ID:RHG06_HUMAN DESCRIPTION: RecName: Full=Rho GTPase-activating protein 6; AltName: Full=Rho-type GTPase-activating protein 6; AltName: Full=Rho-type GTPase-activating protein RhoGAPX-1; FUNCTION: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Could regulate the interactions of signaling molecules with the actin cytoskeleton. Promotes continuous elongation of cytoplasmic processes during cell motility and simultaneous retraction of the cell body changing the cell morphology. SUBCELLULAR LOCATION: Cytoplasm. TISSUE SPECIFICITY: Highly expressed in kidney, heart and skeletal muscle followed by retina, lymphoblast, placenta, lung, brain, pancreas and liver. MISCELLANEOUS: ARHGAP6 gene undergoes X inactivation. SIMILARITY: Contains 1 Rho-GAP domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O43182
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0007015 actin filament organization GO:0007165 signal transduction GO:0007202 activation of phospholipase C activity GO:0007266 Rho protein signal transduction GO:0009967 positive regulation of signal transduction GO:0010518 positive regulation of phospholipase activity GO:0030041 actin filament polymerization GO:0043087 regulation of GTPase activity GO:0043547 positive regulation of GTPase activity GO:0048041 focal adhesion assembly GO:0051056 regulation of small GTPase mediated signal transduction GO:0051497 negative regulation of stress fiber assembly GO:0051895 negative regulation of focal adhesion assembly
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
