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ADCYAP1 — CASP3

Text-mined interactions from Literome

Vaudry et al., Proc Natl Acad Sci U S A 2000 : In the present study, we have investigated the possible effect of PACAP on caspase activity in cultured cerebellar granule cells from 8-day-old rat ... Time-course studies revealed that PACAP causes a prolonged inhibition of caspase-3 activity without affecting caspase-1 ... Cotreatment of cultured neurons with the protein kinase A inhibitor H89 and the protein kinase C inhibitor chelerythrine abrogated the effect of PACAP on caspase-3 activity
Vaudry et al., J Neurosci Res 2003 : C2-ceramide induced a time dependent activation of caspase-3, enhanced the amount of cleaved caspase-3 and stimulated the DNA fragmentation process, while PACAP strongly inhibited the C2-ceramide induced activation of caspase-3 , reduced the expression of cleaved caspase-3 and blocked DNA fragmentation
Mei et al., Eur J Neurosci 2004 : Our data also show that PACAP and TEA induce long-term depolarization of the resting membrane potential, promote cell survival and inhibit caspase-3 activity, suggesting that PACAP evoked inhibition of I ( K ) contributes to the anti-apoptotic effect of the peptide on cerebellar granule cells
Falluel-Morel et al., J Neurochem 2004 : However, the mechanisms leading to the opposite regulation of caspase-3 by C2-ceramide and PACAP are currently unknown
Rácz et al., Regul Pept 2006 (Retinal Diseases) : Furthermore, PACAP treatment alone decreased cytosolic AIF and cytochrome c levels, while PACAP6-38 increased cytochrome c release, caspase-3 and JNK activity and decreased phospho-Bad activity
Li et al., Peptides 2010 (Acute Kidney Injury) : PACAP38 prevented the decrease in the apurinic/apyrimidinic endonuclease-1 by suppressing p53 activation and blocked the cleavage of caspase-7 and PARP-1 in cisplatin exposed cells
Masmoudi-Kouki et al., J Neurochem 2011 : In addition, PACAP prevented the decrease of mitochondrial activity and caspase 3 activation induced by H ( 2 ) O ( 2 )