ID:ADNP_HUMAN DESCRIPTION: RecName: Full=Activity-dependent neuroprotector homeobox protein; AltName: Full=Activity-dependent neuroprotective protein; FUNCTION: Potential transcription factor. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation. INTERACTION: P83916:CBX1; NbExp=2; IntAct=EBI-1764854, EBI-78129; Q13185:CBX3; NbExp=2; IntAct=EBI-1764854, EBI-78176; P45973:CBX5; NbExp=2; IntAct=EBI-1764854, EBI-78219; SUBCELLULAR LOCATION: Nucleus (Potential). TISSUE SPECIFICITY: Widely expressed. Strong expression in heart, skeletal muscle, kidney and placenta. In brain, expression is stronger in the cerebellum and cortex regions. No expression detected in the colon. Strong increase of expression in colon and breast cancer tissues. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. MISCELLANEOUS: When isolated from the sequence, neuroprotective peptide (NAP) provides neuroprotection against the beta-amyloid peptide. SIMILARITY: Contains 9 C2H2-type zinc fingers. SIMILARITY: Contains 1 homeobox DNA-binding domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9H2P0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0007614 short-term memory GO:0009743 response to carbohydrate GO:0010035 response to inorganic substance GO:0010629 negative regulation of gene expression GO:0010835 regulation of protein ADP-ribosylation GO:0010976 positive regulation of neuron projection development GO:0030828 positive regulation of cGMP biosynthetic process GO:0031668 cellular response to extracellular stimulus GO:0032091 negative regulation of protein binding GO:0032147 activation of protein kinase activity GO:0033484 nitric oxide homeostasis GO:0043524 negative regulation of neuron apoptotic process GO:0044849 estrous cycle GO:0045773 positive regulation of axon extension GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation GO:0050805 negative regulation of synaptic transmission GO:0051965 positive regulation of synapse assembly
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
