Human Gene ATG2B (ENST00000359933.6_7) from GENCODE V47lift37

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Description: autophagy related 2B (from RefSeq NM_018036.7)
Gencode Transcript: ENST00000359933.6_7
Gencode Gene: ENSG00000066739.12_9
Transcript (Including UTRs)
Position: hg19 chr14:96,745,532-96,829,678 Size: 84,147 Total Exon Count: 42 Strand: -
Coding Region
Position: hg19 chr14:96,752,092-96,829,313 Size: 77,222 Coding Exon Count: 42

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species
GO Annotations	mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr14:96,745,532-96,829,678)			mRNA (may differ from genome)		Protein (2078 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	OMIM	PubMed	UniProtKB
BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: ATG2B_HUMAN DESCRIPTION: RecName: Full=Autophagy-related protein 2 homolog B; SIMILARITY: Belongs to the ATG2 family. SEQUENCE CAUTION: Sequence=BAA91504.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB70872.1; Type=Erroneous termination; Positions=800; Note=Translated as Glu; Sequence=BAC87363.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: ATG2B Diseases sorted by gene-association score: hypertrophy of breast (6)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene C532162 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine D000082 Acetaminophen D016604 Aflatoxin B1 D000393 Air Pollutants D001564 Benzo(a)pyrene D019327 Copper Sulfate D004997 Ethinyl Estradiol D011374 Progesterone D013629 Tamoxifen D013749 Tetrachlorodibenzodioxin more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 12.84 RPKM in Brain - Cerebellar Hemisphere Total median expression: 332.21 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-181.90	365	-0.498	Picture	PostScript	Text
3' UTR	-1817.90	6560	-0.277	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR026849 - ATG2
IPR015412 - Autophagy-rel_C
IPR026854 - VPS13A_N

Pfam Domains:
PF09333 - Autophagy-related protein C terminal domain
PF12624 - N-terminal region of Chorein or VPS13

ModBase Predicted Comparative 3D Structure on Q96BY7


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	Genome Browser	No ortholog
Gene Details	Gene Details		Gene Details	Gene Details
Gene Sorter	Gene Sorter		Gene Sorter	Gene Sorter
	RGD			WormBase
				Protein Sequence
				Alignment

Gene Ontology (GO) Annotations with Structured Vocabulary


	Biological Process: GO:0000045 autophagosome assembly GO:0000422 mitophagy GO:0006914 autophagy GO:0044804 nucleophagy Cellular Component: GO:0000407 pre-autophagosomal structure GO:0005654 nucleoplasm GO:0005811 lipid particle GO:0016020 membrane GO:0019898 extrinsic component of membrane GO:0034045 pre-autophagosomal structure membrane

Descriptions from all associated GenBank mRNAs


	LF209642 - JP 2014500723-A/17145: Polycomb-Associated Non-Coding RNAs. AK123451 - Homo sapiens cDNA FLJ41457 fis, clone BRSTN2013502. LF330354 - JP 2014500723-A/137857: Polycomb-Associated Non-Coding RNAs. LF330355 - JP 2014500723-A/137858: Polycomb-Associated Non-Coding RNAs. AL133095 - Homo sapiens mRNA; cDNA DKFZp434L1028 (from clone DKFZp434L1028). AK001104 - Homo sapiens cDNA FLJ10242 fis, clone HEMBB1000630. AK128275 - Homo sapiens cDNA FLJ46412 fis, clone THYMU3011534. BC015016 - Homo sapiens ATG2 autophagy related 2 homolog B (S. cerevisiae), mRNA (cDNA clone IMAGE:3920437), partial cds. JD327319 - Sequence 308343 from Patent EP1572962. JD146554 - Sequence 127578 from Patent EP1572962. JD109839 - Sequence 90863 from Patent EP1572962. JD501754 - Sequence 482778 from Patent EP1572962. JD082123 - Sequence 63147 from Patent EP1572962. JD330738 - Sequence 311762 from Patent EP1572962. JD302901 - Sequence 283925 from Patent EP1572962. JD432988 - Sequence 414012 from Patent EP1572962. JD490073 - Sequence 471097 from Patent EP1572962. JD056086 - Sequence 37110 from Patent EP1572962. JD341578 - Sequence 322602 from Patent EP1572962. JD359964 - Sequence 340988 from Patent EP1572962. JD562740 - Sequence 543764 from Patent EP1572962. JD444172 - Sequence 425196 from Patent EP1572962. JD237241 - Sequence 218265 from Patent EP1572962. KJ902762 - Synthetic construct Homo sapiens clone ccsbBroadEn_12156 ATG2B gene, encodes complete protein. AK302641 - Homo sapiens cDNA FLJ58344 complete cds. LF330361 - JP 2014500723-A/137864: Polycomb-Associated Non-Coding RNAs. CU677169 - Synthetic construct Homo sapiens gateway clone IMAGE:100017466 5' read ATG2B mRNA. LF330364 - JP 2014500723-A/137867: Polycomb-Associated Non-Coding RNAs. JD246068 - Sequence 227092 from Patent EP1572962. JD545789 - Sequence 526813 from Patent EP1572962. JD400556 - Sequence 381580 from Patent EP1572962. LF330366 - JP 2014500723-A/137869: Polycomb-Associated Non-Coding RNAs. BC015851 - Homo sapiens, clone IMAGE:4657824, mRNA. AK055200 - Homo sapiens cDNA FLJ30638 fis, clone CTONG2002721, weakly similar to VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13. JD025157 - Sequence 6181 from Patent EP1572962. JD020484 - Sequence 1508 from Patent EP1572962. JD032541 - Sequence 13565 from Patent EP1572962. JD029173 - Sequence 10197 from Patent EP1572962. LF330373 - JP 2014500723-A/137876: Polycomb-Associated Non-Coding RNAs. LF330374 - JP 2014500723-A/137877: Polycomb-Associated Non-Coding RNAs. MA565931 - JP 2018138019-A/137857: Polycomb-Associated Non-Coding RNAs. MA565932 - JP 2018138019-A/137858: Polycomb-Associated Non-Coding RNAs. MA565938 - JP 2018138019-A/137864: Polycomb-Associated Non-Coding RNAs. MA565941 - JP 2018138019-A/137867: Polycomb-Associated Non-Coding RNAs. MA565943 - JP 2018138019-A/137869: Polycomb-Associated Non-Coding RNAs. MA565950 - JP 2018138019-A/137876: Polycomb-Associated Non-Coding RNAs. MA565951 - JP 2018138019-A/137877: Polycomb-Associated Non-Coding RNAs. MA445219 - JP 2018138019-A/17145: Polycomb-Associated Non-Coding RNAs.

Other Names for This Gene


	Alternate Gene Symbols: ATG2B , ATG2B_HUMAN, C14orf103 , ENST00000359933.1, ENST00000359933.2, ENST00000359933.3, ENST00000359933.4, ENST00000359933.5, NM_018036, Q6ZRE7, Q96BY7, Q96DQ3, Q9NW80, uc318bhk.1, uc318bhk.2 UCSC ID: ENST00000359933.6_7 RefSeq Accession: NM_018036.7 Protein: Q96BY7 (aka ATG2B_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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