ID:AKAP5_HUMAN DESCRIPTION: RecName: Full=A-kinase anchor protein 5; Short=AKAP-5; AltName: Full=A-kinase anchor protein 79 kDa; Short=AKAP 79; AltName: Full=H21; AltName: Full=cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein; FUNCTION: May anchor the PKA protein to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors. Association with to the beta2-adrenergic receptor (beta2-AR) not only regulates beta2-AR signaling pathway, but also the activation by PKA by switching off the beta2-AR signaling cascade. SUBUNIT: Binding protein for dimer of the RII-beta regulatory subunit of cAMP-dependent protein kinase (PKA) and also for the protein kinase C (PKC) and the phosphatase calcineurin (PP2B). Each enzyme is inhibited when bound to the anchoring protein. Also binds the beta2-adrenergic receptor. Part of a complex containing AKAP5, ADCY5, ADCY6 AND PDE4C (By similarity). Interacts with ADCY8, and enhances its phosphorylation at lipid rafts. INTERACTION: P35561:Kcnj2 (xeno); NbExp=2; IntAct=EBI-703640, EBI-703793; SUBCELLULAR LOCATION: Membrane; Lipid-anchor. Note=Associates with lipid rafts. TISSUE SPECIFICITY: Predominantly in the cerebral cortex and the postsynaptic densities of the forebrain, and to a lesser extent in adrenal medulla, lung and anterior pituitary. DOMAIN: RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer. DOMAIN: The N-terminal region, which is highly basic, is required for interaction with calmodulin. PTM: Palmitoylation at Cys-36 and Cys-129 plays a key role in targeting to lipid rafts. SIMILARITY: Contains 1 AKAP domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P24588
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006605 protein targeting GO:0007165 signal transduction GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway GO:0007268 chemical synaptic transmission GO:0010738 regulation of protein kinase A signaling GO:1903078 positive regulation of protein localization to plasma membrane
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
