Human Gene ANXA3 (ENST00000264908.11_4) from GENCODE V47lift37
  Description: annexin A3 (from RefSeq NM_005139.3)
Gencode Transcript: ENST00000264908.11_4
Gencode Gene: ENSG00000138772.13_10
Transcript (Including UTRs)
   Position: hg19 chr4:79,472,924-79,531,601 Size: 58,678 Total Exon Count: 13 Strand: +
Coding Region
   Position: hg19 chr4:79,475,628-79,531,269 Size: 55,642 Coding Exon Count: 12 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr4:79,472,924-79,531,601)mRNA (may differ from genome)Protein (323 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ANXA3_HUMAN
DESCRIPTION: RecName: Full=Annexin A3; AltName: Full=35-alpha calcimedin; AltName: Full=Annexin III; AltName: Full=Annexin-3; AltName: Full=Inositol 1,2-cyclic phosphate 2-phosphohydrolase; AltName: Full=Lipocortin III; AltName: Full=Placental anticoagulant protein III; Short=PAP-III;
FUNCTION: Inhibitor of phospholipase A2, also possesses anti- coagulant properties. Also cleaves the cyclic bond of inositol 1,2-cyclic phosphate to form inositol 1-phosphate.
DOMAIN: A pair of annexin repeats may form one binding site for calcium and phospholipid.
SIMILARITY: Belongs to the annexin family.
SIMILARITY: Contains 4 annexin repeats.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 60.00 RPKM in Whole Blood
Total median expression: 591.87 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -36.40128-0.284 Picture PostScript Text
3' UTR -51.50332-0.155 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001464 - Annexin
IPR018502 - Annexin_repeat
IPR018252 - Annexin_repeat_CS
IPR002390 - AnnexinIII

Pfam Domains:
PF00191 - Annexin

SCOP Domains:
47874 - Annexin

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1AII - X-ray MuPIT 1AXN - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P12429
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004859 phospholipase inhibitor activity
GO:0005509 calcium ion binding
GO:0005544 calcium-dependent phospholipid binding
GO:0019834 phospholipase A2 inhibitor activity
GO:0048306 calcium-dependent protein binding

Biological Process:
GO:0006909 phagocytosis
GO:0010595 positive regulation of endothelial cell migration
GO:0021766 hippocampus development
GO:0031100 animal organ regeneration
GO:0042742 defense response to bacterium
GO:0043086 negative regulation of catalytic activity
GO:0043312 neutrophil degranulation
GO:0045766 positive regulation of angiogenesis
GO:0051054 positive regulation of DNA metabolic process
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051384 response to glucocorticoid
GO:0070848 response to growth factor

Cellular Component:
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030424 axon
GO:0030425 dendrite
GO:0030670 phagocytic vesicle membrane
GO:0042581 specific granule
GO:0043025 neuronal cell body
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  LP895485 - Sequence 349 from Patent EP3253886.
BC000871 - Homo sapiens annexin A3, mRNA (cDNA clone MGC:5043 IMAGE:3460409), complete cds.
AK313945 - Homo sapiens cDNA, FLJ94587, Homo sapiens annexin A3 (ANXA3), mRNA.
M20560 - Human lipocortin-III mRNA, complete cds.
M63310 - Human 1,2-cyclic-inositol-phosphate phosphodiesterase (ANX3) mRNA, complete cds.
AB590684 - Synthetic construct DNA, clone: pFN21AE1807, Homo sapiens ANXA3 gene for annexin A3, without stop codon, in Flexi system.
HQ448145 - Synthetic construct Homo sapiens clone IMAGE:100071530; CCSB002735_01 annexin A3 (ANXA3) gene, encodes complete protein.
CR407648 - Homo sapiens full open reading frame cDNA clone RZPDo834G042D for gene ANXA3, annexin A3 complete cds, without stopcodon.
AB209868 - Homo sapiens mRNA for annexin A3 variant protein.
JD303841 - Sequence 284865 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ANX3, ANXA3_HUMAN, B2R9W6, ENST00000264908.1, ENST00000264908.10, ENST00000264908.2, ENST00000264908.3, ENST00000264908.4, ENST00000264908.5, ENST00000264908.6, ENST00000264908.7, ENST00000264908.8, ENST00000264908.9, NM_005139, P12429, Q6LET2, uc317hwo.1, uc317hwo.2
UCSC ID: ENST00000264908.11_4
RefSeq Accession: NM_005139.3
Protein: P12429 (aka ANXA3_HUMAN or ANX3_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.