ID:AKP8L_HUMAN DESCRIPTION: RecName: Full=A-kinase anchor protein 8-like; Short=AKAP8-like protein; AltName: Full=Helicase A-binding protein 95; Short=HAP95; AltName: Full=Homologous to AKAP95 protein; Short=HA95; AltName: Full=Neighbor of A-kinase-anchoring protein 95; Short=Neighbor of AKAP95; FUNCTION: Could play a role in constitutive transport element (CTE)-mediated gene expression. Does not seem to be implicated in the binding of regulatory subunit II of PKA. May be involved in nuclear envelope breakdown and chromatin condensation. May regulate the initiation phase of DNA replication when associated with TMPO-beta. SUBUNIT: Interacts with PRPF40A (By similarity). Binds to the C- terminal of RNA helicase A and to TMPO-beta. Interacts with RNF43. INTERACTION: Q68DV7:RNF43; NbExp=2; IntAct=EBI-357530, EBI-1647060; SUBCELLULAR LOCATION: Nucleus matrix. Cytoplasm. Note=Colocalizes with PRPF40A in the nuclear matrix (By similarity). Nuclear at steady state but shuttles between the nucleus and cytoplasm. Associated with the nuclear matrix. TISSUE SPECIFICITY: Expressed in the brain cortex (at protein level). PTM: Phosphorylated on serine or threonine residues possibly by PKA. SIMILARITY: Belongs to the AKAP95 family. SIMILARITY: Contains 2 C2H2 AKAP95-type zinc fingers. SEQUENCE CAUTION: Sequence=AAF86048.1; Type=Frameshift; Positions=553; Sequence=BAA34791.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9ULX6
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
