ID:AKA10_HUMAN DESCRIPTION: RecName: Full=A-kinase anchor protein 10, mitochondrial; Short=AKAP-10; AltName: Full=Dual specificity A kinase-anchoring protein 2; Short=D-AKAP-2; AltName: Full=Protein kinase A-anchoring protein 10; Short=PRKA10; Flags: Precursor; FUNCTION: Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the downstream kinase (By similarity). SUBCELLULAR LOCATION: Mitochondrion. Membrane. Cytoplasm. Note=Predominantly mitochondrial but also membrane associated and cytoplasmic. DOMAIN: RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer. DISEASE: Genetic variations in AKAP10 are a cause of susceptibility to sudden cardiac death (SCD) [MIM:115080]. Unexpected rapid natural death due to cardiovascular collapse within one hour of initial symptoms. It is usually caused by the worsening of existing heart diseases. The sudden onset of symptoms, such as chest pain and cardiac arrhythmias, particularly ventricular tachycardia, can lead to the loss of consciousness and cardiac arrest followed by biological death. Note=Increased susceptibility to sudden cardiac death may be conferred by AKAP10 variants that are associated with markers of low vagus nerve sensitivity, e.g. fast basal heart rate and low heart rate variability. SIMILARITY: Contains 2 RGS domains.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O43572
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BC017055 - Homo sapiens A kinase (PRKA) anchor protein 10, mRNA (cDNA clone MGC:9414 IMAGE:3882941), complete cds. JD366841 - Sequence 347865 from Patent EP1572962. JD469665 - Sequence 450689 from Patent EP1572962. JD113146 - Sequence 94170 from Patent EP1572962. U00957 - Human clone KDB1.2 (CAC)n/(GTG)n repeat-containing mRNA. JD176073 - Sequence 157097 from Patent EP1572962. JD299774 - Sequence 280798 from Patent EP1572962. JD509022 - Sequence 490046 from Patent EP1572962. JD509792 - Sequence 490816 from Patent EP1572962. JD222286 - Sequence 203310 from Patent EP1572962. JD190595 - Sequence 171619 from Patent EP1572962. JD069023 - Sequence 50047 from Patent EP1572962. AF037439 - Homo sapiens protein kinase A anchoring protein mRNA, complete cds. JD303512 - Sequence 284536 from Patent EP1572962. JD207877 - Sequence 188901 from Patent EP1572962. JD520103 - Sequence 501127 from Patent EP1572962. AK308297 - Homo sapiens cDNA, FLJ98245. DQ891477 - Synthetic construct clone IMAGE:100004107; FLH177332.01X; RZPDo839G05124D A kinase (PRKA) anchor protein 10 (AKAP10) gene, encodes complete protein. AB590263 - Synthetic construct DNA, clone: pFN21AE2233, Homo sapiens AKAP10 gene for A kinase (PRKA) anchor protein 10, without stop codon, in Flexi system. DQ270159 - Homo sapiens mitochondrial A kinase PPKA anchor protein 10 mRNA, complete cds, alternatively spliced; nuclear gene for mitochondrial product. DQ894666 - Synthetic construct Homo sapiens clone IMAGE:100009126; FLH177329.01L; RZPDo839G05123D A kinase (PRKA) anchor protein 10 (AKAP10) gene, encodes complete protein. KU178546 - Homo sapiens A kinase anchor protein 10 isoform 1 (AKAP10) mRNA, partial cds. KU178547 - Homo sapiens A kinase anchor protein 10 isoform 2 (AKAP10) mRNA, complete cds, alternatively spliced. KU178548 - Homo sapiens A kinase anchor protein 10 isoform 3 (AKAP10) mRNA, partial cds, alternatively spliced. KU178549 - Homo sapiens A kinase anchor protein 10 isoform 4 (AKAP10) mRNA, complete cds, alternatively spliced. KU178550 - Homo sapiens A kinase anchor protein 10 isoform 5 (AKAP10) mRNA, partial cds, alternatively spliced. AK312438 - Homo sapiens cDNA, FLJ92785, Homo sapiens A kinase (PRKA) anchor protein 10 (AKAP10), nucleargene encoding mitochondrial protein, mRNA. BC111518 - Homo sapiens cDNA clone IMAGE:40018207. AK295180 - Homo sapiens cDNA FLJ51690 complete cds, weakly similar to A kinase anchor protein 10, mitochondrial precursor. CU677815 - Synthetic construct Homo sapiens gateway clone IMAGE:100019988 5' read AKAP10 mRNA. DQ600654 - Homo sapiens piRNA piR-38720, complete sequence. JD226897 - Sequence 207921 from Patent EP1572962. JD181851 - Sequence 162875 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein O43572 (Reactome details) participates in the following event(s):
R-HSA-992708 Dual-specific AKAPs bind type I and II PKA regulatory subunits R-HSA-983231 Factors involved in megakaryocyte development and platelet production R-HSA-109582 Hemostasis
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
