Human Gene ANXA1 (ENST00000257497.11_4) from GENCODE V47lift37
  Description: annexin A1 (from RefSeq NM_000700.3)
Gencode Transcript: ENST00000257497.11_4
Gencode Gene: ENSG00000135046.15_9
Transcript (Including UTRs)
   Position: hg19 chr9:75,766,781-75,785,309 Size: 18,529 Total Exon Count: 13 Strand: +
Coding Region
   Position: hg19 chr9:75,773,452-75,785,023 Size: 11,572 Coding Exon Count: 12 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr9:75,766,781-75,785,309)mRNA (may differ from genome)Protein (346 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCHuman Cortex Gene ExpressionMalacardsMGIOMIMPubMed
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: Q5TZZ9_HUMAN
DESCRIPTION: RecName: Full=Annexin;
DOMAIN: A pair of annexin repeats may form one binding site for calcium and phospholipid (By similarity).
SIMILARITY: Belongs to the annexin family.
SIMILARITY: Contains 4 annexin repeats.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: ANXA1
Diseases sorted by gene-association score: hairy cell leukemia (7), brain edema (5), rheumatoid arthritis (3), lung cancer susceptibility 3 (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 1575.88 RPKM in Esophagus - Mucosa
Total median expression: 3748.44 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -16.2074-0.219 Picture PostScript Text
3' UTR -39.00286-0.136 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001464 - Annexin
IPR018502 - Annexin_repeat
IPR018252 - Annexin_repeat_CS
IPR002388 - AnnexinI

Pfam Domains:
PF00191 - Annexin

SCOP Domains:
109998 - Triger factor/SurA peptide-binding domain-like
46934 - UBA-like
47874 - Annexin
52467 - DHS-like NAD/FAD-binding domain
63411 - LuxS/MPP-like metallohydrolase

ModBase Predicted Comparative 3D Structure on Q5TZZ9
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003697 single-stranded DNA binding
GO:0003727 single-stranded RNA binding
GO:0004859 phospholipase inhibitor activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005543 phospholipid binding
GO:0005544 calcium-dependent phospholipid binding
GO:0019834 phospholipase A2 inhibitor activity
GO:0033676 double-stranded DNA-dependent ATPase activity
GO:0042803 protein homodimerization activity
GO:1990814 DNA/DNA annealing activity

Biological Process:
GO:0001780 neutrophil homeostasis
GO:0002685 regulation of leukocyte migration
GO:0006909 phagocytosis
GO:0006954 inflammatory response
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0009725 response to hormone
GO:0010165 response to X-ray
GO:0014070 response to organic cyclic compound
GO:0014839 myoblast migration involved in skeletal muscle regeneration
GO:0030073 insulin secretion
GO:0030850 prostate gland development
GO:0031018 endocrine pancreas development
GO:0031394 positive regulation of prostaglandin biosynthetic process
GO:0031960 response to corticosteroid
GO:0032355 response to estradiol
GO:0032508 DNA duplex unwinding
GO:0032652 regulation of interleukin-1 production
GO:0033031 positive regulation of neutrophil apoptotic process
GO:0042063 gliogenesis
GO:0042127 regulation of cell proliferation
GO:0042493 response to drug
GO:0043065 positive regulation of apoptotic process
GO:0043434 response to peptide hormone
GO:0044849 estrous cycle
GO:0046632 alpha-beta T cell differentiation
GO:0050482 arachidonic acid secretion
GO:0050709 negative regulation of protein secretion
GO:0050727 regulation of inflammatory response
GO:0051384 response to glucocorticoid
GO:0070301 cellular response to hydrogen peroxide
GO:0070365 hepatocyte differentiation
GO:0070459 prolactin secretion
GO:0070555 response to interleukin-1
GO:0071385 cellular response to glucocorticoid stimulus
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle
GO:1900138 negative regulation of phospholipase A2 activity

Cellular Component:
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016324 apical plasma membrane
GO:0016328 lateral plasma membrane
GO:0031514 motile cilium
GO:0031966 mitochondrial membrane
GO:0032991 macromolecular complex
GO:0042383 sarcolemma
GO:0042629 mast cell granule


-  Descriptions from all associated GenBank mRNAs
  AK311684 - Homo sapiens cDNA, FLJ18726.
AK296808 - Homo sapiens cDNA FLJ51887 complete cds, highly similar to Annexin A1.
BC035993 - Homo sapiens annexin A1, mRNA (cDNA clone MGC:32774 IMAGE:4662939), complete cds.
X05908 - Homo sapiens mRNA for lipocortin.
BC001275 - Homo sapiens annexin A1, mRNA (cDNA clone MGC:5095 IMAGE:3459615), complete cds.
JD298475 - Sequence 279499 from Patent EP1572962.
AK074480 - Homo sapiens cDNA FLJ23900 fis, clone LNG15486, highly similar to ANNEXIN I.
KJ896427 - Synthetic construct Homo sapiens clone ccsbBroadEn_05821 ANXA1 gene, encodes complete protein.
KJ896428 - Synthetic construct Homo sapiens clone ccsbBroadEn_05822 ANXA1 gene, encodes complete protein.
CU690250 - Synthetic construct Homo sapiens gateway clone IMAGE:100022209 5' read ANXA1 mRNA.
CU674640 - Synthetic construct Homo sapiens gateway clone IMAGE:100019041 5' read ANXA1 mRNA.
AB451401 - Homo sapiens ANXA1 mRNA for annexin I, partial cds, clone: FLJ08104AAAF.
AB529026 - Synthetic construct DNA, clone: pF1KB3392, Homo sapiens ANXA1 gene for annexin A1, without stop codon, in Flexi system.
CR407684 - Homo sapiens full open reading frame cDNA clone RZPDo834D053D for gene ANXA1, annexin A1 complete cds, without stopcodon.
DQ894338 - Synthetic construct Homo sapiens clone IMAGE:100008798; FLH169842.01L; RZPDo839G1095D annexin A1 (ANXA1) gene, encodes complete protein.
BT019896 - Homo sapiens annexin A1 mRNA, complete cds.
BT019916 - Homo sapiens annexin A1 mRNA, complete cds.
BT019917 - Homo sapiens annexin A1 mRNA, complete cds.
DQ891173 - Synthetic construct clone IMAGE:100003803; FLH169846.01X; RZPDo839G1096D annexin A1 (ANXA1) gene, encodes complete protein.
AB451274 - Homo sapiens ANXA1 mRNA for annexin I, complete cds, clone: FLJ08104AAAN.
GQ891377 - Homo sapiens clone HEL-S-172n epididymis secretory sperm binding protein mRNA, complete cds.
E01979 - DNA encoding new human lipocortin.
BC018683 - Homo sapiens annexin A1, mRNA (cDNA clone IMAGE:4692693), with apparent retained intron.
BC034157 - Homo sapiens annexin A1, mRNA (cDNA clone IMAGE:4733055), complete cds.
JD299983 - Sequence 281007 from Patent EP1572962.
JD362953 - Sequence 343977 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_gcrPathway - Corticosteroids and cardioprotection

-  Other Names for This Gene
  Alternate Gene Symbols: ANXA1 , ENST00000257497.1, ENST00000257497.10, ENST00000257497.2, ENST00000257497.3, ENST00000257497.4, ENST00000257497.5, ENST00000257497.6, ENST00000257497.7, ENST00000257497.8, ENST00000257497.9, hCG_17305 , NM_000700, Q5TZZ9, Q5TZZ9_HUMAN, uc317fyf.1, uc317fyf.2
UCSC ID: ENST00000257497.11_4
RefSeq Accession: NM_000700.3
Protein: Q5TZZ9

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.