Human Gene ADH7 (ENST00000437033.7_7) from GENCODE V47lift37

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Description: alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide, transcript variant 2 (from RefSeq NM_000673.7)
Gencode Transcript: ENST00000437033.7_7
Gencode Gene: ENSG00000196344.12_9
Transcript (Including UTRs)
Position: hg19 chr4:100,333,420-100,356,499 Size: 23,080 Total Exon Count: 9 Strand: -
Coding Region
Position: hg19 chr4:100,334,305-100,356,390 Size: 22,086 Coding Exon Count: 9

Page Index	Sequence and Links	Primers	MalaCards	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Other Species	mRNA Descriptions	Other Names
Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr4:100,333,420-100,356,499)			mRNA (may differ from genome)		Protein (374 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	OMIM	PubMed	UniProtKB
Wikipedia	BioGrid CRISPR DB

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: ADH7 Diseases sorted by gene-association score: atrophic gastritis (13), alcohol dependence (10), gastritis (7), fetal alcohol spectrum disorder (5), fetal alcohol syndrome (4)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D013749 Tetrachlorodibenzodioxin C076994 perfluorooctane sulfonic acid C028474 1,4-bis(2-(3,5-dichloropyridyloxy))benzene C015802 2,6-dichloro-4-nitrophenol C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester D019840 2-Propanol C018855 2-tert-butylhydroquinone C023035 3,4,5,3',4'-pentachlorobiphenyl C027576 4-hydroxy-2-nonenal D000082 Acetaminophen D000643 Ammonium Chloride D001564 Benzo(a)pyrene D002737 Chloroprene D002794 Choline D002994 Clofibrate D004052 Diethylnitrosamine D004237 Diuron D000431 Ethanol D019855 Ethylene Glycol D005492 Folic Acid D006861 Hydrogen Peroxide C525593 JK184 C098607 JP8 aviation fuel D008715 Methionine D008748 Methylcholanthrene D010416 Pentachlorophenol D010634 Phenobarbital D012172 Retinaldehyde D014028 Tobacco Smoke Pollution D014801 Vitamin A D014810 Vitamin E C000188 alachlor C030419 andrographolide D019324 beta-Naphthoflavone C551172 bis-N,N-dimethylamino-2-(N-methylpyrrolyl)methyl cyclopentadienyl titanium (IV) C023614 dibenzofuran C010238 fomepizole C039281 furan C014707 nitrosobenzylmethylamine C016030 pantogab C023036 perfluorooctanoic acid C006253 pirinixic acid D020122 tert-Butylhydroperoxide C501413 tesaglitazar C057693 troglitazone C574123 walrycin A

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 91.50 RPKM in Esophagus - Mucosa Total median expression: 93.69 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-21.30	109	-0.195	Picture	PostScript	Text
3' UTR	-157.60	885	-0.178	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Descriptions from all associated GenBank mRNAs


	X76342 - H.sapiens ADH7 mRNA. U09623 - Human alcohol dehydrogenase (ADH7) mRNA, complete cds. JD410826 - Sequence 391850 from Patent EP1572962. JD337261 - Sequence 318285 from Patent EP1572962. JD565943 - Sequence 546967 from Patent EP1572962. U07821 - Human alcohol dehydrogenase (ADH7) mRNA, complete cds. JD284758 - Sequence 265782 from Patent EP1572962. BC131512 - Homo sapiens alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide, mRNA (cDNA clone MGC:138874 IMAGE:40083994), complete cds. JD158414 - Sequence 139438 from Patent EP1572962. AK223472 - Homo sapiens mRNA, class IV alcohol dehydrogenase 7 mu or sigma subunit variant, clone: FCC118A08. JD357894 - Sequence 338918 from Patent EP1572962. JD288616 - Sequence 269640 from Patent EP1572962. JD043054 - Sequence 24078 from Patent EP1572962. JD524387 - Sequence 505411 from Patent EP1572962. AK301696 - Homo sapiens cDNA FLJ51127 complete cds, highly similar to Alcohol dehydrogenase class 4 mu/sigma chain (EC 1.1.1.1). JD089341 - Sequence 70365 from Patent EP1572962. JD346969 - Sequence 327993 from Patent EP1572962. AK301657 - Homo sapiens cDNA FLJ51125 complete cds, highly similar to Alcohol dehydrogenase class 4 mu/sigma chain (EC 1.1.1.1). JD206816 - Sequence 187840 from Patent EP1572962. L33179 - Human class IV sigma-1 alcohol dehydrogenase mRNA, complete cds. AK312854 - Homo sapiens cDNA, FLJ93297, highly similar to Homo sapiens alcohol dehydrogenase 7 (class IV), mu or sigmapolypeptide (ADH7), mRNA. KJ890635 - Synthetic construct Homo sapiens clone ccsbBroadEn_00029 ADH7 gene, encodes complete protein. AK310811 - Homo sapiens cDNA, FLJ17853. S77168 - ADH7=class IV alcohol dehydrogenase [human, stomach, mRNA Partial, 219 nt]. JD090286 - Sequence 71310 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: A0A0C4DG85, A0A0C4DG85_HUMAN, ADH7 , ENST00000437033.1, ENST00000437033.2, ENST00000437033.3, ENST00000437033.4, ENST00000437033.5, ENST00000437033.6, NM_000673, uc320fjp.1, uc320fjp.2 UCSC ID: ENST00000437033.7_7 RefSeq Accession: NM_000673.7

Gene Model Information


	Click here for a detailed description of the fields of the table above.

Methods, Credits, and Use Restrictions


	Click here for details on how this gene model was made and data restrictions if any.