ID:AT2A3_HUMAN DESCRIPTION: RecName: Full=Sarcoplasmic/endoplasmic reticulum calcium ATPase 3; Short=SERCA3; Short=SR Ca(2+)-ATPase 3; EC=3.6.3.8; AltName: Full=Calcium pump 3; FUNCTION: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports calcium ions from the cytosol into the sarcoplasmic/endoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction. CATALYTIC ACTIVITY: ATP + H(2)O + Ca(2+)(Side 1) = ADP + phosphate + Ca(2+)(Side 2). SUBCELLULAR LOCATION: Nucleus membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Sarcoplasmic reticulum membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Found in most tissues. Most abundant in thymus, trachea, salivary gland, spleen, bone marrow, lymph node, peripheral leukocytes, pancreas and colon. Also detected in fetal tissues. Expressed in cell lineages of hematopoietic, epithelial, or embryonic origin and also expressed in several cancer cell lines. SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 81653 - Calcium ATPase, transduction domain A 56784 - HAD-like 81660 - Metal cation-transporting ATPase, ATP-binding domain N 81665 - Calcium ATPase, transmembrane domain M
ModBase Predicted Comparative 3D Structure on Q93084
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006811 ion transport GO:0006816 calcium ion transport GO:0034220 ion transmembrane transport GO:0070588 calcium ion transmembrane transport GO:0099132 ATP hydrolysis coupled cation transmembrane transport GO:1903779 regulation of cardiac conduction
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
