Human Gene ARPC5 (ENST00000359856.11_8) from GENCODE V47lift37

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Description: actin related protein 2/3 complex subunit 5, transcript variant 1 (from RefSeq NM_005717.4)
Gencode Transcript: ENST00000359856.11_8
Gencode Gene: ENSG00000162704.16_11
Transcript (Including UTRs)
Position: hg19 chr1:183,589,981-183,604,918 Size: 14,938 Total Exon Count: 4 Strand: -
Coding Region
Position: hg19 chr1:183,596,667-183,604,794 Size: 8,128 Coding Exon Count: 4

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr1:183,589,981-183,604,918)			mRNA (may differ from genome)		Protein (151 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	Reactome	UniProtKB
Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: ARPC5_HUMAN DESCRIPTION: RecName: Full=Actin-related protein 2/3 complex subunit 5; AltName: Full=Arp2/3 complex 16 kDa subunit; Short=p16-ARC; FUNCTION: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. SUBUNIT: Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cell projection. SIMILARITY: Belongs to the ARPC5 family.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D001564 Benzo(a)pyrene D004997 Ethinyl Estradiol D013749 Tetrachlorodibenzodioxin D014635 Valproic Acid C017947 sodium arsenite D000082 Acetaminophen D016604 Aflatoxin B1 D001205 Ascorbic Acid D019327 Copper Sulfate D016572 Cyclosporine more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 109.48 RPKM in Whole Blood Total median expression: 1847.00 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-41.70	124	-0.336	Picture	PostScript	Text
3' UTR	-1708.40	6686	-0.256	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR006789 - ARP2/3_p16_Arc

Pfam Domains:
PF04699 - ARP2/3 complex 16 kDa subunit (p16-Arc)

SCOP Domains:
69103 - Arp2/3 complex 16 kDa subunit ARPC5

ModBase Predicted Comparative 3D Structure on O15511


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	Genome Browser	No ortholog
Gene Details	Gene Details		Gene Details	Gene Details
Gene Sorter	Gene Sorter		Gene Sorter	Gene Sorter
	RGD	Ensembl		WormBase
				Protein Sequence
				Alignment

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0003779 actin binding GO:0005200 structural constituent of cytoskeleton GO:0005515 protein binding GO:0051015 actin filament binding Biological Process: GO:0014909 smooth muscle cell migration GO:0016477 cell migration GO:0021769 orbitofrontal cortex development GO:0030011 maintenance of cell polarity GO:0030036 actin cytoskeleton organization GO:0030833 regulation of actin filament polymerization GO:0034314 Arp2/3 complex-mediated actin nucleation GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis GO:0043312 neutrophil degranulation GO:0048013 ephrin receptor signaling pathway GO:0051639 actin filament network formation GO:0061024 membrane organization GO:0097581 lamellipodium organization Cellular Component: GO:0005576 extracellular region GO:0005737 cytoplasm GO:0005768 endosome GO:0005829 cytosol GO:0005856 cytoskeleton GO:0005885 Arp2/3 protein complex GO:0005925 focal adhesion GO:0015629 actin cytoskeleton GO:0030027 lamellipodium GO:0030426 growth cone GO:0034774 secretory granule lumen GO:0042995 cell projection GO:0043005 neuron projection GO:0070062 extracellular exosome GO:1904813 ficolin-1-rich granule lumen

Descriptions from all associated GenBank mRNAs


	DQ579563 - Homo sapiens piRNA piR-47675, complete sequence. JD476667 - Sequence 457691 from Patent EP1572962. JD256510 - Sequence 237534 from Patent EP1572962. JD414693 - Sequence 395717 from Patent EP1572962. JD567028 - Sequence 548052 from Patent EP1572962. JD466377 - Sequence 447401 from Patent EP1572962. JD308251 - Sequence 289275 from Patent EP1572962. LF205392 - JP 2014500723-A/12895: Polycomb-Associated Non-Coding RNAs. AK095424 - Homo sapiens cDNA FLJ38105 fis, clone D3OST2001328, highly similar to Actin-related protein 2/3 complex subunit 5. AF006088 - Homo sapiens Arp2/3 protein complex subunit p16-Arc (ARC16) mRNA, complete cds. LF209498 - JP 2014500723-A/17001: Polycomb-Associated Non-Coding RNAs. AK129598 - Homo sapiens cDNA FLJ26087 fis, clone RCT05949, highly similar to ARP2/3 complex 16 kDa subunit. JD080931 - Sequence 61955 from Patent EP1572962. JD214715 - Sequence 195739 from Patent EP1572962. BC057237 - Homo sapiens actin related protein 2/3 complex, subunit 5, 16kDa, mRNA (cDNA clone MGC:62039 IMAGE:3931697), complete cds. JD494400 - Sequence 475424 from Patent EP1572962. JD088394 - Sequence 69418 from Patent EP1572962. LF329023 - JP 2014500723-A/136526: Polycomb-Associated Non-Coding RNAs. LF319962 - JP 2014500723-A/127465: Polycomb-Associated Non-Coding RNAs. JD184485 - Sequence 165509 from Patent EP1572962. JD066937 - Sequence 47961 from Patent EP1572962. JD504083 - Sequence 485107 from Patent EP1572962. JD093764 - Sequence 74788 from Patent EP1572962. JD348837 - Sequence 329861 from Patent EP1572962. JD544739 - Sequence 525763 from Patent EP1572962. JD360764 - Sequence 341788 from Patent EP1572962. JD559513 - Sequence 540537 from Patent EP1572962. JD037541 - Sequence 18565 from Patent EP1572962. AF017807 - Homo sapiens Arp2/3 complex 16kDa subunit (ARC16) mRNA, complete cds. HQ447728 - Synthetic construct Homo sapiens clone IMAGE:100071059; CCSB013300_01 actin related protein 2/3 complex, subunit 5, 16kDa (ARPC5) gene, encodes complete protein. KJ902060 - Synthetic construct Homo sapiens clone ccsbBroadEn_11454 ARPC5 gene, encodes complete protein. BC152789 - Synthetic construct Homo sapiens clone IMAGE:100015994, MGC:184188 actin related protein 2/3 complex, subunit 5, 16kDa (ARPC5) mRNA, encodes complete protein. AB528796 - Synthetic construct DNA, clone: pF1KE0262, Homo sapiens ARPC5 gene for actin related protein 2/3 complex, subunit 5, 16kDa, without stop codon, in Flexi system. BC034231 - Homo sapiens cDNA clone IMAGE:5272633, with apparent retained intron. CU691198 - Synthetic construct Homo sapiens gateway clone IMAGE:100022040 5' read ARPC5 mRNA. LF319961 - JP 2014500723-A/127464: Polycomb-Associated Non-Coding RNAs. LF329024 - JP 2014500723-A/136527: Polycomb-Associated Non-Coding RNAs. BC071857 - Homo sapiens actin related protein 2/3 complex, subunit 5, 16kDa, mRNA (cDNA clone MGC:88523 IMAGE:5922521), complete cds. LF319958 - JP 2014500723-A/127461: Polycomb-Associated Non-Coding RNAs. LF319957 - JP 2014500723-A/127460: Polycomb-Associated Non-Coding RNAs. LF329025 - JP 2014500723-A/136528: Polycomb-Associated Non-Coding RNAs. LF319956 - JP 2014500723-A/127459: Polycomb-Associated Non-Coding RNAs. JD409473 - Sequence 390497 from Patent EP1572962. MA564600 - JP 2018138019-A/136526: Polycomb-Associated Non-Coding RNAs. MA564601 - JP 2018138019-A/136527: Polycomb-Associated Non-Coding RNAs. MA564602 - JP 2018138019-A/136528: Polycomb-Associated Non-Coding RNAs. MA440969 - JP 2018138019-A/12895: Polycomb-Associated Non-Coding RNAs. MA445075 - JP 2018138019-A/17001: Polycomb-Associated Non-Coding RNAs. MA555539 - JP 2018138019-A/127465: Polycomb-Associated Non-Coding RNAs. MA555538 - JP 2018138019-A/127464: Polycomb-Associated Non-Coding RNAs. MA555535 - JP 2018138019-A/127461: Polycomb-Associated Non-Coding RNAs. MA555534 - JP 2018138019-A/127460: Polycomb-Associated Non-Coding RNAs. MA555533 - JP 2018138019-A/127459: Polycomb-Associated Non-Coding RNAs.

Biochemical and Signaling Pathways


	Reactome (by CSHL, EBI, and GO) Protein O15511 (Reactome details) participates in the following event(s): R-HSA-442592 WASPs or WAVEs activate the ARP2/3 complex R-HSA-3928595 N-WASP binds ARP2/3 and G-actin R-HSA-8868230 SNX9 recruits components of the actin polymerizing machinery R-HSA-6800434 Exocytosis of ficolin-rich granule lumen proteins R-HSA-6798748 Exocytosis of secretory granule lumen proteins R-HSA-2029466 Attachment of preexisting mother filament and initiation of branching R-HSA-1861595 Extension of pseudopodia by myosin-X in a PI3K dependent manner R-HSA-2197690 Detachment of WASP/WAVE R-HSA-8868236 BAR domain proteins recruit dynamin R-HSA-8871194 RAB5 and GAPVD1 bind AP-2 R-HSA-8868658 HSPA8-mediated ATP hydrolysis promotes vesicle uncoating R-HSA-8868659 Clathrin recruits auxilins to the clathrin-coated vesicle R-HSA-8868661 Dynamin-mediated GTP hydrolysis promotes vesicle scission R-HSA-8868660 Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle R-HSA-8868648 SYNJ hydrolyze PI(4,5)P2 to PI(4)P R-HSA-8868651 Endophilins recruit synaptojanins to the clathrin-coated pit R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation R-HSA-5663213 RHO GTPases Activate WASPs and WAVEs R-HSA-3928662 EPHB-mediated forward signaling R-HSA-8856828 Clathrin-mediated endocytosis R-HSA-6798695 Neutrophil degranulation R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-195258 RHO GTPase Effectors R-HSA-2682334 EPH-Ephrin signaling R-HSA-199991 Membrane Trafficking R-HSA-168249 Innate Immune System R-HSA-194315 Signaling by Rho GTPases R-HSA-422475 Axon guidance R-HSA-5653656 Vesicle-mediated transport R-HSA-168256 Immune System R-HSA-162582 Signal Transduction R-HSA-1266738 Developmental Biology

Other Names for This Gene


	Alternate Gene Symbols: A6NEC4, ARC16, ARPC5_HUMAN, ENST00000359856.1, ENST00000359856.10, ENST00000359856.2, ENST00000359856.3, ENST00000359856.4, ENST00000359856.5, ENST00000359856.6, ENST00000359856.7, ENST00000359856.8, ENST00000359856.9, NM_005717, O15511, Q6PG42, uc318bge.1, uc318bge.2 UCSC ID: ENST00000359856.11_8 RefSeq Accession: NM_005717.4 Protein: O15511 (aka ARPC5_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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