ID:ANKH1_HUMAN DESCRIPTION: RecName: Full=Ankyrin repeat and KH domain-containing protein 1; AltName: Full=HIV-1 Vpr-binding ankyrin repeat protein; AltName: Full=Multiple ankyrin repeats single KH domain; Short=hMASK; FUNCTION: May play a role as a scaffolding protein that may be associated with the abnormal phenotype of leukemia cells. Isoform 2 may possess an antiapoptotic effect and protect cells during normal cell survival through its regulation of caspases. SUBUNIT: Interacts with PTPN11. Isoform 2 interacts with HIV-1 VPR. INTERACTION: Q9NRI5:DISC1; NbExp=6; IntAct=EBI-1785446, EBI-529989; SUBCELLULAR LOCATION: Cytoplasm. TISSUE SPECIFICITY: Ubiquitous with high expression in cervix, spleen and brain. Expressed in hematopoietic cells with increased expression in leukemia cells. Isoform 2 is highly expressed in spleen with almost no expression in muscle and brain. SIMILARITY: Belongs to the mask family. SIMILARITY: Contains 25 ANK repeats. SIMILARITY: Contains 1 KH domain. SEQUENCE CAUTION: Sequence=BAA91417.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB13958.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 140860 - Pseudo ankyrin repeat-like 52540 - P-loop containing nucleoside triphosphate hydrolases 48403 - Ankyrin repeat 54791 - Eukaryotic type KH-domain (KH-domain type I) 54814 - Prokaryotic type KH domain (KH-domain type II)
ModBase Predicted Comparative 3D Structure on Q8IWZ3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
