Human Gene ANKRD18A (ENST00000399703.6_9) from GENCODE V47lift37
  Description: ankyrin repeat domain 18A, transcript variant 2 (from RefSeq NM_147195.4)
Gencode Transcript: ENST00000399703.6_9
Gencode Gene: ENSG00000180071.21_15
Transcript (Including UTRs)
   Position: hg19 chr9:38,571,361-38,620,593 Size: 49,233 Total Exon Count: 16 Strand: -
Coding Region
   Position: hg19 chr9:38,572,042-38,620,282 Size: 48,241 Coding Exon Count: 16 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesmRNA DescriptionsOther Names
Model InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr9:38,571,361-38,620,593)mRNA (may differ from genome)Protein (992 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MGIPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: AN18A_HUMAN
DESCRIPTION: RecName: Full=Ankyrin repeat domain-containing protein 18A;
SIMILARITY: Contains 5 ANK repeats.
SEQUENCE CAUTION: Sequence=AAH56266.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=BAC23111.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 9.63 RPKM in Testis
Total median expression: 35.99 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -125.70311-0.404 Picture PostScript Text
3' UTR -157.10681-0.231 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002110 - Ankyrin_rpt
IPR020683 - Ankyrin_rpt-contain_dom
IPR021885 - DUF3496

Pfam Domains:
PF00023 - Ankyrin repeat
PF12001 - Domain of unknown function (DUF3496)
PF12796 - Ankyrin repeats (3 copies)
PF13637 - Ankyrin repeats (many copies)
PF13857 - Ankyrin repeats (many copies)
PF14915 - CCDC144C protein coiled-coil region

SCOP Domains:
140860 - Pseudo ankyrin repeat-like
48403 - Ankyrin repeat

ModBase Predicted Comparative 3D Structure on Q8IVF6
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Descriptions from all associated GenBank mRNAs
  AK093059 - Homo sapiens cDNA FLJ35740 fis, clone TESTI2004085.
AX747892 - Sequence 1417 from Patent EP1308459.
LP896544 - Sequence 1408 from Patent EP3253886.
BC131497 - Homo sapiens cDNA clone IMAGE:40081082.
AY550933 - Homo sapiens FLJ35740 protein mRNA, complete cds, alternatively spliced.
BC044950 - Homo sapiens mRNA similar to KIAA1074 protein (cDNA clone IMAGE:5403929).
AB095935 - Homo sapiens mRNA for KIAA2015 protein.
JD085506 - Sequence 66530 from Patent EP1572962.
AB385522 - Synthetic construct DNA, clone: pF1KA2015, Homo sapiens ANKRD18A gene for ankyrin repeat domain-containing protein 18A, complete cds, without stop codon, in Flexi system.
KJ900500 - Synthetic construct Homo sapiens clone ccsbBroadEn_09894 ANKRD18A gene, encodes complete protein.
DQ599413 - Homo sapiens piRNA piR-37479, complete sequence.
DQ601426 - Homo sapiens piRNA piR-39492, complete sequence.
DQ599240 - Homo sapiens piRNA piR-37306, complete sequence.
BC056266 - Homo sapiens ankyrin repeat domain 18A, mRNA (cDNA clone IMAGE:6668513), partial cds.
DQ588465 - Homo sapiens piRNA piR-55577, complete sequence.
DQ580187 - Homo sapiens piRNA piR-48299, complete sequence.
JD423845 - Sequence 404869 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A7MD11, A8MVU5, AN18A_HUMAN, ENST00000399703.1, ENST00000399703.2, ENST00000399703.3, ENST00000399703.4, ENST00000399703.5, KIAA2015, NM_147195, Q5SY86, Q7Z468, Q8IVF6, Q8NA88, uc319amk.1, uc319amk.2
UCSC ID: ENST00000399703.6_9
RefSeq Accession: NM_147195.4
Protein: Q8IVF6 (aka AN18A_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.