ID:AKAP6_HUMAN DESCRIPTION: RecName: Full=A-kinase anchor protein 6; Short=AKAP-6; AltName: Full=A-kinase anchor protein 100 kDa; Short=AKAP 100; AltName: Full=Protein kinase A-anchoring protein 6; Short=PRKA6; AltName: Full=mAKAP; FUNCTION: Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the nuclear membrane or sarcoplasmic reticulum. May act as an adapter for assembling multiprotein complexes. SUBUNIT: Interacts with RII subunit of PKA, phosphatase 2B (calcineurin) and AKAP79. INTERACTION: Q96CV9:OPTN; NbExp=2; IntAct=EBI-1056102, EBI-748974; SUBCELLULAR LOCATION: Sarcoplasmic reticulum. Nucleus membrane. Note=In heart muscle. Participation of multiple targeting signals allow correct intracellular targeting. These may be repeated motifs rich in basic and hydrophobic amino acids, palmitoylated/myristoylated motifs or alternatively splice targeting sequences. TISSUE SPECIFICITY: Highly expressed in cardiac and skeletal muscle, followed by brain. DOMAIN: RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer. SIMILARITY: Contains 2 spectrin repeats. SEQUENCE CAUTION: Sequence=BAA20770.2; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q13023
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001508 action potential GO:0006605 protein targeting GO:0010738 regulation of protein kinase A signaling GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0019933 cAMP-mediated signaling GO:0030307 positive regulation of cell growth GO:0032516 positive regulation of phosphoprotein phosphatase activity GO:0035556 intracellular signal transduction GO:0051281 positive regulation of release of sequestered calcium ion into cytosol GO:0060306 regulation of membrane repolarization GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity GO:0061051 positive regulation of cell growth involved in cardiac muscle cell development GO:0070886 positive regulation of calcineurin-NFAT signaling cascade GO:0071320 cellular response to cAMP GO:0071345 cellular response to cytokine stimulus GO:1901381 positive regulation of potassium ion transmembrane transport GO:1902261 positive regulation of delayed rectifier potassium channel activity
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
