ID:ABCD3_HUMAN DESCRIPTION: RecName: Full=ATP-binding cassette sub-family D member 3; AltName: Full=70 kDa peroxisomal membrane protein; Short=PMP70; FUNCTION: Probable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity. SUBUNIT: Can form heterodimers with ABCD1/ALD and ABCD2/ALDR. Dimerization is necessary to form an active transporter. Interacts with PEX19. INTERACTION: P33897:ABCD1; NbExp=2; IntAct=EBI-80992, EBI-81045; P40855:PEX19; NbExp=2; IntAct=EBI-80992, EBI-594747; SUBCELLULAR LOCATION: Peroxisome membrane; Multi-pass membrane protein. MISCELLANEOUS: Mutation in ABCD3 have been found in two individuals affected by Zellweger syndrome. However, the role of ABCD3 in the causation of Zellweger syndrome remains uncertain. SIMILARITY: Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily. SIMILARITY: Contains 1 ABC transmembrane type-1 domain. SIMILARITY: Contains 1 ABC transporter domain. WEB RESOURCE: Name=ABCMdb; Note=Database for mutations in ABC proteins; URL="http://abcmutations.hegelab.org/proteinDetails?uniprot_id=P28288";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 52540 - P-loop containing nucleoside triphosphate hydrolases 53795 - PEP carboxykinase-like 90123 - ABC transporter transmembrane region
ModBase Predicted Comparative 3D Structure on P28288
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK296791 - Homo sapiens cDNA FLJ53353 complete cds, highly similar to ATP-binding cassette sub-family D member 3. AK302714 - Homo sapiens cDNA FLJ54042 complete cds, highly similar to ATP-binding cassette sub-family D member 3. AK308159 - Homo sapiens cDNA, FLJ98107. BC068509 - Homo sapiens ATP-binding cassette, sub-family D (ALD), member 3, mRNA (cDNA clone MGC:87282 IMAGE:5265201), complete cds. BC009712 - Homo sapiens ATP-binding cassette, sub-family D (ALD), member 3, mRNA (cDNA clone IMAGE:3895175), complete cds. X58528 - Human PMP70 mRNA for a peroxisomal membrane protein. AB529219 - Synthetic construct DNA, clone: pF1KB6181, Homo sapiens ABCD3 gene for ATP-binding cassette, sub-family D (ALD), member 3, without stop codon, in Flexi system. KJ905886 - Synthetic construct Homo sapiens clone ccsbBroadEn_15556 ABCD3 gene, encodes complete protein. CU679455 - Synthetic construct Homo sapiens gateway clone IMAGE:100016844 5' read ABCD3 mRNA. BT006644 - Homo sapiens ATP-binding cassette, sub-family D (ALD), member 3 mRNA, complete cds. M81182 - Homo sapiens peroxisomal 70 kD membrane protein mRNA, complete cds. JD407770 - Sequence 388794 from Patent EP1572962. BX648715 - Homo sapiens mRNA; cDNA DKFZp686E02117 (from clone DKFZp686E02117). AK126440 - Homo sapiens cDNA FLJ44476 fis, clone UTERU2031611. JD561827 - Sequence 542851 from Patent EP1572962. JD363071 - Sequence 344095 from Patent EP1572962. JD089711 - Sequence 70735 from Patent EP1572962. JD555949 - Sequence 536973 from Patent EP1572962. JD521824 - Sequence 502848 from Patent EP1572962. JD027401 - Sequence 8425 from Patent EP1572962. JD280340 - Sequence 261364 from Patent EP1572962. JD026633 - Sequence 7657 from Patent EP1572962. JD034370 - Sequence 15394 from Patent EP1572962. JD031269 - Sequence 12293 from Patent EP1572962. JD488864 - Sequence 469888 from Patent EP1572962. JD168178 - Sequence 149202 from Patent EP1572962.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_nuclearRsPathway - Nuclear Receptors in Lipid Metabolism and Toxicity
Reactome (by CSHL, EBI, and GO)
Protein P28288 (Reactome details) participates in the following event(s):
R-HSA-382613 PEX-19 docks ABCD1/D2/D3 to peroximal membrane R-HSA-382575 ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix R-HSA-1369062 ABC transporters in lipid homeostasis R-HSA-382556 ABC-family proteins mediated transport R-HSA-382551 Transport of small molecules
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
