ID:B3GA1_HUMAN DESCRIPTION: RecName: Full=Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1; EC=2.4.1.135; AltName: Full=Beta-1,3-glucuronyltransferase 1; AltName: Full=Glucuronosyltransferase P; Short=GlcAT-P; AltName: Full=UDP-GlcUA:glycoprotein beta-1,3-glucuronyltransferase; Short=GlcUAT-P; FUNCTION: Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on glycoproteins. Can also play a role in glycosaminoglycan biosynthesis. Substrates include asialo- orosomucoid (ASOR), asialo-fetuin, and asialo-neural cell adhesion molecule. Requires sphingomyelin for activity: stearoyl- sphingomyelin was the most effective, followed by palmitoyl- sphingomyelin and lignoceroyl-sphingomyelin. Activity was demonstrated only for sphingomyelin with a saturated fatty acid and not for that with an unsaturated fatty acid, regardless of the length of the acyl group (By similarity). CATALYTIC ACTIVITY: UDP-glucuronate + 3-beta-D-galactosyl-4-beta- D-galactosyl-O-beta-D-xylosylprotein = UDP + 3-beta-D- glucuronosyl-3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D- xylosylprotein. COFACTOR: Manganese. PATHWAY: Protein modification; protein glycosylation. SUBUNIT: Homodimer (Potential). SUBCELLULAR LOCATION: Golgi apparatus membrane; Single-pass type II membrane protein. TISSUE SPECIFICITY: Mainly expressed in the brain. SIMILARITY: Belongs to the glycosyltransferase 43 family. WEB RESOURCE: Name=GGDB; Note=GlycoGene database; URL="http://riodb.ibase.aist.go.jp/rcmg/ggdb/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9P2W7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0008499 UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity GO:0016740 transferase activity GO:0046872 metal ion binding
Biological Process: GO:0005975 carbohydrate metabolic process GO:0006486 protein glycosylation GO:0030203 glycosaminoglycan metabolic process GO:0030204 chondroitin sulfate metabolic process GO:0050650 chondroitin sulfate proteoglycan biosynthetic process
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
