The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 52540 - P-loop containing nucleoside triphosphate hydrolases 53795 - PEP carboxykinase-like 90123 - ABC transporter transmembrane region
ModBase Predicted Comparative 3D Structure on O15439
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000166 nucleotide binding GO:0005524 ATP binding GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GO:0016404 15-hydroxyprostaglandin dehydrogenase (NAD+) activity GO:0016887 ATPase activity GO:0042626 ATPase activity, coupled to transmembrane movement of substances GO:0043225 ATPase-coupled anion transmembrane transporter activity
Biological Process: GO:0002576 platelet degranulation GO:0008150 biological_process GO:0032310 prostaglandin secretion GO:0055085 transmembrane transport GO:0055114 oxidation-reduction process GO:0060271 cilium assembly GO:0099131 ATP hydrolysis coupled ion transmembrane transport GO:0099133 ATP hydrolysis coupled anion transmembrane transport
BX647118 - Homo sapiens mRNA; cDNA DKFZp686O08144 (from clone DKFZp686O08144). AY081219 - Homo sapiens multidrug resistance-associated protein (ABCC4) mRNA, complete cds. AK309460 - Homo sapiens cDNA, FLJ99501. AF071203 - Homo sapiens ABC transporter MOAT-B isoform (MOAT-B) mRNA, partial cds. AF071202 - Homo sapiens ABC transporter MOAT-B (MOAT-B) mRNA, complete cds. AF541977 - Homo sapiens ATP-binding cassette protein C4 splice variant A (ABCC4) mRNA, complete cds; alternatively spliced. AY207008 - Homo sapiens ATP-binding cassette transporter C4 (ABCC4) mRNA, complete cds. U83660 - Human multidrug resistance-associated protein homolog (MRP4) mRNA, partial cds. AK296247 - Homo sapiens cDNA FLJ52311 complete cds, highly similar to Multidrug resistance-associated protein 4. AK290317 - Homo sapiens cDNA FLJ77042 complete cds, highly similar to Homo sapiens ATP-binding cassette, sub-family C (CFTR/MRP), member 4, mRNA. BC041560 - Homo sapiens ATP-binding cassette, sub-family C (CFTR/MRP), member 4, mRNA (cDNA clone MGC:52221 IMAGE:5812052), complete cds. AB208973 - Homo sapiens mRNA for ABCC4 protein variant protein. AY133678 - Homo sapiens ATP-binding cassette subfamily C member 4 variant 2 (ABCC4) mRNA, complete cds, alternatively spliced. AY133679 - Homo sapiens ATP-binding cassette subfamily C member 4 variant 1 (ABCC4) mRNA, complete cds, alternatively spliced. AY133680 - Homo sapiens ATP-binding cassette subfamily C member 4 variant 3 (ABCC4) mRNA, complete cds, alternatively spliced. AK298953 - Homo sapiens cDNA FLJ58088 complete cds, highly similar to Multidrug resistance-associated protein 4. AF339763 - Homo sapiens clone IMAGE:1058325, mRNA sequence. JD555208 - Sequence 536232 from Patent EP1572962. U66686 - Homo sapiens clone EST205858 mRNA sequence. U66682 - Homo sapiens clone EST170205 mRNA sequence.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein O15439 (Reactome details) participates in the following event(s):
R-HSA-429157 ABCC4 accumulation of dense granule contents R-HSA-1454916 The ABCC family mediates organic anion transport R-HSA-114608 Platelet degranulation R-HSA-76005 Response to elevated platelet cytosolic Ca2+ R-HSA-382556 ABC-family proteins mediated transport R-HSA-76002 Platelet activation, signaling and aggregation R-HSA-382551 Transport of small molecules R-HSA-109582 Hemostasis
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
