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CREBBP — ESR2
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Labrie et al., J Steroid Biochem Mol Biol 1999
(Breast Neoplasms...) :
Most importantly, the antiestrogen hydroxytamoxifen has no inhibitory effect on the
SRC-1 induced
ER beta activity while the pure antiestrogen EM-652 completely abolishes this effect, thus strengthening the need to use pure antiestrogens in breast cancer therapy in order to control all known aspects of ER-regulated gene expression
Hartmaier et al., Mol Endocrinol 2012
(Bone Demineralization, Pathologic...) :
The coregulator steroid receptor coactivator
(SRC)-1 increases transcriptional activity of the
estrogen receptor ( ER ) in a number of tissues including bone
Sanchez et al., Oncogene 2013
:
Coordinate
regulation of
estrogen receptor ß degradation by Mdm2 and
CREB binding protein in response to growth signals
Tremblay et al., Mol Endocrinol 1997
:
Moreover, the ligand independent stimulatory
effect of
SRC-1 on
ER beta transcriptional activity is abolished by ICI 182,780, but not by OHT