Human Gene ADORA3 (ENST00000241356.5_6) from GENCODE V47lift37

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Description: adenosine A3 receptor, transcript variant C (from RefSeq NM_001302679.2)
Gencode Transcript: ENST00000241356.5_6
Gencode Gene: ENSG00000282608.2_7
Transcript (Including UTRs)
Position: hg19 chr1:112,042,051-112,046,255 Size: 4,205 Total Exon Count: 2 Strand: -
Coding Region
Position: hg19 chr1:112,042,572-112,045,976 Size: 3,405 Coding Exon Count: 2

Page Index	Sequence and Links	Primers	MalaCards	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Other Species	mRNA Descriptions	Other Names
Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr1:112,042,051-112,046,255)			mRNA (may differ from genome)		Protein (318 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Human Cortex Gene Expression	Malacards	MGI	OMIM	PubMed
UniProtKB	Wikipedia	BioGrid CRISPR DB

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: ADORA3 Diseases sorted by gene-association score: ischemia (23), reflex epilepsy (7)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene C107562 2-chloro-N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine C084956 N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine C419146 2,3-diethyl-4,5-dipropyl-6-phenylpyridine-3-thiocarboxylate-5-carboxylate C110041 9-chloro-2-(2-furyl)-5-phenylacetylamino(1,2,4)triazolo(1,5-c)quinazoline D000241 Adenosine C478920 CF101 D008070 Lipopolysaccharides C107728 MRS 1191 D008727 Methotrexate C001073 2,4-dinitrobenzenesulfonic acid D015762 2-Chloroadenosine C090034 2-chloro-N(6)-(3-iodobenzyl)adenosine-5'-N-methyluronamide D000638 Amiodarone D000643 Ammonium Chloride D001241 Aspirin D001564 Benzo(a)pyrene D019256 Cadmium Chloride D002251 Carbon Tetrachloride D002713 Chlorine D019327 Copper Sulfate D004205 Cromolyn Sodium D003907 Dexamethasone D004051 Diethylhexyl Phthalate D004176 Dipyridamole D016291 Dizocilpine Maleate D007213 Indomethacin C523799 MRK 003 D008694 Methamphetamine D010126 Ozone C075004 PD 81723 D010634 Phenobarbital D010656 Phenylephrine D011224 Prazosin D011720 Pyrazoles D011804 Quinolines D012601 Scopolamine Hydrobromide D013749 Tetrachlorodibenzodioxin D014212 Tretinoin C438612 VUF 5455 C008436 adenosine 5'-methylenediphosphate C523965 alpha,beta-methyleneadenosine 5'-diphosphate C018021 cobaltous chloride C014476 diethyl maleate C043680 ptaquiloside C059514 resveratrol C061133 tamibarotene

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 13.26 RPKM in Testis Total median expression: 84.58 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-89.60	279	-0.321	Picture	PostScript	Text
3' UTR	-145.40	521	-0.279	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details
Gene Sorter

Descriptions from all associated GenBank mRNAs


	KJ896389 - Synthetic construct Homo sapiens clone ccsbBroadEn_05783 ADORA3 gene, encodes complete protein. KR710784 - Synthetic construct Homo sapiens clone CCSBHm_00017084 ADORA3 (ADORA3) mRNA, encodes complete protein. AY358644 - Homo sapiens clone DNA45408 adenosine receptor (UNQ1931) mRNA, complete cds. BC029831 - Homo sapiens adenosine A3 receptor, mRNA (cDNA clone MGC:34402 IMAGE:5176221), complete cds. L20463 - Human A3 adenosine receptor mRNA, complete cds. L22607 - Homo sapiens A3 adenosine receptor mRNA, complete cds. X76981 - H.sapiens mRNA for adenosin receptor A3. JD471589 - Sequence 452613 from Patent EP1572962. JD282512 - Sequence 263536 from Patent EP1572962. JD168917 - Sequence 149941 from Patent EP1572962. JD042818 - Sequence 23842 from Patent EP1572962. JD368486 - Sequence 349510 from Patent EP1572962. JD153945 - Sequence 134969 from Patent EP1572962. JD101237 - Sequence 82261 from Patent EP1572962. JD403022 - Sequence 384046 from Patent EP1572962. JN855714 - Homo sapiens adenosine receptor A3 mRNA, partial cds, alternatively spliced. JD306222 - Sequence 287246 from Patent EP1572962. JD085696 - Sequence 66720 from Patent EP1572962. AY136749 - Homo sapiens adenosine receptor A3 (ADORA3) mRNA, complete cds. DQ892449 - Synthetic construct clone IMAGE:100005079; FLH186433.01X; RZPDo839E0671D adenosine A3 receptor (ADORA3) gene, encodes complete protein. AK313095 - Homo sapiens cDNA, FLJ93579, highly similar to Homo sapiens adenosine A3 receptor (ADORA3), transcript variant 2, mRNA. DQ895661 - Synthetic construct Homo sapiens clone IMAGE:100010121; FLH186429.01L; RZPDo839E0661D adenosine A3 receptor (ADORA3) gene, encodes complete protein. AB527636 - Synthetic construct DNA, clone: pF1KB5419, Homo sapiens ADORA3 gene for adenosine A3 receptor, without stop codon, in Flexi system. CU688760 - Synthetic construct Homo sapiens gateway clone IMAGE:100018882 5' read ADORA3 mRNA. JD332847 - Sequence 313871 from Patent EP1572962. JD309076 - Sequence 290100 from Patent EP1572962. JD276818 - Sequence 257842 from Patent EP1572962. JD261926 - Sequence 242950 from Patent EP1572962. JD061016 - Sequence 42040 from Patent EP1572962. JD174775 - Sequence 155799 from Patent EP1572962. JD330348 - Sequence 311372 from Patent EP1572962. JD219308 - Sequence 200332 from Patent EP1572962. JD045792 - Sequence 26816 from Patent EP1572962. JD532985 - Sequence 514009 from Patent EP1572962. JD444646 - Sequence 425670 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: A2A3P4, AA3R_HUMAN, ADORA3 , ENST00000241356.1, ENST00000241356.2, ENST00000241356.3, ENST00000241356.4, NM_001302679, P0DMS8, P33765, Q6UWU0, Q9BYZ1, uc317eit.1, uc317eit.2 UCSC ID: ENST00000241356.5_6 RefSeq Accession: NM_000677.4

Gene Model Information


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Methods, Credits, and Use Restrictions


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