ID:ANGL4_HUMAN DESCRIPTION: RecName: Full=Angiopoietin-related protein 4; AltName: Full=Angiopoietin-like protein 4; AltName: Full=Hepatic fibrinogen/angiopoietin-related protein; Short=HFARP; Flags: Precursor; FUNCTION: Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorigenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation (By similarity). SUBUNIT: Homooligomer. The homooligomer undergoes proteolytic processing to release its carboxyl fibrinogen-like domain, which circulates as a monomer. The homooligomer unprocessed form is able to interact with the extracellular matrix (By similarity). INTERACTION: P05556:ITGB1; NbExp=2; IntAct=EBI-2968146, EBI-703066; P18084:ITGB5; NbExp=3; IntAct=EBI-2968146, EBI-1223434; SUBCELLULAR LOCATION: Secreted. Secreted, extracellular space, extracellular matrix (By similarity). Note=The unprocessed form interacts with the extracellular matrix. This may constitute a dynamic reservoir, a regulatory mechanism of the bioavailability of ANGPTL4 (By similarity). TISSUE SPECIFICITY: Expressed at high levels in the placenta, heart, liver, muscle, pancreas and lung but expressed poorly in the brain and kidney. PTM: N-glycosylated. SIMILARITY: Contains 1 fibrinogen C-terminal domain. SEQUENCE CAUTION: Sequence=AAQ88642.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9BY76
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004857 enzyme inhibitor activity GO:0005515 protein binding GO:0042802 identical protein binding
Biological Process: GO:0001525 angiogenesis GO:0001666 response to hypoxia GO:0007275 multicellular organism development GO:0019216 regulation of lipid metabolic process GO:0030154 cell differentiation GO:0043066 negative regulation of apoptotic process GO:0045766 positive regulation of angiogenesis GO:0051005 negative regulation of lipoprotein lipase activity GO:0051260 protein homooligomerization GO:0070328 triglyceride homeostasis GO:2000352 negative regulation of endothelial cell apoptotic process
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
