Human Gene ADRA2B (ENST00000620793.2_7) from GENCODE V47lift37
  Description: adrenoceptor alpha 2B (from RefSeq NM_000682.7)
Gencode Transcript: ENST00000620793.2_7
Gencode Gene: ENSG00000274286.2_9
Transcript (Including UTRs)
   Position: hg19 chr2:96,778,624-96,782,310 Size: 3,687 Total Exon Count: 1 Strand: -
Coding Region
   Position: hg19 chr2:96,780,545-96,781,888 Size: 1,344 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:96,778,624-96,782,310)mRNA (may differ from genome)Protein (447 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCHuman Cortex Gene ExpressionMalacardsMGIOMIMPubMed
ReactomeUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ADA2B_HUMAN
DESCRIPTION: RecName: Full=Alpha-2B adrenergic receptor; AltName: Full=Alpha-2 adrenergic receptor subtype C2; AltName: Full=Alpha-2B adrenoreceptor; Short=Alpha-2B adrenoceptor; Short=Alpha-2BAR;
FUNCTION: Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
POLYMORPHISM: A rare polymorphic framshift in position 451 produces a protein of 542 residues.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2B sub-subfamily.
WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/adra2b/";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: ADRA2B
Diseases sorted by gene-association score: epilepsy, myoclonic, familial adult, 2* (1000), benign adult familial myoclonic epilepsy* (350), atrial septal defect 2 (8), orthostatic intolerance (6), obesity (1), hypertension, essential (1)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -219.10422-0.519 Picture PostScript Text
3' UTR -780.101921-0.406 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR000207 - Adren_rcpt_A2B
IPR002233 - Adrnrgc_rcpt
IPR017452 - GPCR_Rhodpsn_supfam

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)
PF10320 - Serpentine type 7TM GPCR chemoreceptor Srsx
PF13853 - Olfactory receptor

SCOP Domains:
81321 - Family A G protein-coupled receptor-like

Protein Data Bank (PDB) 3-D Structure
MuPIT help
2CVA - Model


ModBase Predicted Comparative 3D Structure on P18089
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0004935 adrenergic receptor activity
GO:0004938 alpha2-adrenergic receptor activity
GO:0005515 protein binding
GO:0051379 epinephrine binding

Biological Process:
GO:0000187 activation of MAPK activity
GO:0003056 regulation of vascular smooth muscle contraction
GO:0006940 regulation of smooth muscle contraction
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007267 cell-cell signaling
GO:0007565 female pregnancy
GO:0010700 negative regulation of norepinephrine secretion
GO:0019229 regulation of vasoconstriction
GO:0030168 platelet activation
GO:0032148 activation of protein kinase B activity
GO:0032811 negative regulation of epinephrine secretion
GO:0035625 epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway
GO:0043410 positive regulation of MAPK cascade
GO:0045666 positive regulation of neuron differentiation
GO:0045777 positive regulation of blood pressure
GO:0070474 positive regulation of uterine smooth muscle contraction
GO:0071875 adrenergic receptor signaling pathway
GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway

Cellular Component:
GO:0005622 intracellular
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  BC133021 - Homo sapiens adrenergic, alpha-2B-, receptor, mRNA (cDNA clone MGC:164652 IMAGE:40147043), complete cds.
BC136537 - Homo sapiens adrenergic, alpha-2B-, receptor, mRNA (cDNA clone MGC:168150 IMAGE:9020527), complete cds.
JD061134 - Sequence 42158 from Patent EP1572962.
JD279162 - Sequence 260186 from Patent EP1572962.
JD220689 - Sequence 201713 from Patent EP1572962.
JD201702 - Sequence 182726 from Patent EP1572962.
JD365394 - Sequence 346418 from Patent EP1572962.
JD379164 - Sequence 360188 from Patent EP1572962.
JD054920 - Sequence 35944 from Patent EP1572962.
JD389774 - Sequence 370798 from Patent EP1572962.
JD201925 - Sequence 182949 from Patent EP1572962.
JD488068 - Sequence 469092 from Patent EP1572962.
JD381662 - Sequence 362686 from Patent EP1572962.
JD556253 - Sequence 537277 from Patent EP1572962.
JD223851 - Sequence 204875 from Patent EP1572962.
JD176032 - Sequence 157056 from Patent EP1572962.
JD466534 - Sequence 447558 from Patent EP1572962.
JD320851 - Sequence 301875 from Patent EP1572962.
JD521926 - Sequence 502950 from Patent EP1572962.
JD556167 - Sequence 537191 from Patent EP1572962.
JD475624 - Sequence 456648 from Patent EP1572962.
JD453080 - Sequence 434104 from Patent EP1572962.
JD117339 - Sequence 98363 from Patent EP1572962.
JD400895 - Sequence 381919 from Patent EP1572962.
JD127301 - Sequence 108325 from Patent EP1572962.
JD043180 - Sequence 24204 from Patent EP1572962.
JD539145 - Sequence 520169 from Patent EP1572962.
JD047917 - Sequence 28941 from Patent EP1572962.
JD439703 - Sequence 420727 from Patent EP1572962.
JD400293 - Sequence 381317 from Patent EP1572962.
JD219440 - Sequence 200464 from Patent EP1572962.
KJ896391 - Synthetic construct Homo sapiens clone ccsbBroadEn_05785 ADRA2B gene, encodes complete protein.
AB527942 - Synthetic construct DNA, clone: pF1KB0982, Homo sapiens ADRA2B gene for adrenergic, alpha-2B-, receptor, without stop codon, in Flexi system.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P18089 (Reactome details) participates in the following event(s):

R-HSA-390663 Alpha-2 adrenoceptors bind catecholamines
R-HSA-751024 The Ligand:GPCR:Gz complex dissociates
R-HSA-749446 Liganded Gz-activating GPCRs bind inactive heterotrimeric G-protein Gz
R-HSA-749454 The Ligand:GPCR:Gi complex dissociates
R-HSA-749453 Liganded Gz-activating GPCR acts as a GEF for Gz
R-HSA-749456 Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi
R-HSA-380073 Liganded Gi-activating GPCR acts as a GEF for Gi
R-HSA-390696 Adrenoceptors
R-HSA-392023 Adrenaline signalling through Alpha-2 adrenergic receptor
R-HSA-418597 G alpha (z) signalling events
R-HSA-418594 G alpha (i) signalling events
R-HSA-375280 Amine ligand-binding receptors
R-HSA-76009 Platelet Aggregation (Plug Formation)
R-HSA-388396 GPCR downstream signalling
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-76002 Platelet activation, signaling and aggregation
R-HSA-372790 Signaling by GPCR
R-HSA-500792 GPCR ligand binding
R-HSA-109582 Hemostasis
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: A2RUS0, ADA2B_HUMAN, ADRA2L1, ADRA2RL1, ENST00000620793.1, NM_000682, P18089, Q4TUH9, Q53RF2, Q9BZK0, uc327tge.1, uc327tge.2
UCSC ID: ENST00000620793.2_7
RefSeq Accession: NM_000682.7
Protein: P18089 (aka ADA2B_HUMAN or A2AB_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.