ID:AQP7_HUMAN DESCRIPTION: RecName: Full=Aquaporin-7; Short=AQP-7; AltName: Full=Aquaglyceroporin-7; AltName: Full=Aquaporin adipose; Short=AQPap; AltName: Full=Aquaporin-7-like; FUNCTION: Forms a channel for water and glycerol. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. DOMAIN: Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro/Ala-Ala/Ser (NPA). POLYMORPHISM: Genetic variations in AQP7 are responsible for changes in glycerol release during exercise and define the glycerol quantitative trait locus (GLYCQTL) [MIM:614411]. SIMILARITY: Belongs to the MIP/aquaporin (TC 1.A.8) family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O14520
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Protein O14520 (Reactome details) participates in the following event(s):
R-HSA-432074 Aquaporin-7 passively transports glycerol out of cell R-HSA-507869 Aquaporins passively transport glycerol into cells R-HSA-507871 Aquaporins passively transport glycerol out of cells R-HSA-507868 Aquaporins passively transport water into cells R-HSA-507870 Aquaporins passively transport water out of cells R-HSA-432030 Transport of glycerol from adipocytes to the liver by Aquaporins R-HSA-432047 Passive transport by Aquaporins R-HSA-445717 Aquaporin-mediated transport R-HSA-382551 Transport of small molecules
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
