Human Gene ACAD11 (ENST00000264990.11_7) from GENCODE V47lift37
  Description: acyl-CoA dehydrogenase family member 11, transcript variant 1 (from RefSeq NM_032169.5)
Gencode Transcript: ENST00000264990.11_7
Gencode Gene: ENSG00000240303.8_10
Transcript (Including UTRs)
   Position: hg19 chr3:132,276,985-132,378,653 Size: 101,669 Total Exon Count: 20 Strand: -
Coding Region
   Position: hg19 chr3:132,277,815-132,378,595 Size: 100,781 Coding Exon Count: 20 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:132,276,985-132,378,653)mRNA (may differ from genome)Protein (780 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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UniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ACD11_HUMAN
DESCRIPTION: RecName: Full=Acyl-CoA dehydrogenase family member 11; Short=ACAD-11; EC=1.3.99.-;
FUNCTION: Acyl-CoA dehydrogenase, that exhibits maximal activity towards saturated C22-CoA.
CATALYTIC ACTIVITY: Acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor.
COFACTOR: FAD.
SUBUNIT: Homodimer.
SUBCELLULAR LOCATION: Peroxisome (By similarity). Mitochondrion. Note=Has been detected associated with mitochondrial membrane, but no matrix, in kidney and cerebellum, as well as in a neuroblastoma cell line, but not in skin fibroblasts, where it is observed in cytoplasmic vesicles (PubMed:21237683). No mitochondrial targeting signals could be predicted for any known isoform, including a putative isoform starting at Met-316.
TISSUE SPECIFICITY: Widely expressed with highest levels in brain followed by liver, heart and kidney.
SIMILARITY: Belongs to the acyl-CoA dehydrogenase family.
SEQUENCE CAUTION: Sequence=BAB14158.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: ACAD11
Diseases sorted by gene-association score: nephronophthisis 3 (6)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.00 RPKM in (null)
Total median expression: 0.00 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -19.0058-0.328 Picture PostScript Text
3' UTR -230.60830-0.278 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR006092 - Acyl-CoA_DH_N
IPR006090 - Acyl-CoA_Oxase/DH_1
IPR006091 - Acyl-CoA_Oxase/DH_cen-dom
IPR009075 - AcylCo_DH/oxidase_C
IPR013786 - AcylCoA_DH/ox_N
IPR009100 - AcylCoA_DH/oxidase
IPR002575 - Aminoglycoside_PTrfase
IPR011009 - Kinase-like_dom

Pfam Domains:
PF00441 - Acyl-CoA dehydrogenase, C-terminal domain
PF01636 - Phosphotransferase enzyme family
PF02770 - Acyl-CoA dehydrogenase, middle domain
PF02771 - Acyl-CoA dehydrogenase, N-terminal domain
PF08028 - Acyl-CoA dehydrogenase, C-terminal domain

SCOP Domains:
47203 - Acyl-CoA dehydrogenase C-terminal domain-like
56112 - Protein kinase-like (PK-like)
56645 - Acyl-CoA dehydrogenase NM domain-like

Protein Data Bank (PDB) 3-D Structure
MuPIT help
2WBI - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on Q709F0
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003995 acyl-CoA dehydrogenase activity
GO:0004466 long-chain-acyl-CoA dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors
GO:0017099 very-long-chain-acyl-CoA dehydrogenase activity
GO:0050660 flavin adenine dinucleotide binding
GO:0070991 medium-chain-acyl-CoA dehydrogenase activity

Biological Process:
GO:0006635 fatty acid beta-oxidation
GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase
GO:0055114 oxidation-reduction process

Cellular Component:
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005777 peroxisome
GO:0031966 mitochondrial membrane


-  Descriptions from all associated GenBank mRNAs
  AB082531 - Homo sapiens mRNA for KIAA2000 protein.
AY257867 - Homo sapiens nephrocystin 3 splice variant (NPHP3) mRNA, partial cds.
BC019607 - Homo sapiens acyl-Coenzyme A dehydrogenase family, member 11, mRNA (cDNA clone IMAGE:3457449), partial cds.
AL833721 - Homo sapiens mRNA; cDNA DKFZp666D245 (from clone DKFZp666D245).
JD236502 - Sequence 217526 from Patent EP1572962.
JD261620 - Sequence 242644 from Patent EP1572962.
BC125204 - Homo sapiens acyl-Coenzyme A dehydrogenase family, member 11, mRNA (cDNA clone MGC:150619 IMAGE:40123454), complete cds.
BC125205 - Homo sapiens acyl-Coenzyme A dehydrogenase family, member 11, mRNA (cDNA clone IMAGE:40123455), complete cds.
JD518030 - Sequence 499054 from Patent EP1572962.
AK022654 - Homo sapiens cDNA FLJ12592 fis, clone NT2RM4001316, weakly similar to ACYL-COA DEHYDROGENASE, MEDIUM-CHAIN SPECIFIC PRECURSOR (EC 1.3.99.3).
AX803783 - Sequence 1 from Patent EP1331227.
AJ608287 - Homo sapiens mRNA for putative acyl-CoA dehydrogenase.
JD460082 - Sequence 441106 from Patent EP1572962.
JD541497 - Sequence 522521 from Patent EP1572962.
JD106063 - Sequence 87087 from Patent EP1572962.
JD518029 - Sequence 499053 from Patent EP1572962.
JD149471 - Sequence 130495 from Patent EP1572962.
JD257588 - Sequence 238612 from Patent EP1572962.
JD351995 - Sequence 333019 from Patent EP1572962.
JD448427 - Sequence 429451 from Patent EP1572962.
JD267593 - Sequence 248617 from Patent EP1572962.
JD229014 - Sequence 210038 from Patent EP1572962.
JD281631 - Sequence 262655 from Patent EP1572962.
JD508492 - Sequence 489516 from Patent EP1572962.
AK131265 - Homo sapiens cDNA FLJ16200 fis, clone CTONG2004000.
JD117092 - Sequence 98116 from Patent EP1572962.
JD339118 - Sequence 320142 from Patent EP1572962.
JD043142 - Sequence 24166 from Patent EP1572962.
JD441432 - Sequence 422456 from Patent EP1572962.
JD287987 - Sequence 269011 from Patent EP1572962.
JD340775 - Sequence 321799 from Patent EP1572962.
JD291598 - Sequence 272622 from Patent EP1572962.
JD431206 - Sequence 412230 from Patent EP1572962.
JD512213 - Sequence 493237 from Patent EP1572962.
JD428548 - Sequence 409572 from Patent EP1572962.
JD373821 - Sequence 354845 from Patent EP1572962.
JD553466 - Sequence 534490 from Patent EP1572962.
AL832873 - Homo sapiens mRNA; cDNA DKFZp667H103 (from clone DKFZp667H103).
JD497011 - Sequence 478035 from Patent EP1572962.
JD220472 - Sequence 201496 from Patent EP1572962.
KJ906357 - Synthetic construct Homo sapiens clone ccsbBroadEn_16027 ACAD11 gene, encodes complete protein.
AX803785 - Sequence 3 from Patent EP1331227.
KJ894938 - Synthetic construct Homo sapiens clone ccsbBroadEn_04332 ACAD11 gene, encodes complete protein.
CU676448 - Synthetic construct Homo sapiens gateway clone IMAGE:100019212 5' read ACAD11 mRNA.
AK298627 - Homo sapiens cDNA FLJ59005 complete cds, highly similar to Homo sapiens acyl-CoA dehydrogenase, mRNA.
AK308380 - Homo sapiens cDNA, FLJ98328.
JD188400 - Sequence 169424 from Patent EP1572962.
JD280245 - Sequence 261269 from Patent EP1572962.
JD435843 - Sequence 416867 from Patent EP1572962.
JD182136 - Sequence 163160 from Patent EP1572962.
JD468382 - Sequence 449406 from Patent EP1572962.
JD300029 - Sequence 281053 from Patent EP1572962.
JD466995 - Sequence 448019 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q709F0 (Reactome details) participates in the following event(s):

R-HSA-5695989 ACAD11 dehydrogenates BH-CoA
R-HSA-77289 Mitochondrial Fatty Acid Beta-Oxidation
R-HSA-8978868 Fatty acid metabolism
R-HSA-556833 Metabolism of lipids
R-HSA-1430728 Metabolism

-  Other Names for This Gene
  Alternate Gene Symbols: ACD11_HUMAN, ENST00000264990.1, ENST00000264990.10, ENST00000264990.2, ENST00000264990.3, ENST00000264990.4, ENST00000264990.5, ENST00000264990.6, ENST00000264990.7, ENST00000264990.8, ENST00000264990.9, NM_032169, Q08AF0, Q658N9, Q658Y2, Q6ZND2, Q709F0, Q8WUT6, Q9H9R3, uc317hxh.1, uc317hxh.2
UCSC ID: ENST00000264990.11_7
RefSeq Accession: NM_032169.5
Protein: Q709F0 (aka ACD11_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.