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PRKAR2B — TNFSF11
Text-mined interactions from Literome
Fujita et al., Prostaglandins Leukot Essent Fatty Acids 2003
:
Investigation of intracellular signaling verified that low-density PGE ( 2 ) suppressed PKA activity in undifferentiated cells, suggesting that PGE ( 2 ) acts on the osteoclastic cell lineage to facilitate cell differentiation by suppressing
PKA in the
presence of
RANKL
Nukaga et al., J Periodontol 2004
:
The PGE2 stimulated
RANKL expression was
mediated by EP2/4 and cAMP dependent
PKA , while PKC was possibly involved in the PGE2 action
Takami et al., FEBS Lett 2005
:
Induction of TRANCE expression by IBMX was partially suppressed by the inhibitors of protein kinase A (PKA), ERK, and p38 MAPK, suggesting that activation of ERK and p38 MAPK, as well as
PKA , is
involved in
TRANCE expression by IBMX
Bai et al., J Biol Chem 2005
(Bone Resorption) :
In human MG63 cells, however, we found that ROS promoted heat shock factor 2 (HSF2) binding to heat shock element in human RANKL promoter region and that HSF2, but not
PKA , was
required for ROS up-regulation of
RANKL as revealed by KT5720 and HSF2 RNA interference transfection
Kim et al., Mol Endocrinol 2007
:
This study demonstrates that the
activation of
RankL gene expression by
PKA- and gp130-inducers is mediated via common regulatory domains that also served to facilitate the activity of 1,25- ( OH ) 2D3