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CDH13 — GSK3B
Text-mined interactions from Literome
Demarchi et al., J Biol Chem 2003
:
Glycogen synthase kinase-3 beta regulates NF-kappa
B1/p105 stability
Joshi et al., FASEB J 2007
:
ILK-siRNA abolished
T-cad dependent effects on ( Ser-473 ) Akt/ ( Ser-9 )
GSK3beta phosphorylation, active beta-catenin accumulation, and survival
Farina et al., PloS one 2009
(Breast Neoplasms...) :
Here we show that cell density and
GSK-3beta regulate
cadherin-11 levels in cancer cells ... Our data show that
GSK3beta regulates
cadherin-11 expression in two ways : first a beta-catenin independent regulation of cadherin-11 steady state mRNA levels, and second a beta-catenin dependent effect on cadherin-11 3'UTR stability and protein translation
Joshi et al., FASEB J 2009
:
Similarly to overexpression of native T-cad, cells expressing DeltaII, DeltaIII, or DeltaIV displayed elevated levels of p-Akt and p-GSK3beta and increased proliferation rates ( for DeltaII, DeltaIII ) vs. E. DeltaI- and DeltaV transduced cells exhibited reduced levels of p-Akt and p-GSK3beta and retarded growth rates vs. E. Stimulatory
effects of native
T-cad overexpression on Akt and
GSK3beta phosphorylation were dose dependently inhibited by coexpression of DeltaI or DeltaV