Human Gene ANGPTL1 (ENST00000234816.7_7) from GENCODE V47lift37

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Description: angiopoietin like 1, transcript variant 1 (from RefSeq NM_004673.4)
Gencode Transcript: ENST00000234816.7_7
Gencode Gene: ENSG00000116194.13_10
Transcript (Including UTRs)
Position: hg19 chr1:178,818,670-178,840,212 Size: 21,543 Total Exon Count: 6 Strand: -
Coding Region
Position: hg19 chr1:178,820,264-178,834,911 Size: 14,648 Coding Exon Count: 4

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	RNA Structure	Protein Structure	Other Species	GO Annotations	mRNA Descriptions
Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr1:178,818,670-178,840,212)			mRNA (may differ from genome)		Protein (491 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	UniProtKB	Wikipedia
BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: ANGL1_HUMAN DESCRIPTION: RecName: Full=Angiopoietin-related protein 1; AltName: Full=Angiopoietin-3; Short=ANG-3; AltName: Full=Angiopoietin-like protein 1; Flags: Precursor; SUBCELLULAR LOCATION: Secreted. TISSUE SPECIFICITY: Highly expressed in adrenal gland, placenta, thyroid gland, heart, skeletal muscle and small intestine. Weakly expressed in testis, ovary, colon, pancreas, kidney and stomach. SIMILARITY: Contains 1 fibrinogen C-terminal domain.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D001564 Benzo(a)pyrene D015124 8-Bromo Cyclic Adenosine Monophosphate D019327 Copper Sulfate C523799 MRK 003 D013749 Tetrachlorodibenzodioxin C008261 lead acetate C006253 pirinixic acid C116926 rofecoxib C446685 systhane C034028 vanadyl sulfate

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 37.81 RPKM in Fallopian Tube Total median expression: 426.00 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-97.00	473	-0.205	Picture	PostScript	Text
3' UTR	-295.70	1594	-0.186	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR002181 - Fibrinogen_a/b/g_C
IPR014716 - Fibrinogen_a/b/g_C_1
IPR014715 - Fibrinogen_a/b/g_C_2
IPR020837 - Fibrinogen_CS

Pfam Domains:
PF00147 - Fibrinogen beta and gamma chains, C-terminal globular domain

SCOP Domains:
56496 - Fibrinogen C-terminal domain-like

ModBase Predicted Comparative 3D Structure on O95841


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0005102 receptor binding Biological Process: GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway Cellular Component: GO:0005576 extracellular region GO:0005615 extracellular space GO:0070062 extracellular exosome

Descriptions from all associated GenBank mRNAs


	AF086266 - Homo sapiens full length insert cDNA clone ZD43E11. AY358278 - Homo sapiens clone DNA28497 NL5 (UNQ162) mRNA, complete cds. BC047670 - Homo sapiens cDNA clone IMAGE:5754129, containing frame-shift errors. BC050640 - Homo sapiens angiopoietin-like 1, mRNA (cDNA clone MGC:60131 IMAGE:5725751), complete cds. AK300218 - Homo sapiens cDNA FLJ51304 complete cds, highly similar to Angiopoietin-related protein 1 precursor. JD019976 - Sequence 1000 from Patent EP1572962. JD031854 - Sequence 12878 from Patent EP1572962. AB056476 - Homo sapiens ARP1 mRNA for angiopoietin-related protein 1, complete cds. AK223467 - Homo sapiens mRNA for angiopoietin-like 1 precursor variant, clone: FCC117F08. JD305155 - Sequence 286179 from Patent EP1572962. JD325309 - Sequence 306333 from Patent EP1572962. AF107253 - Homo sapiens angiopoietin Y1 mRNA, complete cds. KJ904618 - Synthetic construct Homo sapiens clone ccsbBroadEn_14012 ANGPTL1-like gene, encodes complete protein. JD512965 - Sequence 493989 from Patent EP1572962. JD037833 - Sequence 18857 from Patent EP1572962. JD303075 - Sequence 284099 from Patent EP1572962. JD274283 - Sequence 255307 from Patent EP1572962. JD176630 - Sequence 157654 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: ANG3, ANGL1_HUMAN, ANGPT3, ARP1, ENST00000234816.1, ENST00000234816.2, ENST00000234816.3, ENST00000234816.4, ENST00000234816.5, ENST00000234816.6, NM_004673, O95841, PSEC0154, Q5T5Z5, uc317dzr.1, uc317dzr.2, UNQ162/PRO188 UCSC ID: ENST00000234816.7_7 RefSeq Accession: NM_004673.4 Protein: O95841 (aka ANGL1_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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