Human Gene APCS (ENST00000255040.3_4) from GENCODE V47lift37

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Description: amyloid P component, serum (from RefSeq NM_001639.4)
Gencode Transcript: ENST00000255040.3_4
Gencode Gene: ENSG00000132703.4_7
Transcript (Including UTRs)
Position: hg19 chr1:159,557,616-159,558,655 Size: 1,040 Total Exon Count: 2 Strand: +
Coding Region
Position: hg19 chr1:159,557,712-159,558,498 Size: 787 Coding Exon Count: 2

Page Index	Sequence and Links	Primers	MalaCards	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Other Species	mRNA Descriptions	Other Names
Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr1:159,557,616-159,558,655)			mRNA (may differ from genome)		Protein (223 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	OMIM	PubMed	UniProtKB
Wikipedia	BioGrid CRISPR DB

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: APCS Diseases sorted by gene-association score: candidiasis (4), carotenemia (2), candida glabrata (2), splenic artery aneurysm (1), shwartzman phenomenon (1)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D016604 Aflatoxin B1 D001564 Benzo(a)pyrene D002994 Clofibrate D008070 Lipopolysaccharides D013749 Tetrachlorodibenzodioxin C023036 perfluorooctanoic acid C006253 pirinixic acid C049325 1,2-dithiol-3-thione C021183 1,7-dimethylxanthine C023514 2,6-dinitrotoluene C023035 3,4,5,3',4'-pentachlorobiphenyl D000082 Acetaminophen D000638 Amiodarone D000643 Ammonium Chloride D001280 Atrazine D001553 Benzbromarone D002251 Carbon Tetrachloride D002351 Carrageenan D002509 Cephaloridine D002794 Choline D002995 Clofibric Acid D003042 Cocaine D003300 Copper D016572 Cyclosporine D004052 Diethylnitrosamine D004958 Estradiol D005001 Ethionine D005492 Folic Acid D006493 Heparin D007657 Ketone Bodies D008715 Methionine D009151 Mustard Gas D037742 Nanotubes, Carbon D009853 Omeprazole D052638 Particulate Matter D010634 Phenobarbital D011441 Propylthiouracil D022641 Shiga Toxin 2 D013629 Tamoxifen D013853 Thioacetamide D014415 Tunicamycin D019324 beta-Naphthoflavone C005961 bis(tri-n-butyltin)oxide C019304 ciprofibrate C030123 coumarin C056933 fumonisin B1 C056507 gemcitabine C482199 lipopolysaccharide, E coli O55-B5 C037473 nickel hydroxide (II) C042763 olive oil C016030 pantogab C076994 perfluorooctane sulfonic acid C030984 pyrene C032910 triadimefon C081489 valsartan

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 1007.79 RPKM in Liver Total median expression: 1009.92 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-27.40	96	-0.285	Picture	PostScript	Text
3' UTR	-23.60	157	-0.150	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Descriptions from all associated GenBank mRNAs


	BC007039 - Homo sapiens amyloid P component, serum, mRNA (cDNA clone MGC:12419 IMAGE:3935086), complete cds. BC070178 - Homo sapiens amyloid P component, serum, mRNA (cDNA clone IMAGE:4723576), complete cds. X04608 - Human mRNA for serum amyloid P component (SAP). BC007058 - Homo sapiens amyloid P component, serum, mRNA (cDNA clone MGC:12497 IMAGE:3934872), complete cds. FJ460512 - Homo sapiens epididymis secretory sperm binding protein Li 92n (HEL-S-92n) mRNA, complete cds. JD549268 - Sequence 530292 from Patent EP1572962. CU675509 - Synthetic construct Homo sapiens gateway clone IMAGE:100020179 5' read APCS mRNA. AB587585 - Synthetic construct DNA, clone: pF1KB8896, Homo sapiens APCS gene for amyloid P component, serum, without stop codon, in Flexi system. CR450313 - Homo sapiens full open reading frame cDNA clone RZPDo834F071D for gene APCS, amyloid P component, serum; complete cds; without stopcodon. BT006750 - Homo sapiens amyloid P component, serum mRNA, complete cds. KJ896437 - Synthetic construct Homo sapiens clone ccsbBroadEn_05831 APCS gene, encodes complete protein. M10944 - Human serum amyloid P component (SAP) mRNA, complete cds. JD019594 - Sequence 618 from Patent EP1572962. JD032852 - Sequence 13876 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: APCS , ENST00000255040.1, ENST00000255040.2, hCG_39427 , HEL-S-92n , NM_001639, uc317fqt.1, uc317fqt.2, V9HWP0, V9HWP0_HUMAN UCSC ID: ENST00000255040.3_4 RefSeq Accession: NM_001639.4

Gene Model Information


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Methods, Credits, and Use Restrictions


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