ID:AF1L2_HUMAN DESCRIPTION: RecName: Full=Actin filament-associated protein 1-like 2; Short=AFAP1-like protein 2; FUNCTION: May play a role in a signaling cascade by enhancing the kinase activity of SRC. Contributes to SRC-regulated transcription activation. SUBUNIT: Interacts with SRC. Interacts with LCK when tyrosine phosphorylated. SUBCELLULAR LOCATION: Cytoplasm. TISSUE SPECIFICITY: Detected in spleen and thyroid, and at lower levels in kidney, brain, lung and pancreas. PTM: Tyrosine phosphorylated (by SRC). SIMILARITY: Contains 2 PH domains. SEQUENCE CAUTION: Sequence=BAB67807.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8N4X5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006954 inflammatory response GO:0007346 regulation of mitotic cell cycle GO:0009966 regulation of signal transduction GO:0032675 regulation of interleukin-6 production GO:0032757 positive regulation of interleukin-8 production GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway GO:0045893 positive regulation of transcription, DNA-templated GO:0061098 positive regulation of protein tyrosine kinase activity
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
