ID:ADPPT_HUMAN DESCRIPTION: RecName: Full=L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase; EC=2.7.8.-; AltName: Full=4'-phosphopantetheinyl transferase; AltName: Full=Alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase; Short=AASD-PPT; AltName: Full=LYS5 ortholog; FUNCTION: Catalyzes the post-translational modification of target proteins by phosphopantetheine. Can transfer the 4'- phosphopantetheine moiety from coenzyme A to a serine residue of a broad range of acceptors, such as the acyl carrier domain of FASN. CATALYTIC ACTIVITY: CoA-[4'-phosphopantetheine] + apo-[acyl- carrier-protein] = adenosine 3',5'-bisphosphate + holo-[acyl- carrier-protein]. COFACTOR: Binds 1 magnesium ion. BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=0.44 mM for magnesium; KM=0.025 mM for coenzyme A; SUBUNIT: Monomer. Interacts with FASN. SUBCELLULAR LOCATION: Cytoplasm. TISSUE SPECIFICITY: Detected in heart, skeletal muscle, placenta, testis, brain, pancreas, liver and kidney. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Belongs to the P-Pant transferase superfamily. AcpS family. SEQUENCE CAUTION: Sequence=AAD34075.1; Type=Frameshift; Positions=34, 63; Sequence=AAF86879.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9NRN7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AF151057 - Homo sapiens HSPC223 mRNA, complete cds. AF136978 - Homo sapiens proteinx0005 mRNA, complete cds. AF151838 - Homo sapiens CGI-80 protein mRNA, complete cds. AF302110 - Homo sapiens alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase mRNA, complete cds. AF201943 - Homo sapiens HAH-P (HAH-P) mRNA, complete cds. BC016728 - Homo sapiens aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase, mRNA (cDNA clone MGC:24460 IMAGE:4081713), complete cds. AK312529 - Homo sapiens cDNA, FLJ92898, Homo sapiens aminoadipate-semialdehydedehydrogenase-phosphopantetheinyl transferase (AASDHPPT), mRNA. BC015470 - Homo sapiens aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase, mRNA (cDNA clone MGC:8777 IMAGE:3914010), complete cds. AK293362 - Homo sapiens cDNA FLJ57947 complete cds, highly similar to L-aminoadipate-semialdehydedehydrogenase-phosphopantetheinyl transferase (EC 2.7.8.-). JD288214 - Sequence 269238 from Patent EP1572962. CU677695 - Synthetic construct Homo sapiens gateway clone IMAGE:100017005 5' read AASDHPPT mRNA. AB463408 - Synthetic construct DNA, clone: pF1KB6421, Homo sapiens AASDHPPT gene for aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase, without stop codon, in Flexi system. DQ891342 - Synthetic construct clone IMAGE:100003972; FLH171239.01X; RZPDo839G02100D aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase (AASDHPPT) gene, encodes complete protein. DQ894524 - Synthetic construct Homo sapiens clone IMAGE:100008984; FLH171235.01L; RZPDo839G0299D aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase (AASDHPPT) gene, encodes complete protein. KJ894497 - Synthetic construct Homo sapiens clone ccsbBroadEn_03891 AASDHPPT gene, encodes complete protein. KJ899406 - Synthetic construct Homo sapiens clone ccsbBroadEn_08800 AASDHPPT gene, encodes complete protein. AL050073 - Homo sapiens mRNA; cDNA DKFZp566E2346 (from clone DKFZp566E2346); partial cds. BX537665 - Homo sapiens mRNA; cDNA DKFZp686B1090 (from clone DKFZp686B1090). AB072896 - Homo sapiens primary neuroblastoma cDNA, clone:Nbla10830. JD203143 - Sequence 184167 from Patent EP1572962. JD195253 - Sequence 176277 from Patent EP1572962. JD386409 - Sequence 367433 from Patent EP1572962. JD053398 - Sequence 34422 from Patent EP1572962. JD171940 - Sequence 152964 from Patent EP1572962. JD286080 - Sequence 267104 from Patent EP1572962. JD281108 - Sequence 262132 from Patent EP1572962.
Biochemical and Signaling Pathways
BioCyc Knowledge Library PWY-6012-1 - acyl carrier protein activation
Reactome (by CSHL, EBI, and GO)
Protein Q9NRN7 (Reactome details) participates in the following event(s):
R-HSA-199202 Phosphopantetheine conjugation of the ACP domain of FAS R-HSA-199220 Vitamin B5 (pantothenate) metabolism R-HSA-196849 Metabolism of water-soluble vitamins and cofactors R-HSA-196854 Metabolism of vitamins and cofactors R-HSA-1430728 Metabolism
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
