Human Gene AHCYL2 (ENST00000325006.8_8) from GENCODE V47lift37
  Description: adenosylhomocysteinase like 2, transcript variant 10 (from RefSeq NR_171671.1)
Gencode Transcript: ENST00000325006.8_8
Gencode Gene: ENSG00000158467.17_13
Transcript (Including UTRs)
   Position: hg19 chr7:128,864,871-129,070,052 Size: 205,182 Total Exon Count: 17 Strand: +
Coding Region
   Position: hg19 chr7:128,864,918-129,066,886 Size: 201,969 Coding Exon Count: 17 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:128,864,871-129,070,052)mRNA (may differ from genome)Protein (611 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblExonPrimerGeneCardsHGNC
MGIPubMedReactomeUniProtKB

-  Comments and Description Text from UniProtKB
  ID: SAHH3_HUMAN
DESCRIPTION: RecName: Full=Putative adenosylhomocysteinase 3; Short=AdoHcyase 3; EC=3.3.1.1; AltName: Full=S-adenosyl-L-homocysteine hydrolase 3; AltName: Full=S-adenosylhomocysteine hydrolase-like protein 2;
CATALYTIC ACTIVITY: S-adenosyl-L-homocysteine + H(2)O = L- homocysteine + adenosine.
COFACTOR: Binds 1 NAD per subunit.
PATHWAY: Amino-acid biosynthesis; L-homocysteine biosynthesis; L- homocysteine from S-adenosyl-L-homocysteine: step 1/1.
SUBUNIT: Homotetramer (Probable).
SIMILARITY: Belongs to the adenosylhomocysteinase family.
SEQUENCE CAUTION: Sequence=BAA74851.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 35.61 RPKM in Colon - Transverse
Total median expression: 423.23 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -12.6047-0.268 Picture PostScript Text
3' UTR -877.373166-0.277 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000043 - Adenosylhomocysteinase
IPR015878 - Ado_hCys_hydrolase_NAD-bd
IPR020082 - S-Ado-L-homoCys_hydrolase_CS

Pfam Domains:
PF00670 - S-adenosyl-L-homocysteine hydrolase, NAD binding domain
PF02826 - D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
PF05221 - S-adenosyl-L-homocysteine hydrolase

SCOP Domains:
69572 - Activating enzymes of the ubiquitin-like proteins
51735 - NAD(P)-binding Rossmann-fold domains
52283 - Formate/glycerate dehydrogenase catalytic domain-like
51905 - FAD/NAD(P)-binding domain
52440 - PreATP-grasp domain
51984 - MurCD N-terminal domain

Protein Data Bank (PDB) 3-D Structure
MuPIT help
3GVP - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on Q96HN2
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details Gene Details  
Gene SorterGene Sorter Gene Sorter  
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0004013 adenosylhomocysteinase activity

Biological Process:
GO:0006730 one-carbon metabolic process
GO:0033353 S-adenosylmethionine cycle

Cellular Component:
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0043005 neuron projection
GO:0043231 intracellular membrane-bounded organelle


-  Descriptions from all associated GenBank mRNAs
  LF207063 - JP 2014500723-A/14566: Polycomb-Associated Non-Coding RNAs.
BC024325 - Homo sapiens S-adenosylhomocysteine hydrolase-like 2, mRNA (cDNA clone MGC:21525 IMAGE:3907552), complete cds.
AB020635 - Homo sapiens KIAA0828 mRNA for KIAA0828 protein.
BC008349 - Homo sapiens S-adenosylhomocysteine hydrolase-like 2, mRNA (cDNA clone MGC:15925 IMAGE:3536052), complete cds.
AB384003 - Synthetic construct DNA, clone: pF1KSDA0828, Homo sapiens SAHH3 gene for adenosylhomocysteinase 3, complete cds, without stop codon, in Flexi system.
KJ893363 - Synthetic construct Homo sapiens clone ccsbBroadEn_02757 AHCYL2 gene, encodes complete protein.
AK130743 - Homo sapiens cDNA FLJ27233 fis, clone SYN06481, highly similar to Adenosylhomocysteinase (EC 3.3.1.1).
MA442640 - JP 2018138019-A/14566: Polycomb-Associated Non-Coding RNAs.
JD158255 - Sequence 139279 from Patent EP1572962.
JD541181 - Sequence 522205 from Patent EP1572962.
JD206188 - Sequence 187212 from Patent EP1572962.
AK129958 - Homo sapiens cDNA FLJ26448 fis, clone KDN02955.
JD472150 - Sequence 453174 from Patent EP1572962.
LF360954 - JP 2014500723-A/168457: Polycomb-Associated Non-Coding RNAs.
MA596531 - JP 2018138019-A/168457: Polycomb-Associated Non-Coding RNAs.
AK025372 - Homo sapiens cDNA: FLJ21719 fis, clone COLF0094.
AK316073 - Homo sapiens cDNA, FLJ78972 complete cds, highly similar to Putative adenosylhomocysteinase 3 (EC 3.3.1.1).
AK295851 - Homo sapiens cDNA FLJ59697 complete cds, highly similar to Putative adenosylhomocysteinase 3 (EC 3.3.1.1).
LF360983 - JP 2014500723-A/168486: Polycomb-Associated Non-Coding RNAs.
LF360984 - JP 2014500723-A/168487: Polycomb-Associated Non-Coding RNAs.
AK172759 - Homo sapiens cDNA FLJ23920 fis, clone COL02027.
JD491314 - Sequence 472338 from Patent EP1572962.
JD313603 - Sequence 294627 from Patent EP1572962.
JD243762 - Sequence 224786 from Patent EP1572962.
JD209684 - Sequence 190708 from Patent EP1572962.
JD209685 - Sequence 190709 from Patent EP1572962.
JD476443 - Sequence 457467 from Patent EP1572962.
JD297895 - Sequence 278919 from Patent EP1572962.
LF360989 - JP 2014500723-A/168492: Polycomb-Associated Non-Coding RNAs.
JD315750 - Sequence 296774 from Patent EP1572962.
JD099824 - Sequence 80848 from Patent EP1572962.
JD363258 - Sequence 344282 from Patent EP1572962.
JD048357 - Sequence 29381 from Patent EP1572962.
JD340625 - Sequence 321649 from Patent EP1572962.
JD296466 - Sequence 277490 from Patent EP1572962.
JD337152 - Sequence 318176 from Patent EP1572962.
JD320979 - Sequence 302003 from Patent EP1572962.
JD368524 - Sequence 349548 from Patent EP1572962.
JD378920 - Sequence 359944 from Patent EP1572962.
JD262772 - Sequence 243796 from Patent EP1572962.
LF360990 - JP 2014500723-A/168493: Polycomb-Associated Non-Coding RNAs.
JD323966 - Sequence 304990 from Patent EP1572962.
JD562277 - Sequence 543301 from Patent EP1572962.
JD434270 - Sequence 415294 from Patent EP1572962.
JD154673 - Sequence 135697 from Patent EP1572962.
JD433141 - Sequence 414165 from Patent EP1572962.
JD559839 - Sequence 540863 from Patent EP1572962.
JD103407 - Sequence 84431 from Patent EP1572962.
JD297578 - Sequence 278602 from Patent EP1572962.
JD333584 - Sequence 314608 from Patent EP1572962.
JD515104 - Sequence 496128 from Patent EP1572962.
JD528813 - Sequence 509837 from Patent EP1572962.
LF360991 - JP 2014500723-A/168494: Polycomb-Associated Non-Coding RNAs.
JD122579 - Sequence 103603 from Patent EP1572962.
JD254976 - Sequence 236000 from Patent EP1572962.
JD155342 - Sequence 136366 from Patent EP1572962.
JD290466 - Sequence 271490 from Patent EP1572962.
JD289568 - Sequence 270592 from Patent EP1572962.
JD546063 - Sequence 527087 from Patent EP1572962.
JD509440 - Sequence 490464 from Patent EP1572962.
JD287700 - Sequence 268724 from Patent EP1572962.
JD248293 - Sequence 229317 from Patent EP1572962.
JD567003 - Sequence 548027 from Patent EP1572962.
JD565939 - Sequence 546963 from Patent EP1572962.
JD248489 - Sequence 229513 from Patent EP1572962.
JD369782 - Sequence 350806 from Patent EP1572962.
JD559288 - Sequence 540312 from Patent EP1572962.
JD428852 - Sequence 409876 from Patent EP1572962.
JD484549 - Sequence 465573 from Patent EP1572962.
JD358901 - Sequence 339925 from Patent EP1572962.
JD316354 - Sequence 297378 from Patent EP1572962.
JD394248 - Sequence 375272 from Patent EP1572962.
JD548596 - Sequence 529620 from Patent EP1572962.
JD496024 - Sequence 477048 from Patent EP1572962.
JD072947 - Sequence 53971 from Patent EP1572962.
JD164104 - Sequence 145128 from Patent EP1572962.
JD134324 - Sequence 115348 from Patent EP1572962.
JD189213 - Sequence 170237 from Patent EP1572962.
JD433070 - Sequence 414094 from Patent EP1572962.
JD047319 - Sequence 28343 from Patent EP1572962.
MA596560 - JP 2018138019-A/168486: Polycomb-Associated Non-Coding RNAs.
MA596561 - JP 2018138019-A/168487: Polycomb-Associated Non-Coding RNAs.
MA596566 - JP 2018138019-A/168492: Polycomb-Associated Non-Coding RNAs.
MA596567 - JP 2018138019-A/168493: Polycomb-Associated Non-Coding RNAs.
MA596568 - JP 2018138019-A/168494: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: B4DIZ5, D9N155, ENST00000325006.1, ENST00000325006.2, ENST00000325006.3, ENST00000325006.4, ENST00000325006.5, ENST00000325006.6, ENST00000325006.7, KIAA0828, NR_171671, O94917, Q96HN2, SAHH3_HUMAN, uc317rud.1, uc317rud.2
UCSC ID: ENST00000325006.8_8
RefSeq Accession: NM_015328.4
Protein: Q96HN2 (aka SAHH3_HUMAN or SAH3_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.