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GATA3 — IL13
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Kishikawa et al., J Immunol 2001
:
The cell type-specific expression of the murine
IL-13 gene is
regulated by
GATA-3
Lavenu-Bombled et al., J Biol Chem 2002
:
Interleukin-13 gene expression is
regulated by
GATA-3 in T cells : role of a critical association of a GATA and two GATG motifs ...
Interleukin-13 gene expression is
regulated by GATA-3 in T cells : role of a critical association of a
GATA and two GATG motifs ... Because
IL-13 gene expression was highly
enhanced in vivo by
GATA-3 expression, we studied the human and the mouse IL-13 gene promoters and found an evolutionary conserved association of a consensus GATA binding site and two GATG motifs
Takemoto et al., J Immunol 2002
:
The selective use of the N-finger may underlie the differential
roles of
GATA-3 in the induction of IL-4,
IL-13 , and IL-5
Masuda et al., J Immunol 2004
:
In T cells,
involvement of
GATA-3 in cell type-specific expression of the
IL-13 gene has been reported
Kitamura et al., Immunol Cell Biol 2005
(Hypersensitivity) :
A reduction of GATA-3 using RNA interference technology suppressed, whereas overexpression of
GATA-3 enhanced , the expression of IL-3 and
IL-13
Wang et al., J Immunol 2006
:
GATA-3 strongly
activated IL-4, IL-5, and
IL-13 expression in conventional T cells but had comparatively weak effects on these cytokines in NKT cells
Zhao et al., J Immunol 2007
(Leishmaniasis, Cutaneous) :
Mechanistically, Pias1 markedly potentiated
GATA-3 mediated activation of the
IL-13 promoter by facilitating the recruitment of GATA-3 to the promoter
Barnes et al., Curr Mol Med 2008
(Asthma...) :
In addition
GATA-3 is
essential for the gene expression of the cytokines IL-4, IL-5 and
IL-13 that mediate allergic inflammation
Notani et al., PLoS Biol 2010
:
In the presence of Dickkopf 1 (Dkk1), an inhibitor of Wnt signalling,
GATA-3 is downregulated and the expression of signature T ( H ) 2 cytokines such as IL-4, IL-10, and
IL-13 is
reduced , indicating that Wnt signalling is essential for T ( H ) 2 differentiation
Yao et al., Chin Med J (Engl) 2010
:
Small interference RNA ( siRNA ) was constructed to knock down GATA3 expression in Hut-78 cells to investigate the possible
role of
GATA3-NFAT1 complex in
IL-13 transcription ...
GATA3-NFAT1 complex may
play an important role in the regulation of
IL-13 transcription in human T cells
Fuschiotti et al., Cytokine 2011
(Scleroderma, Systemic) :
Silencing of
GATA-3 with siRNA significantly
reduces IL-13 production by CD8+ T cells from patients
Kozuka et al., J Immunol 2011
:
c-Myb and
GATA-3 cooperatively
regulate IL-13 expression via conserved GATA-3 response element and recruit mixed lineage leukemia (MLL) for histone modification of the IL-13 locus ... In this article, we report that c-Myb and
GATA-3 cooperatively
play an essential role in
IL-13 expression though direct binding to a conserved GATA-3 response element ( CGRE ), an enhancer for IL-13 expression ... c-Myb and
GATA-3 were shown to
activate the
CGRE-IL-13 promoter by ~160-fold, and mutation of the canonical Myb binding site completely abrogated CGRE enhancer activity
Liang et al., Nat Immunol 2012
(Hypersensitivity...) :
IL-13 production by T ( H ) 2 and Ih2 cells was
dependent on the transcription factor
GATA-3 , which was present in large amounts in these cells, and in contrast to the small amount of GATA-3 in T ( FH ) cells and basophils