor activity GO:0005515 protein binding GO:0019901 protein kinase binding GO:0031625 ubiquitin protein ligase binding GO:0051087 chaperone binding
Biological Process: GO:0006457 protein folding GO:0007030 Golgi organization GO:0010977 negative regulation of neuron projection development GO:0031397 negative regulation of protein ubiquitination GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0050821 protein stabilization GO:0051438 regulation of ubiquitin-protein transferase activity GO:0051444 negative regulation of ubiquitin-protein transferase activity GO:0061084 negative regulation of protein refolding GO:0070997 neuron death GO:0090083 regulation of inclusion body assembly GO:1900034 regulation of cellular response to heat GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
AB105186 - Homo sapiens BAG5 mRNA for BCL2-associated athanogene 5, complete cds. AK001378 - Homo sapiens cDNA FLJ10516 fis, clone NT2RP2000809, highly similar to Homo sapiens mRNA for KIAA0873 protein. AF095195 - Homo sapiens BAG-family molecular chaperone regulator-5 mRNA, complete cds. AB020680 - Homo sapiens KIAA0873 mRNA for KIAA0873 protein. AK023145 - Homo sapiens cDNA FLJ13083 fis, clone NT2RP3002062, highly similar to Homo sapiens BAG-family molecular chaperone regulator-5 mRNA. JD165965 - Sequence 146989 from Patent EP1572962. JD557886 - Sequence 538910 from Patent EP1572962. JD553527 - Sequence 534551 from Patent EP1572962. JD183754 - Sequence 164778 from Patent EP1572962. JD558022 - Sequence 539046 from Patent EP1572962. JD407228 - Sequence 388252 from Patent EP1572962. JD116612 - Sequence 97636 from Patent EP1572962. JD495875 - Sequence 476899 from Patent EP1572962. JD307562 - Sequence 288586 from Patent EP1572962. JD284453 - Sequence 265477 from Patent EP1572962. JD231287 - Sequence 212311 from Patent EP1572962. JD081631 - Sequence 62655 from Patent EP1572962. JD124307 - Sequence 105331 from Patent EP1572962. JD311829 - Sequence 292853 from Patent EP1572962. JD505512 - Sequence 486536 from Patent EP1572962. JD072134 - Sequence 53158 from Patent EP1572962. JD505510 - Sequence 486534 from Patent EP1572962. JD099712 - Sequence 80736 from Patent EP1572962. JD116304 - Sequence 97328 from Patent EP1572962. JD334439 - Sequence 315463 from Patent EP1572962. JD375728 - Sequence 356752 from Patent EP1572962. JD388777 - Sequence 369801 from Patent EP1572962. JD296702 - Sequence 277726 from Patent EP1572962. JD074274 - Sequence 55298 from Patent EP1572962. JD250545 - Sequence 231569 from Patent EP1572962. JD056511 - Sequence 37535 from Patent EP1572962. JD094023 - Sequence 75047 from Patent EP1572962. JD100181 - Sequence 81205 from Patent EP1572962. JD389376 - Sequence 370400 from Patent EP1572962. JD260105 - Sequence 241129 from Patent EP1572962. JD304238 - Sequence 285262 from Patent EP1572962. CQ873770 - Sequence 189 from Patent WO2004076622. DD413607 - Regulation of Mammalian Cells. JD227937 - Sequence 208961 from Patent EP1572962. JD421253 - Sequence 402277 from Patent EP1572962. JD198898 - Sequence 179922 from Patent EP1572962. JD502816 - Sequence 483840 from Patent EP1572962. JD469627 - Sequence 450651 from Patent EP1572962. JD322689 - Sequence 303713 from Patent EP1572962. JD504695 - Sequence 485719 from Patent EP1572962. JD058754 - Sequence 39778 from Patent EP1572962. JD503176 - Sequence 484200 from Patent EP1572962. JD083809 - Sequence 64833 from Patent EP1572962. JD082882 - Sequence 63906 from Patent EP1572962. JD403941 - Sequence 384965 from Patent EP1572962. JD565920 - Sequence 546944 from Patent EP1572962. JD551179 - Sequence 532203 from Patent EP1572962. JD066945 - Sequence 47969 from Patent EP1572962. AK291312 - Homo sapiens cDNA FLJ77290 complete cds, highly similar to Homo sapiens BCL2-associated athanogene 5 (BAG5), mRNA. BC044216 - Homo sapiens BCL2-associated athanogene 5, mRNA (cDNA clone MGC:49902 IMAGE:5745133), complete cds. AK225730 - Homo sapiens mRNA for BCL2-associated athanogene 5 isoform a variant, clone: TST01208. BC050551 - Homo sapiens BCL2-associated athanogene 5, mRNA (cDNA clone MGC:57645 IMAGE:5744362), complete cds. JD046835 - Sequence 27859 from Patent EP1572962. AK225741 - Homo sapiens mRNA for BCL2-associated athanogene 5 isoform a variant, clone: TST06317. JD353581 - Sequence 334605 from Patent EP1572962. JD515684 - Sequence 496708 from Patent EP1572962. JD147107 - Sequence 128131 from Patent EP1572962. KJ898045 - Synthetic construct Homo sapiens clone ccsbBroadEn_07439 BAG5 gene, encodes complete protein. AB384026 - Synthetic construct DNA, clone: pF1KSDA0873, Homo sapiens BAG5 gene for BAG family molecular chaperone regulator 5, complete cds, without stop codon, in Flexi system. CU690720 - Synthetic construct Homo sapiens gateway clone IMAGE:100021382 5' read BAG5 mRNA. AB362576 - Homo sapiens BAG5 mRNA for BCL2-associated athanogene 5, partial cds, splicing variant 1.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9UL15 (Reactome details) participates in the following event(s):
R-HSA-5252079 HSP110s exchange ATP for ADP on HSP70s:ADP R-HSA-3371453 Regulation of HSF1-mediated heat shock response R-HSA-3371556 Cellular response to heat stress R-HSA-2262752 Cellular responses to stress R-HSA-8953897 Cellular responses to external stimuli
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
