ID:AGGF1_HUMAN DESCRIPTION: RecName: Full=Angiogenic factor with G patch and FHA domains 1; AltName: Full=Angiogenic factor VG5Q; Short=hVG5Q; AltName: Full=G patch domain-containing protein 7; AltName: Full=Vasculogenesis gene on 5q protein; FUNCTION: Promotes angiogenesis and the proliferation of endothelial cells. Able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion. SUBUNIT: Interacts with the secreted angiogenic factor TNFSF12. SUBCELLULAR LOCATION: Cytoplasm. Secreted. Note=Cytoplasmic in microvascular endothelial cells. Upon angiogenesis, when endothelial cell tube formation is initiated, it is secreted. TISSUE SPECIFICITY: Widely expressed. Expressed in endothelial cells, vascular smooth muscle cells and osteoblasts. Expressed in umbilical vein endothelial cells and microvascular endothelial cells. DISEASE: Defects in AGGF1 are a cause of Klippel-Trenaunay syndrome (KTS) [MIM:149000]. KTS is a congenital disease characterized by malformations of capillary (98% of KTS patients), venous (72%) and lymphatic (11%) vessels, and bony and soft tissue hypertrophy that leads to large cutaneous hemangiomata with hypertrophy of the related bones and soft tissues. SIMILARITY: Contains 1 FHA domain. SIMILARITY: Contains 1 G-patch domain. SEQUENCE CAUTION: Sequence=AAH29382.2; Type=Erroneous termination; Positions=708; Note=Translated as Trp; Sequence=BAA91519.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8N302
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BC032844 - Homo sapiens angiogenic factor with G patch and FHA domains 1, mRNA (cDNA clone MGC:32998 IMAGE:5266978), complete cds. BC002828 - Homo sapiens angiogenic factor with G patch and FHA domains 1, mRNA (cDNA clone IMAGE:3659316), complete cds. U84971 - Homo sapiens fetal unknown mRNA, complete cds. JD174589 - Sequence 155613 from Patent EP1572962. AY500994 - Homo sapiens angiogenic factor VG5Q mRNA, complete cds. JD153409 - Sequence 134433 from Patent EP1572962. BC073864 - Homo sapiens angiogenic factor with G patch and FHA domains 1, mRNA (cDNA clone IMAGE:4498580). JD271842 - Sequence 252866 from Patent EP1572962. JD137786 - Sequence 118810 from Patent EP1572962. JF432544 - Synthetic construct Homo sapiens clone IMAGE:100073767 angiogenic factor with G patch and FHA domains 1 (AGGF1) gene, encodes complete protein. KJ902764 - Synthetic construct Homo sapiens clone ccsbBroadEn_12158 AGGF1 gene, encodes complete protein. CU689558 - Synthetic construct Homo sapiens gateway clone IMAGE:100022692 5' read AGGF1 mRNA. KJ899077 - Synthetic construct Homo sapiens clone ccsbBroadEn_08471 AGGF1 gene, encodes complete protein. JD019035 - Sequence 59 from Patent EP1572962. JD028323 - Sequence 9347 from Patent EP1572962. JD033015 - Sequence 14039 from Patent EP1572962. AK289394 - Homo sapiens cDNA FLJ75192 complete cds. BX648120 - Homo sapiens mRNA; cDNA DKFZp686L1440 (from clone DKFZp686L1440). BC015478 - Homo sapiens angiogenic factor with G patch and FHA domains 1, mRNA (cDNA clone IMAGE:3885345), partial cds. AK001145 - Homo sapiens cDNA FLJ10283 fis, clone HEMBB1001339, weakly similar to DXS8237E PROTEIN. JD309005 - Sequence 290029 from Patent EP1572962. JD326193 - Sequence 307217 from Patent EP1572962. JD411122 - Sequence 392146 from Patent EP1572962. BC029382 - Homo sapiens angiogenic factor with G patch and FHA domains 1, mRNA (cDNA clone IMAGE:4252711), partial cds. AK097255 - Homo sapiens cDNA FLJ39936 fis, clone SPLEN2021795. JD548774 - Sequence 529798 from Patent EP1572962. JD020774 - Sequence 1798 from Patent EP1572962. JD032951 - Sequence 13975 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q8N302 (Reactome details) participates in the following event(s):
R-HSA-6802927 BRAF and RAF fusion mutant dimers are phosphorylated R-HSA-6802934 p-BRAF and RAF fusion dimers bind MAP2Ks and MAPKs R-HSA-6802932 Dissociation of BRAF/RAF fusion complex R-HSA-6802933 p-BRAF and RAF fusion dimers phosphorylate MAP2Ks R-HSA-6802935 MAPKs are phosphorylated downstream of BRAF and RAF fusion dimers R-HSA-6802952 Signaling by BRAF and RAF fusions R-HSA-6802957 Oncogenic MAPK signaling R-HSA-5663202 Diseases of signal transduction R-HSA-1643685 Disease
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
