Human Gene ACTR1B (ENST00000289228.7_7) from GENCODE V47lift37
  Description: actin related protein 1B (from RefSeq NM_005735.4)
Gencode Transcript: ENST00000289228.7_7
Gencode Gene: ENSG00000115073.8_9
Transcript (Including UTRs)
   Position: hg19 chr2:98,272,402-98,280,507 Size: 8,106 Total Exon Count: 11 Strand: -
Coding Region
   Position: hg19 chr2:98,273,321-98,280,353 Size: 7,033 Coding Exon Count: 11 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:98,272,402-98,280,507)mRNA (may differ from genome)Protein (376 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MGIOMIMPubMedReactomeUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ACTY_HUMAN
DESCRIPTION: RecName: Full=Beta-centractin; AltName: Full=Actin-related protein 1B; Short=ARP1B;
FUNCTION: Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome.
INTERACTION: Q9QZB7:Actr10 (xeno); NbExp=2; IntAct=EBI-367493, EBI-367600;
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, centrosome.
SIMILARITY: Belongs to the actin family. ARP1 subfamily.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 73.02 RPKM in Brain - Cortex
Total median expression: 2059.46 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -86.60154-0.562 Picture PostScript Text
3' UTR -383.00919-0.417 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR004000 - Actin-like
IPR020902 - Actin/actin-like_CS
IPR004001 - Actin_CS

Pfam Domains:
PF00022 - Actin

SCOP Domains:
53067 - Actin-like ATPase domain

ModBase Predicted Comparative 3D Structure on P42025
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0005515 protein binding
GO:0005524 ATP binding

Biological Process:
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0043312 neutrophil degranulation

Cellular Component:
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005815 microtubule organizing center
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005869 dynactin complex
GO:0015630 microtubule cytoskeleton
GO:0016020 membrane
GO:0034774 secretory granule lumen
GO:0070062 extracellular exosome
GO:1904813 ficolin-1-rich granule lumen


-  Descriptions from all associated GenBank mRNAs
  LF205182 - JP 2014500723-A/12685: Polycomb-Associated Non-Coding RNAs.
X82207 - H.sapiens mRNA for beta-centractin (PC3).
BC006372 - Homo sapiens ARP1 actin-related protein 1 homolog B, centractin beta (yeast), mRNA (cDNA clone MGC:12805 IMAGE:4138683), complete cds.
BC004374 - Homo sapiens ARP1 actin-related protein 1 homolog B, centractin beta (yeast), mRNA (cDNA clone MGC:10568 IMAGE:3638252), complete cds.
BC010090 - Homo sapiens ARP1 actin-related protein 1 homolog B, centractin beta (yeast), mRNA (cDNA clone MGC:19650 IMAGE:2989545), complete cds.
BC025274 - Homo sapiens ARP1 actin-related protein 1 homolog B, centractin beta (yeast), mRNA (cDNA clone IMAGE:4648147).
JD237727 - Sequence 218751 from Patent EP1572962.
LF317353 - JP 2014500723-A/124856: Polycomb-Associated Non-Coding RNAs.
JD101599 - Sequence 82623 from Patent EP1572962.
JD163079 - Sequence 144103 from Patent EP1572962.
JD212039 - Sequence 193063 from Patent EP1572962.
JD162882 - Sequence 143906 from Patent EP1572962.
JD075824 - Sequence 56848 from Patent EP1572962.
JD122082 - Sequence 103106 from Patent EP1572962.
JD221798 - Sequence 202822 from Patent EP1572962.
JD253030 - Sequence 234054 from Patent EP1572962.
JD485810 - Sequence 466834 from Patent EP1572962.
JD279270 - Sequence 260294 from Patent EP1572962.
JD050519 - Sequence 31543 from Patent EP1572962.
JD104621 - Sequence 85645 from Patent EP1572962.
JD283691 - Sequence 264715 from Patent EP1572962.
JD223844 - Sequence 204868 from Patent EP1572962.
JD279396 - Sequence 260420 from Patent EP1572962.
JD104058 - Sequence 85082 from Patent EP1572962.
JD225163 - Sequence 206187 from Patent EP1572962.
JD086005 - Sequence 67029 from Patent EP1572962.
JD355058 - Sequence 336082 from Patent EP1572962.
JD053226 - Sequence 34250 from Patent EP1572962.
JD470222 - Sequence 451246 from Patent EP1572962.
JD392043 - Sequence 373067 from Patent EP1572962.
JD392667 - Sequence 373691 from Patent EP1572962.
JD445991 - Sequence 427015 from Patent EP1572962.
JD561241 - Sequence 542265 from Patent EP1572962.
JD550546 - Sequence 531570 from Patent EP1572962.
JD484533 - Sequence 465557 from Patent EP1572962.
JD211433 - Sequence 192457 from Patent EP1572962.
LF317356 - JP 2014500723-A/124859: Polycomb-Associated Non-Coding RNAs.
DQ893438 - Synthetic construct clone IMAGE:100006068; FLH199529.01X; RZPDo839H0282D ARP1 actin-related protein 1 homolog B, centractin beta (yeast) (ACTR1B) gene, encodes complete protein.
KJ898160 - Synthetic construct Homo sapiens clone ccsbBroadEn_07554 ACTR1B gene, encodes complete protein.
KJ898161 - Synthetic construct Homo sapiens clone ccsbBroadEn_07555 ACTR1B gene, encodes complete protein.
DQ896748 - Synthetic construct Homo sapiens clone IMAGE:100011208; FLH199436.01L; RZPDo839H0281D ARP1 actin-related protein 1 homolog B, centractin beta (yeast) (ACTR1B) gene, encodes complete protein.
AB528334 - Synthetic construct DNA, clone: pF1KB5462, Homo sapiens ACTR1B gene for ARP1 actin-related protein 1 homolog B, centractin beta, without stop codon, in Flexi system.
X82208 - H.sapiens mRNA for beta-centractin (ATCC# HHCPJ76).
CU678694 - Synthetic construct Homo sapiens gateway clone IMAGE:100023428 5' read ACTR1B mRNA.
LF317357 - JP 2014500723-A/124860: Polycomb-Associated Non-Coding RNAs.
LF317358 - JP 2014500723-A/124861: Polycomb-Associated Non-Coding RNAs.
MA440759 - JP 2018138019-A/12685: Polycomb-Associated Non-Coding RNAs.
MA552930 - JP 2018138019-A/124856: Polycomb-Associated Non-Coding RNAs.
MA552933 - JP 2018138019-A/124859: Polycomb-Associated Non-Coding RNAs.
MA552934 - JP 2018138019-A/124860: Polycomb-Associated Non-Coding RNAs.
MA552935 - JP 2018138019-A/124861: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P42025 (Reactome details) participates in the following event(s):

R-HSA-6800434 Exocytosis of ficolin-rich granule lumen proteins
R-HSA-6798748 Exocytosis of secretory granule lumen proteins
R-HSA-2132295 MHC class II antigen presentation
R-HSA-6798695 Neutrophil degranulation
R-HSA-1280218 Adaptive Immune System
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: ACTY_HUMAN, CTRN2, D3DVH2, ENST00000289228.1, ENST00000289228.2, ENST00000289228.3, ENST00000289228.4, ENST00000289228.5, ENST00000289228.6, NM_005735, P42025, Q53SK5, Q9BRB7, uc317krl.1, uc317krl.2
UCSC ID: ENST00000289228.7_7
RefSeq Accession: NM_005735.4
Protein: P42025 (aka ACTY_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.