Human Gene ARHGAP15 (ENST00000295095.11

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Human Gene ARHGAP15 (ENST00000295095.11_4) from GENCODE V47lift37

Description: Rho GTPase activating protein 15 (from RefSeq NM_018460.4)
Gencode Transcript: ENST00000295095.11_4
Gencode Gene: ENSG00000075884.14_11
Transcript (Including UTRs)
Position: hg19 chr2:143,886,988-144,525,921 Size: 638,934 Total Exon Count: 14 Strand: +
Coding Region
Position: hg19 chr2:143,913,060-144,525,741 Size: 612,682 Coding Exon Count: 13

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr2:143,886,988-144,525,921)			mRNA (may differ from genome)		Protein (475 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	Reactome	UniProtKB
BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: RHG15_HUMAN DESCRIPTION: RecName: Full=Rho GTPase-activating protein 15; AltName: Full=ArhGAP15; AltName: Full=Rho-type GTPase-activating protein 15; FUNCTION: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has activity toward RAC1. Overexpression results in an increase in actin stress fibers and cell contraction. SUBCELLULAR LOCATION: Cytoplasm. Membrane; Peripheral membrane protein. TISSUE SPECIFICITY: Expressed in lung, liver and lymphoid cells. DOMAIN: The PH domain is required for localization to the membrane. SIMILARITY: Contains 1 PH domain. SIMILARITY: Contains 1 Rho-GAP domain. SEQUENCE CAUTION: Sequence=AAF67618.1; Type=Frameshift; Positions=140, 185, 195, 202, 260, 265, 268, 311, 316, 323, 332; Sequence=AAF67633.1; Type=Frameshift; Positions=Several; Sequence=AAF87324.1; Type=Frameshift; Positions=202, 233, 255, 259, 265, 268, 311, 314, 316, 320, 322, 326, 332, 338, 340, 418;

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D001564 Benzo(a)pyrene C532162 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine D000638 Amiodarone D002737 Chloroprene D002794 Choline D004054 Diethylstilbestrol D005492 Folic Acid D005839 Gentamicins D008715 Methionine D013806 Theophylline more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 12.88 RPKM in Whole Blood Total median expression: 65.48 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-9.70	62	-0.156	Picture	PostScript	Text
3' UTR	-26.80	180	-0.149	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR011993 - PH_like_dom
IPR001849 - Pleckstrin_homology
IPR015767 - Rho_GTPase_activating
IPR008936 - Rho_GTPase_activation_prot
IPR000198 - RhoGAP_dom

Pfam Domains:
PF00169 - PH domain
PF00620 - RhoGAP domain

SCOP Domains:
48350 - GTPase activation domain, GAP
48371 - ARM repeat
103657 - BAR/IMD domain-like
50729 - PH domain-like

Protein Data Bank (PDB) 3-D Structure
MuPIT help

3BYI - X-ray MuPIT

ModBase Predicted Comparative 3D Structure on Q53QZ3


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD	Ensembl

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0005096 GTPase activator activity Biological Process: GO:0007165 signal transduction GO:0008360 regulation of cell shape GO:0043547 positive regulation of GTPase activity GO:0051056 regulation of small GTPase mediated signal transduction Cellular Component: GO:0005737 cytoplasm GO:0005829 cytosol GO:0016020 membrane

Descriptions from all associated GenBank mRNAs


	BC029346 - Homo sapiens Rho GTPase activating protein 15, mRNA (cDNA clone IMAGE:4104470), ** WARNING: chimeric clone **. AK308219 - Homo sapiens cDNA, FLJ98167. AF212222 - Homo sapiens BM024 mRNA, complete cds. AF217507 - Homo sapiens uncharacterized bone marrow protein BM030 mRNA, complete cds. AF217522 - Homo sapiens uncharacterized bone marrow protein BM046 mRNA, complete cds. AY219338 - Homo sapiens ARHGAP15 mRNA, complete cds. AK226014 - Homo sapiens mRNA for ARHGAP15 variant, clone: FCC107C12. AK303490 - Homo sapiens cDNA FLJ56761 complete cds, highly similar to Homo sapiens Rho GTPase activating protein 15 (ARHGAP15), mRNA. BC016701 - Homo sapiens Rho GTPase activating protein 15, mRNA (cDNA clone MGC:22738 IMAGE:4108644), complete cds. BC038976 - Homo sapiens Rho GTPase activating protein 15, mRNA (cDNA clone MGC:47639 IMAGE:5553184), complete cds. CU677683 - Synthetic construct Homo sapiens gateway clone IMAGE:100022329 5' read ARHGAP15 mRNA. KJ899203 - Synthetic construct Homo sapiens clone ccsbBroadEn_08597 ARHGAP15 gene, encodes complete protein. JD188591 - Sequence 169615 from Patent EP1572962.

Biochemical and Signaling Pathways


	Reactome (by CSHL, EBI, and GO) Protein Q53QZ3 (Reactome details) participates in the following event(s): R-HSA-194922 GAPs inactivate Rho GTPase:GTP by hydrolysis R-HSA-194840 Rho GTPase cycle R-HSA-194315 Signaling by Rho GTPases R-HSA-162582 Signal Transduction

Other Names for This Gene


	Alternate Gene Symbols: BM-024, BM-030, BM-046, ENST00000295095.1, ENST00000295095.10, ENST00000295095.2, ENST00000295095.3, ENST00000295095.4, ENST00000295095.5, ENST00000295095.6, ENST00000295095.7, ENST00000295095.8, ENST00000295095.9, NM_018460, Q53QZ3, Q53R36, Q53RD7, Q53RT6, Q53SX9, Q584N9, Q6PJE6, Q86WP1, Q8IXX1, Q9NRL8, Q9NZ77, Q9NZ91, RHG15_HUMAN, uc317ljt.1, uc317ljt.2 UCSC ID: ENST00000295095.11_4 RefSeq Accession: NM_018460.4 Protein: Q53QZ3 (aka RHG15_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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