Human Gene ACTR2 (ENST00000260641.10_12) from GENCODE V47lift37

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Description: actin related protein 2, transcript variant 2 (from RefSeq NM_005722.4)
Gencode Transcript: ENST00000260641.10_12
Gencode Gene: ENSG00000138071.15_15
Transcript (Including UTRs)
Position: hg19 chr2:65,454,965-65,498,387 Size: 43,423 Total Exon Count: 9 Strand: +
Coding Region
Position: hg19 chr2:65,455,044-65,495,868 Size: 40,825 Coding Exon Count: 9

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species
GO Annotations	mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr2:65,454,965-65,498,387)			mRNA (may differ from genome)		Protein (394 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	OMIM	PubMed	Reactome
UniProtKB	Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: ARP2_HUMAN DESCRIPTION: RecName: Full=Actin-related protein 2; AltName: Full=Actin-like protein 2; FUNCTION: Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament. SUBUNIT: Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cell projection. SIMILARITY: Belongs to the actin family. ARP2 subfamily.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
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To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: ACTR2 Diseases sorted by gene-association score: wiskott-aldrich syndrome (7)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D003993 Dibutyl Phthalate D003300 Copper D004041 Dietary Fats D004997 Ethinyl Estradiol D005839 Gentamicins D011078 Polychlorinated Biphenyls D011692 Puromycin Aminonucleoside D013629 Tamoxifen D013749 Tetrachlorodibenzodioxin D013806 Theophylline D014501 Uranium C044887 beta-methylcholine C018021 cobaltous chloride C056933 fumonisin B1 C119536 nickel acetate C014707 nitrosobenzylmethylamine C006253 pirinixic acid C089032 rimonabant C005460 uranyl acetate C025643 vinclozolin

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 141.38 RPKM in Cells - EBV-transformed lymphocytes Total median expression: 1929.39 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-29.40	79	-0.372	Picture	PostScript	Text
3' UTR	-606.00	2519	-0.241	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR004000 - Actin-like
IPR020902 - Actin/actin-like_CS

Pfam Domains:
PF00022 - Actin

SCOP Domains:
53067 - Actin-like ATPase domain

ModBase Predicted Comparative 3D Structure on P61160


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	Genome Browser	Genome Browser
Gene Details	Gene Details		Gene Details	Gene Details	Gene Details
Gene Sorter	Gene Sorter		Gene Sorter	Gene Sorter	Gene Sorter
	RGD	Ensembl		WormBase	SGD
				Protein Sequence	Protein Sequence
				Alignment	Alignment

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0000166 nucleotide binding GO:0003779 actin binding GO:0005200 structural constituent of cytoskeleton GO:0005524 ATP binding GO:0008092 cytoskeletal protein binding GO:0051015 actin filament binding Biological Process: GO:0007015 actin filament organization GO:0007163 establishment or maintenance of cell polarity GO:0008306 associative learning GO:0008356 asymmetric cell division GO:0016344 meiotic chromosome movement towards spindle pole GO:0016482 cytosolic transport GO:0030036 actin cytoskeleton organization GO:0033206 meiotic cytokinesis GO:0034314 Arp2/3 complex-mediated actin nucleation GO:0035902 response to immobilization stress GO:0035984 cellular response to trichostatin A GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis GO:0043312 neutrophil degranulation GO:0045471 response to ethanol GO:0048013 ephrin receptor signaling pathway GO:0051321 meiotic cell cycle GO:0051653 spindle localization GO:0060271 cilium assembly GO:0061003 positive regulation of dendritic spine morphogenesis GO:0061024 membrane organization GO:0071346 cellular response to interferon-gamma Cellular Component: GO:0005576 extracellular region GO:0005737 cytoplasm GO:0005829 cytosol GO:0005856 cytoskeleton GO:0005885 Arp2/3 protein complex GO:0005925 focal adhesion GO:0005938 cell cortex GO:0014069 postsynaptic density GO:0015629 actin cytoskeleton GO:0016020 membrane GO:0030027 lamellipodium GO:0030478 actin cap GO:0035578 azurophil granule lumen GO:0042995 cell projection GO:0070062 extracellular exosome GO:0071437 invadopodium GO:1904813 ficolin-1-rich granule lumen

Descriptions from all associated GenBank mRNAs


	LF384713 - JP 2014500723-A/192216: Polycomb-Associated Non-Coding RNAs. AK295157 - Homo sapiens cDNA FLJ51656 complete cds, highly similar to Actin-like protein 2. AK301634 - Homo sapiens cDNA FLJ51655 complete cds, highly similar to Actin-like protein 2. BC014546 - Homo sapiens ARP2 actin-related protein 2 homolog (yeast), mRNA (cDNA clone MGC:13545 IMAGE:4247021), complete cds. BX649080 - Homo sapiens mRNA; cDNA DKFZp779L0756 (from clone DKFZp779L0756). AF006082 - Homo sapiens actin-related protein Arp2 (ARP2) mRNA, complete cds. AK315205 - Homo sapiens cDNA, FLJ96195, Homo sapiens ARP2 actin-related protein 2 homolog (yeast) (ACTR2),mRNA. JD211287 - Sequence 192311 from Patent EP1572962. LF325065 - JP 2014500723-A/132568: Polycomb-Associated Non-Coding RNAs. JD139463 - Sequence 120487 from Patent EP1572962. AB462954 - Synthetic construct DNA, clone: pF1KB4662, Homo sapiens ACTR2 gene for ARP2 actin-related protein 2 homolog, without stop codon, in Flexi system. EU832071 - Synthetic construct Homo sapiens clone HAIB:100067100; DKFZo004G0724 ARP2 actin-related protein 2 homolog (yeast) protein (ACTR2) gene, encodes complete protein. EU831978 - Synthetic construct Homo sapiens clone HAIB:100067007; DKFZo008G0723 ARP2 actin-related protein 2 homolog (yeast) protein (ACTR2) gene, encodes complete protein. BC036253 - Homo sapiens ARP2 actin-related protein 2 homolog (yeast), mRNA (cDNA clone MGC:43532 IMAGE:5268748), complete cds. LF366748 - JP 2014500723-A/174251: Polycomb-Associated Non-Coding RNAs. LF325055 - JP 2014500723-A/132558: Polycomb-Associated Non-Coding RNAs. LF325054 - JP 2014500723-A/132557: Polycomb-Associated Non-Coding RNAs. LF325051 - JP 2014500723-A/132554: Polycomb-Associated Non-Coding RNAs. LF325050 - JP 2014500723-A/132553: Polycomb-Associated Non-Coding RNAs. LF325049 - JP 2014500723-A/132552: Polycomb-Associated Non-Coding RNAs. JD019449 - Sequence 473 from Patent EP1572962. JD033672 - Sequence 14696 from Patent EP1572962. JD026750 - Sequence 7774 from Patent EP1572962. JD428859 - Sequence 409883 from Patent EP1572962. JD429536 - Sequence 410560 from Patent EP1572962. JD221324 - Sequence 202348 from Patent EP1572962. JD507479 - Sequence 488503 from Patent EP1572962. LF325047 - JP 2014500723-A/132550: Polycomb-Associated Non-Coding RNAs. JD422850 - Sequence 403874 from Patent EP1572962. LF325046 - JP 2014500723-A/132549: Polycomb-Associated Non-Coding RNAs. LF325045 - JP 2014500723-A/132548: Polycomb-Associated Non-Coding RNAs. LF325044 - JP 2014500723-A/132547: Polycomb-Associated Non-Coding RNAs. JD358320 - Sequence 339344 from Patent EP1572962. JD068065 - Sequence 49089 from Patent EP1572962. LF325043 - JP 2014500723-A/132546: Polycomb-Associated Non-Coding RNAs. LF325042 - JP 2014500723-A/132545: Polycomb-Associated Non-Coding RNAs. AL049356 - Homo sapiens mRNA; cDNA DKFZp566E233 (from clone DKFZp566E233). LF325041 - JP 2014500723-A/132544: Polycomb-Associated Non-Coding RNAs. AB462501 - Homo sapiens TVAS2 mRNA, PBMC-based diagnostic gene marker for vasculitis. LF325040 - JP 2014500723-A/132543: Polycomb-Associated Non-Coding RNAs. LF325039 - JP 2014500723-A/132542: Polycomb-Associated Non-Coding RNAs. MA620290 - JP 2018138019-A/192216: Polycomb-Associated Non-Coding RNAs. MA560642 - JP 2018138019-A/132568: Polycomb-Associated Non-Coding RNAs. MA602325 - JP 2018138019-A/174251: Polycomb-Associated Non-Coding RNAs. MA560632 - JP 2018138019-A/132558: Polycomb-Associated Non-Coding RNAs. MA560631 - JP 2018138019-A/132557: Polycomb-Associated Non-Coding RNAs. MA560628 - JP 2018138019-A/132554: Polycomb-Associated Non-Coding RNAs. MA560627 - JP 2018138019-A/132553: Polycomb-Associated Non-Coding RNAs. MA560626 - JP 2018138019-A/132552: Polycomb-Associated Non-Coding RNAs. MA560624 - JP 2018138019-A/132550: Polycomb-Associated Non-Coding RNAs. MA560623 - JP 2018138019-A/132549: Polycomb-Associated Non-Coding RNAs. MA560622 - JP 2018138019-A/132548: Polycomb-Associated Non-Coding RNAs. MA560621 - JP 2018138019-A/132547: Polycomb-Associated Non-Coding RNAs. MA560620 - JP 2018138019-A/132546: Polycomb-Associated Non-Coding RNAs. MA560619 - JP 2018138019-A/132545: Polycomb-Associated Non-Coding RNAs. MA560618 - JP 2018138019-A/132544: Polycomb-Associated Non-Coding RNAs. MA560617 - JP 2018138019-A/132543: Polycomb-Associated Non-Coding RNAs. MA560616 - JP 2018138019-A/132542: Polycomb-Associated Non-Coding RNAs.

Biochemical and Signaling Pathways


	Reactome (by CSHL, EBI, and GO) Protein P61160 (Reactome details) participates in the following event(s): R-HSA-6798751 Exocytosis of azurophil granule lumen proteins R-HSA-6800434 Exocytosis of ficolin-rich granule lumen proteins R-HSA-442592 WASPs or WAVEs activate the ARP2/3 complex R-HSA-3928595 N-WASP binds ARP2/3 and G-actin R-HSA-8868230 SNX9 recruits components of the actin polymerizing machinery R-HSA-2029466 Attachment of preexisting mother filament and initiation of branching R-HSA-1861595 Extension of pseudopodia by myosin-X in a PI3K dependent manner R-HSA-2197690 Detachment of WASP/WAVE R-HSA-8868236 BAR domain proteins recruit dynamin R-HSA-8871194 RAB5 and GAPVD1 bind AP-2 R-HSA-8868658 HSPA8-mediated ATP hydrolysis promotes vesicle uncoating R-HSA-8868659 Clathrin recruits auxilins to the clathrin-coated vesicle R-HSA-8868661 Dynamin-mediated GTP hydrolysis promotes vesicle scission R-HSA-8868660 Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle R-HSA-8868648 SYNJ hydrolyze PI(4,5)P2 to PI(4)P R-HSA-8868651 Endophilins recruit synaptojanins to the clathrin-coated pit R-HSA-6798695 Neutrophil degranulation R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation R-HSA-5663213 RHO GTPases Activate WASPs and WAVEs R-HSA-3928662 EPHB-mediated forward signaling R-HSA-8856828 Clathrin-mediated endocytosis R-HSA-168249 Innate Immune System R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-195258 RHO GTPase Effectors R-HSA-2682334 EPH-Ephrin signaling R-HSA-199991 Membrane Trafficking R-HSA-168256 Immune System R-HSA-194315 Signaling by Rho GTPases R-HSA-422475 Axon guidance R-HSA-5653656 Vesicle-mediated transport R-HSA-162582 Signal Transduction R-HSA-1266738 Developmental Biology

Other Names for This Gene


	Alternate Gene Symbols: ARP2, ARP2_HUMAN, B2RCP5, D6W5F4, E9PF41, ENST00000260641.1, ENST00000260641.2, ENST00000260641.3, ENST00000260641.4, ENST00000260641.5, ENST00000260641.6, ENST00000260641.7, ENST00000260641.8, ENST00000260641.9, NM_005722, O15142, P61160, Q96C82, uc317gld.1, uc317gld.2 UCSC ID: ENST00000260641.10_12 RefSeq Accession: NM_005722.4 Protein: P61160 (aka ARP2_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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